Alnespirone

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Alnespirone
Alnespirone.svg
Systematic (IUPAC) name
(+)-4-dihydro-2H-chromen-3-yl]-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione
Clinical data
Legal status ?
Identifiers
CAS number 143413-68-7 YesY
ATC code None
PubChem CID 178132
ChemSpider 8002134 YesY
UNII 34E28BM822 YesY
ChEMBL CHEMBL2104091
Chemical data
Formula C26H38N2O4 
Mol. mass 442.589 g/mol
 YesY (what is this?)  (verify)

Alnespirone (S-20,499) is a selective 5-HT1A receptor full agonist of the azapirone chemical class.[1][2][3] It has antidepressant and anxiolytic effects.[1]

See also[edit]

References[edit]

  1. ^ a b Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J. (1992). "Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice.". Neuroreport. 3 (1): 84–86. doi:10.1097/00001756-199201000-00022. PMID 1351756. 
  2. ^ Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J. (1992). "5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists.". Psychopharmacology (Berl). 108 (1-2): 47–50. doi:10.1007/BF02245284. PMID 1357709. 
  3. ^ Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G. (2003). "In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity.". Eur J Pharmacol. 459 (1): 17–26. doi:10.1016/S0014-2999(02)02814-5. PMID 12505530.