|(what is this?)|
Interferon alfa-2b is an antiviral or antineoplastic drug. It is a recombinant form of the protein Interferon alpha-2 that was originally sequenced and produced recombinantly in E. coli in the laboratory of Charles Weissmann at the University of Zurich, in 1980. It was developed at Biogen, and ultimately marketed by Schering-Plough under the trade name Intron-A. It was also produced in 1986 in recombinant human form, in the Center for Genetic Engineering and Biotechnology of Havana, Cuba, under the name Heberon® Alfa R.
It has been used for a wide range of indications, including viral infections and cancers. This drug is approved around the world for the treatment of chronic hepatitis C, chronic hepatitis B, hairy cell leukemia, Behçet's disease, chronic myelogenous leukemia, multiple myeloma, follicular lymphoma, carcinoid tumor, mastocytosis and malignant melanoma.
So far, two non-peer reviewed research articles have been published. One study at the University of Texas Medical Branch, Galveston, showed evidence of a direct anti-viral effect of Interferon alpha against novel Coronavirus in vitro. The study demonstrated around 10,000 fold reduction in the quantity of virus that was pre-treated with Interferon alpha 48 hours earlier. A second study by universities in China, Australia and Canada analysed 77 moderate COVID-19 subjects in Wuhan and observed that those who received Interferon alpha-2b showed a significant reduction in the duration of virus shedding period and even in levels of the inflammatory cytokine, IL-6.  
|Interferon alfa-2b products|
|Reaferon EC||GNC Vector|
|Altevir||Bioprocess subsidiary||liquid, free of HSA|
|Kipferon||Alfarm||combination with IgM, IgA, IgG|
|Opthalamoferon||Firn-M||with dimedrol||eye infections|
|Heberon Alfa R||BioCubaFarma, Cuban-Chinese joint venture ChangHeber||severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)|
- Nagata, Shigekazu; Taira, Hideharu; Hall, Alan; Johnsrud, Lorraine; Streuli, Michel; Ecsödi, Josef; Boll, Werner; Cantell, Kari; Weissmann, Charles (1980). "Synthesis in E. coli of a polypeptide with human leukocyte interferon activity". Nature. 284 (5754): 316–320. Bibcode:1980Natur.284..316N. doi:10.1038/284316a0. ISSN 1476-4687. PMID 6987533.
- Weissmann, Charles (2001). "Recombinant interferon - the 20th anniversary". In Buckel, Peter (ed.). Recombinant Protein Drugs. Milestones in Drug Therapy. Basel: Birkhäuser. pp. 3–41. doi:10.1007/978-3-0348-8346-7_1. ISBN 978-3-0348-8346-7.
- Mantei, Ned; Schwarzstein, Marco; Streuli, Michel; Panem, Sandra; Nagata, Shigekazu; Weissmann, Charles (1980-06-01). "The nucleotide sequence of a cloned human leukocyte Interferon cDNA". Gene. 10 (1): 1–10. doi:10.1016/0378-1119(80)90137-7. ISSN 0378-1119. PMID 6157600.
- Nodarse-Cuní, Hugo; López-Saura, Pedro A. (2017). "Cuban interferon alpha-2b. Thirty years as an effective and safe drug". Biotecnología Aplicada. 34 (1): 1211–1217. ISSN 1027-2852.
- EDT, Tom O'Connor On 3/24/20 at 5:34 PM (March 24, 2020). "Cuba uses "wonder drug" to fight coronavirus around the world despite U.S. sanctions". Newsweek.
- Dmitrij I. Bairamashvili1 and Mikhail L. Rabinovich2* (2007). "Russia through the prism of the world biopharmaceutical market" (PDF). Biotechnol. J. 2. Archived from the original (PDF) on 2012-02-24. Retrieved 2009-06-14.
|Wikimedia Commons has media related to Interferon alfa-2b.|
- Intron-A Summary of Product Characteristics
- Nagata S, Taira H, Hall A, et al. (Mar 1980). "Synthesis in E. coli of a polypeptide with human leukocyte interferon activity". Nature. 284 (5754): 316–20. Bibcode:1980Natur.284..316N. doi:10.1038/284316a0. PMID 6987533.
|This antiinfective drug article is a stub. You can help Wikipedia by expanding it.|
|This antineoplastic or immunomodulatory drug article is a stub. You can help Wikipedia by expanding it.|