4-Hydroxy-5-methoxydimethyltryptamine: Difference between revisions
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Theoretically, this method would 4-hydroxylate and 4-phosphoryloxylate any tryptamine added to the substrate, opening the possibility of synthesizing as yet undiscovered tryptamines. |
Theoretically, this method would 4-hydroxylate and 4-phosphoryloxylate any tryptamine added to the substrate, opening the possibility of synthesizing as yet undiscovered tryptamines. |
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Manufacture, transportation, possession, and distribution of 4-HO-5-MeO-DMT in the United States |
Manufacture, transportation, possession, and distribution of 4-HO-5-MeO-DMT in the United States may be illegal under the [[Federal Analogue Act]] due to its structural relation to psilocin, which is listed as a [[List of Schedule I drugs (US)|Schedule I narcotic]] under the [[Controlled Substances Act]] of 1970. |
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Due to the resemblance to the neurotoxin 4,5-dihydroxytryptamine, there is some concern that this compound may share that neurotoxicity, though this has not been investigated. |
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== References == |
== References == |
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Revision as of 19:37, 8 March 2018
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| CAS Number | |
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| Chemical and physical data | |
| Formula | C13H18N2O2 |
| Molar mass | 234.30 g/mol g·mol−1 |
| 3D model (JSmol) | |
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4-Hydroxy-5-methoxydimethyltryptamine, also known as 4-HO-5-MeO-DMT or psilomethoxin, is a novel psychedelic drug. It is the 4-hydroxy counterpart of 5-MeO-DMT, or the 5-methoxy counterpart of psilocin.
It is a psychedelic tryptamine but very little is known about it. The only report of it in the chemical literature was a paper published by Marc Julia's group at the Pasteur Institute in 1965.[1]
Their paper cites a 10 step synthesis of 4-HO-5-MeO-DMT from ortho-vanillin. However, Alexander Shulgin has explained that it could be possible to cultivate 4-HO-5-MeO-DMT in psilocybin mushrooms by adding 5-MeO-DMT to the growing substrate of the fungus. Though this method has never been explored with 5-MeO-DMT, it has been used successfully for changing DET into 4-HO-DET and 4-PO-DET, both of which had never before been found in nature.[2]
In the case of DET the mushrooms yielded only 4-HO-DET or 4-PO-DET respectively, instead of psilocin (4-HO-DMT) and psilocybin (4-PO-DMT), suggesting that the presence of the extraneous N-dialkylated tryptamines competed for the enzymes in the fungus mycelium that would normally produce psilocin. This method thus not only produced new chemical compounds that had never previously been made synthetically, but also rendered the fungus itself completely legal in many countries because of its absence of psilocin or psilocybin, although in countries with stricter drug analogue laws such as the USA or Australia the novel tryptamines produced might also be considered illegal.
Theoretically, this method would 4-hydroxylate and 4-phosphoryloxylate any tryptamine added to the substrate, opening the possibility of synthesizing as yet undiscovered tryptamines.
Manufacture, transportation, possession, and distribution of 4-HO-5-MeO-DMT in the United States may be illegal under the Federal Analogue Act due to its structural relation to psilocin, which is listed as a Schedule I narcotic under the Controlled Substances Act of 1970.
Due to the resemblance to the neurotoxin 4,5-dihydroxytryptamine, there is some concern that this compound may share that neurotoxicity, though this has not been investigated.
References
- ^ Julia M, Manoury P, Voillaume MC (1965). "[No 209 - Recherches en série indolique. XIV (*) - Sur des méthoxy-5 hydroxy-4, méthoxy-5 hydroxy-6 et méthoxy-7 hydroxy-6 tryptamines]". Bull Chim Soc Fr (in French): 1417–23.
- ^ Gartz J (1989). "Biotransformation of tryptamine derivatives in mycelial cultures of Psilocybe". J. Basic Microbiol. 29 (6): 347–52. doi:10.1002/jobm.3620290608. PMID 2614674.