C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10gene.[5][6]
Function
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.[6]
CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28.[7] This receptor is normally expressed by melanocytes,[8] plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph nodemetastasis in mice after inoculation in the skin,[9] suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.[10]
Bonini JA; Martin SK; Dralyuk F; et al. (1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID9364936. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lehner B; Semple JI; Brown SE; et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID14667819. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Notohamiprodjo M; Segerer S; Huss R; et al. (2005). "CCR10 is expressed in cutaneous T-cell lymphoma". Int. J. Cancer. 115 (4): 641–7. doi:10.1002/ijc.20922. PMID15700309. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rodrigues-Lisoni FC; Mehet DK; Mehemet DK; et al. (2006). "In vitro and in vivo studies on CCR10 regulation by Annexin A1". FEBS Lett. 580 (5): 1431–8. doi:10.1016/j.febslet.2006.01.072. hdl:11449/21716. PMID16460738. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)