GABA transporter 1

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Solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Identifiers
Symbols SLC6A1 ; GABATHG; GABATR; GAT1
External IDs OMIM137165 MGI95627 HomoloGene2290 ChEMBL: 1903 GeneCards: SLC6A1 Gene
RNA expression pattern
PBB GE SLC6A1 205152 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6529 232333
Ensembl ENSG00000157103 ENSMUSG00000030310
UniProt P30531 P31648
RefSeq (mRNA) NM_003042 NM_178703
RefSeq (protein) NP_003033 NP_848818
Location (UCSC) Chr 3:
11.03 – 11.08 Mb
Chr 6:
114.28 – 114.32 Mb
PubMed search [1] [2]

GABA transporter 1 (GAT-1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.[1][2]

Function[edit]

GAT-1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft.[3]

Interactions[edit]

SLC6A1 has been shown to interact with STX1A.[4][5][6]

See also[edit]

References[edit]

  1. ^ Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). "Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25". Genomics 29 (1): 302–4. doi:10.1006/geno.1995.1253. PMID 8530094. 
  2. ^ "Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1". 
  3. ^ Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). "Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity". Pharmacogenet. Genomics 19 (1): 53–65. doi:10.1097/FPC.0b013e328318b21a. PMID 19077666. 
  4. ^ Beckman, M L; Bernstein E M; Quick M W (August 1998). "Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A". J. Neurosci. (UNITED STATES) 18 (16): 6103–12. ISSN 0270-6474. PMID 9698305. 
  5. ^ Quick, Michael W (April 2002). "Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (8): 5686–91. doi:10.1073/pnas.082712899. ISSN 0027-8424. PMC 122832. PMID 11960023. 
  6. ^ Deken, S L; Beckman M L; Boos L; Quick M W (October 2000). "Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A". Nat. Neurosci. (UNITED STATES) 3 (10): 998–1003. doi:10.1038/79939. ISSN 1097-6256. PMID 11017172. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.