Tandamine

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Tandamine
Clinical data
ATC code
  • none
Identifiers
  • 2-(9-ethyl-1-methyl-3,4-dihydrothiopyrano[3,4-b]indol-1-yl)-N,N-dimethylethanamine
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC18H26N2S
Molar mass302.48 g·mol−1
3D model (JSmol)
  • CCn3c1ccccc1c2CCSC(C)(CCN(C)C)c23
  • InChI=1S/C18H26N2S/c1-5-20-16-9-7-6-8-14(16)15-10-13-21-18(2,17(15)20)11-12-19(3)4/h6-9H,5,10-13H2,1-4H3
  • Key:BRPOADLGOFPKKJ-UHFFFAOYSA-N
  (verify)

Tandamine is a selective norepinephrine reuptake inhibitor with a tricyclic structure.[1][2][3] It was developed in the 1970s as an antidepressant but was never commercialized.[1][2][3] Tandamine is analogous to pirandamine, which, instead, acts as a selective serotonin reuptake inhibitor (SSRI).[4][5]

See also

References

  1. ^ a b Lippmann W, Pugsley TA (May 1976). "The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities". Biochemical Pharmacology. 25 (10): 1179–86. doi:10.1016/0006-2952(76)90366-X. PMID 1084746.
  2. ^ a b Ehsanullah RS, Ghose K, Kirby MJ, Turner P, Witts D (March 1977). "Clinical pharmacological studies of tandamine, a potential antidepressive drug". Psychopharmacology. 52 (1): 73–7. doi:10.1007/BF00426603. PMID 403562.
  3. ^ a b Pugsley TA, Lippmann W (September 1979). "Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities". Naunyn-Schmiedeberg's Archives of Pharmacology. 308 (3): 239–47. doi:10.1007/BF00501388. PMID 503251.
  4. ^ Pugsley T, Lippmann W (May 1976). "Effects of tandamine and pirandamine, new potential antidepressants, on the brain uptake of norepinephrine and 5-hydroxytryptamine and related activities". Psychopharmacology. 47 (1): 33–41. doi:10.1007/BF00428698. PMID 1085452.
  5. ^ Lippmann W, Seethaler K (April 1977). "Effects of tandamine and pirandamine, selective blockers of biogenic amine uptake mechanisms, on gastric acid secretion and ulcer formation in the rat". Life Sciences. 20 (8): 1393–400. doi:10.1016/0024-3205(77)90367-8. PMID 853871.


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