Anileridine

Anileridine
Clinical data
AHFS/Drugs.com	Monograph
Routes of; administration	Tablets, injection
ATC code	N01AH05 (WHO) ;
Legal status
Legal status	AU: S8 (Controlled drug); CA: Schedule I; DE: Anlage I (Authorized scientific use only); US: Schedule II;
Pharmacokinetic data
Protein binding	> 95%
Metabolism	Hepatic
Identifiers
	IUPAC name Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate;
CAS Number	144-14-9 ;
PubChem CID	8944;
IUPHAR/BPS	7115;
DrugBank	DB00913 ;
ChemSpider	8600 ;
UNII	71Q1A3O279;
KEGG	D02941 ;
ChEBI	CHEBI:61203 ;
ChEMBL	ChEMBL1201347 ;
CompTox Dashboard (EPA)	DTXSID8022610 ;
Chemical and physical data
Formula	C22H28N2O2
Molar mass	352.478 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	83 °C (181 °F)
	SMILES O=C(OCC)C3(c1ccccc1)CCN(CCc2ccc(N)cc2)CC3;
	InChI InChI=1S/C22H28N2O2/c1-2-26-21(25)22(19-6-4-3-5-7-19)13-16-24(17-14-22)15-12-18-8-10-20(23)11-9-18/h3-11H,2,12-17,23H2,1H3 ; Key:LKYQLAWMNBFNJT-UHFFFAOYSA-N ;
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Anileridine (trade name: Leritine) is a synthetic analgesic drug and is a member of the piperidine class of analgesic agents developed by Merck & Co. in the 1950s.^[1] It differs from pethidine (meperidine) in that the N-methyl group of meperidine is replaced by an N-aminophenethyl group, which increases its analgesic activity.

Anileridine is no longer manufactured in the US or Canada.^[2] Anileridine is in Schedule II of the Controlled Substances Act 1970 of the United States as ACSCN 9020 with a zero aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.83 for the dihydrochloride and 0.73 for the phosphate ^[3] It is also under international control per UN treaties.

Administration

As tablets or injection.^[4]

Pharmacokinetics

Anileridine usually takes effect within 15 minutes of either oral or intravenous administration, and lasts 2–3 hours.^[5] It is mostly metabolized by the liver.

References

^ U.S. patent 2,897,204
^ "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Archived from the original on 19 September 2008. Retrieved 28 July 2008.
^ http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm
^ "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010.
^ "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.

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[1] U.S. patent 2,897,204

[2] "Discontinued Prescription Drug Products". Canadian Pharmacists' Association. Archived from the original on 19 September 2008. Retrieved 28 July 2008.

[3] ttp://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm

[4] "Pharmaceutical Information - LERITINE". RxMed. Retrieved 16 June 2010.

[5] "Anileridine Consumer Information". MedicineNet. Retrieved 28 July 2008.

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