Natural resistance-associated macrophage protein 1

SLC11A1
Identifiers
Aliases	SLC11A1, LSH, NRAMP, NRAMP1, solute carrier family 11 member 1
External IDs	OMIM: 600266; MGI: 1345275; HomoloGene: 73884; GeneCards: SLC11A1; OMA:SLC11A1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	218,396,894 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	74,425,221 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; granulocyte; ; monocyte; ; blood; ; spleen; ; buccal mucosa cell; ; left uterine tube; ; left adrenal cortex; ; bone marrow cells;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; spleen; ; internal carotid artery; ; mesenteric lymph nodes; ; tibiofemoral joint; ; morula; ; ciliary body; ; blood; ; carotid body;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	manganese ion transmembrane transporter activity; protein homodimerization activity; transition metal ion transmembrane transporter activity; metal ion:proton antiporter activity; metal ion transmembrane transporter activity; cadmium ion transmembrane transporter activity; iron ion transmembrane transporter activity;
Cellular component	integral component of membrane; late endosome; phagocytic vesicle membrane; membrane; late endosome membrane; integral component of plasma membrane; lysosome; endosome membrane; plasma membrane; tertiary granule membrane; ficolin-1-rich granule membrane;
Biological process	manganese ion transmembrane transport; interleukin-3 production; positive regulation of phagocytosis; response to bacterium; response to interferon-gamma; positive regulation of cytokine production; iron ion homeostasis; positive regulation of interferon-gamma production; wound healing; ion transport; cellular cadmium ion homeostasis; cell redox homeostasis; T cell proliferation involved in immune response; vacuolar acidification; respiratory burst; multicellular organismal iron ion homeostasis; mRNA stabilization; response to lipopolysaccharide; antigen processing and presentation of peptide antigen; positive regulation of dendritic cell antigen processing and presentation; positive regulation of gene expression; iron ion transport; defense response to bacterium; positive regulation of T-helper 1 type immune response; MHC class II biosynthetic process; defense response to Gram-negative bacterium; cadmium ion transmembrane transport; phagocytosis; manganese ion transport; nitrite transport; macrophage activation; inflammatory response; T cell cytokine production; interleukin-2 production; negative regulation of cytokine production; activation of protein kinase activity; positive regulation of transcription by RNA polymerase II; cellular iron ion homeostasis; defense response to protozoan; antimicrobial humoral response; neutrophil degranulation; metal ion transport; iron ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	6556
	18173
	ENSG00000018280
	ENSMUSG00000026177
	P49279
	P41251
	NM_000578; NM_001032220
	NM_013612
	NP_000569
	NP_038640
	Wikidata
View/Edit Human	View/Edit Mouse

Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000018280 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026177 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cellier M; Govoni G; Vidal S; Kwan T; Groulx N; Liu J; Sanchez F; Skamene E; Schurr E; Gros P (Dec 1994). "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression". J Exp Med. 180 (5): 1741–52. doi:10.1084/jem.180.5.1741. PMC 2191750. PMID 7964458.
^ Kishi F (Dec 1994). "Isolation and characterization of human Nramp cDNA". Biochem. Biophys. Res. Commun. 204 (3): 1074–80. doi:10.1006/bbrc.1994.2572. PMID 7980580.
^ "Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1".

Natural resistance-associated macrophage protein 1

See also

References

Further reading