CCR10

CCR10
Identifiers
Aliases	CCR10, GPR2, C-C motif chemokine receptor 10
External IDs	OMIM: 600240; MGI: 1096320; HomoloGene: 7271; GeneCards: CCR10; OMA:CCR10 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,683,917 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,066,269 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Pituitary Gland; ; anterior pituitary; ; right hemisphere of cerebellum; ; body of uterus; ; left uterine tube; ; apex of heart; ; canal of the cervix; ; left ovary; ; right ovary;
	Top expressed in
	embryo; ; embryo; ; esophagus; ; duodenum; ; granulocyte; ; neural layer of retina; ; lip; ; jejunum; ; muscle tissue; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	C-C chemokine receptor activity; G protein-coupled receptor activity; chemokine receptor activity; signal transducer activity; protein binding; chemokine binding; C-C chemokine binding;
Cellular component	cell surface; integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; endoplasmic reticulum; external side of plasma membrane;
Biological process	positive regulation of cytosolic calcium ion concentration; chemotaxis; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; immune response; signal transduction; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	2826
	12777
	ENSG00000184451
	ENSMUSG00000044052
	P46092
	Q9JL21
	NM_016602
	NM_007721
	NP_057686
	NP_031747
	Wikidata
View/Edit Human	View/Edit Mouse

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.^[5]^[6]

Function

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.^[6]

CCR10 is a chemokine receptor. Its ligands are CCL27 and CCL28.^[7] This receptor is normally expressed by melanocytes,^[8] plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin,^[9] suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184451 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044052 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.
^ ^a ^b "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10".
^ Balkwill F (July 2004). "Cancer and the chemokine network". Nat. Rev. Cancer. 4 (7): 540–50. doi:10.1038/nrc1388. PMID 15229479.
^ Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.
^ Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST (November 2003). "Immune evasion by murine melanoma mediated through CC chemokine receptor-10". J. Exp. Med. 198 (9): 1337–47. doi:10.1084/jem.20030593. PMC 2194242. PMID 14581607.
^ Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Bonini JA; Martin SK; Dralyuk F; et al. (1997). "Cloning, expression, and chromosomal mapping of a novel human CC-chemokine receptor (CCR10) that displays high-affinity binding for MCP-1 and MCP-3". DNA Cell Biol. 16 (10): 1249–56. doi:10.1089/dna.1997.16.1249. PMID 9364936. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gosling J; Dairaghi DJ; Wang Y; et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Jarmin DI; Rits M; Bota D; et al. (2000). "Cutting edge: identification of the orphan receptor G-protein-coupled receptor 2 as CCR10, a specific receptor for the chemokine ESkine". J. Immunol. 164 (7): 3460–4. doi:10.4049/jimmunol.164.7.3460. PMID 10725696. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Homey B; Wang W; Soto H; et al. (2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Wang W; Soto H; Oldham ER; et al. (2000). "Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)". J. Biol. Chem. 275 (29): 22313–23. doi:10.1074/jbc.M001461200. PMID 10781587. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Pan J; Kunkel EJ; Gosslar U; et al. (2000). "A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues". J. Immunol. 165 (6): 2943–9. doi:10.4049/jimmunol.165.6.2943. PMID 10975800. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Patel L, Charlton SJ, Chambers JK, Macphee CH (2001). "Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations". Cytokine. 14 (1): 27–36. doi:10.1006/cyto.2000.0851. PMID 11298490.
Homey B; Alenius H; Müller A; et al. (2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lehner B; Semple JI; Brown SE; et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Notohamiprodjo M; Segerer S; Huss R; et al. (2005). "CCR10 is expressed in cutaneous T-cell lymphoma". Int. J. Cancer. 115 (4): 641–7. doi:10.1002/ijc.20922. PMID 15700309. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rodrigues-Lisoni FC; Mehet DK; Mehemet DK; et al. (2006). "In vitro and in vivo studies on CCR10 regulation by Annexin A1". FEBS Lett. 580 (5): 1431–8. doi:10.1016/j.febslet.2006.01.072. PMID 16460738. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Fujita Y; Abe R; Sasaki M; et al. (2006). "Presence of circulating CCR10+ T cells and elevated serum CTACK/CCL27 in the early stage of mycosis fungoides". Clin. Cancer Res. 12 (9): 2670–5. doi:10.1158/1078-0432.CCR-05-1513. PMID 16675558. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Eksteen B; Miles A; Curbishley SM; et al. (2006). "Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10". J. Immunol. 177 (1): 593–603. doi:10.4049/jimmunol.177.1.593. PMID 16785557. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Harasawa H; Yamada Y; Hieshima K; et al. (2007). "Survey of chemokine receptor expression reveals frequent co-expression of skin-homing CCR4 and CCR10 in adult T-cell leukemia/lymphoma". Leuk. Lymphoma. 47 (10): 2163–73. doi:10.1080/10428190600775599. PMID 17071491. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

External links

Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.
"Chemokine Receptors: CCR10". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184451 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044052 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7851889-5] Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (Mar 1995). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID 7851889.

[entrez-6] "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10".

[pmid15229479-7] Balkwill F (July 2004). "Cancer and the chemokine network". Nat. Rev. Cancer. 4 (7): 540–50. doi:10.1038/nrc1388. PMID 15229479.

[pmid10725697-8] Homey B, Wang W, Soto H, Buchanan ME, Wiesenborn A, Catron D, Müller A, McClanahan TK, Dieu-Nosjean MC, Orozco R, Ruzicka T, Lehmann P, Oldham E, Zlotnik A (April 2000). "Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC)". J. Immunol. 164 (7): 3465–70. doi:10.4049/jimmunol.164.7.3465. PMID 10725697.

[pmid14581607-9] Murakami T, Cardones AR, Finkelstein SE, Restifo NP, Klaunberg BA, Nestle FO, Castillo SS, Dennis PA, Hwang ST (November 2003). "Immune evasion by murine melanoma mediated through CC chemokine receptor-10". J. Exp. Med. 198 (9): 1337–47. doi:10.1084/jem.20030593. PMC 2194242. PMID 14581607.

[pmid11821900-10] Homey B, Alenius H, Müller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, Lehto M, Wolff H, Yen D, Marxhausen H, To W, Sedgwick J, Ruzicka T, Lehmann P, Zlotnik A (February 2002). "CCL27-CCR10 interactions regulate T cell-mediated skin inflammation". Nat. Med. 8 (2): 157–65. doi:10.1038/nm0202-157. PMID 11821900.

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Function

References

Further reading

External links