From Wikipedia, the free encyclopedia
Desmethylflunitrazepam (also known as norflunitrazepam , Ro05-4435 and fonazepam ) is a benzodiazepine that is a metabolite of flunitrazepam [ 1] [ 2] [ 3] and has been sold online as a designer drug .[ 4] [ 5] It has an IC50 value of 1.499 nM for the GABAA receptor.[ 6] [ 7]
See also
References
^ Busker, Ruud W.; van Henegouwen, Gerard M. J. Beijersbergen; Kwee, Brigitta M. C.; Winkens, Jos H. M. (May 1987). "Photobinding of flunitrazepam and its major photo-decomposition product N-desmethylflunitrazepam" . International Journal of Pharmaceutics . 36 (2–3): 113–120. doi :10.1016/0378-5173(87)90145-1 – via ScienceDirect.
^ Coller, Janet K; Somogyi, Andrew A; Bochner, Felix (20 November 1998). "Quantification of flunitrazepam's oxidative metabolites, 3-hydroxyflunitrazepam and desmethylflunitrazepam, in hepatic microsomal incubations by high-performance liquid chromatography" . Journal of Chromatography B . 719 (1–2): 87–92. doi :10.1016/S0378-4347(98)00383-1 . PMID 9869368 – via ScienceDirect.
^ Kilicarslan, Tansel; Haining, Robert L.; Rettie, Allan E.; Busto, Usanda; Tyndale, Rachel F.; Sellers, Edward M. (1 April 2001). "Flunitrazepam Metabolism by Cytochrome P450s 2C19 and 3A4" . Drug Metabolism and Disposition . 29 (4): 460–465. ISSN 1521-009X . PMID 11259331 – via dmd.aspetjournals.org.
^ Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; Huppertz, Laura M.; Auwärter, Volker (2016). "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines – an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam, and nitrazolam". Journal of Mass Spectrometry . 51 (11): 1080–1089. doi :10.1002/jms.3840 . ISSN 1096-9888 . PMID 27535017 .
^ Katselou, Maria; Papoutsis, Ioannis; Nikolaou, Panagiota; Spiliopoulou, Chara; Athanaselis, Sotiris (2016). "Metabolites replace the parent drug in the drug arena. The cases of fonazepam and nifoxipam" . Forensic Toxicology . 35 (1): 1–10. doi :10.1007/s11419-016-0338-5 . ISSN 1860-8973 . PMC 5214877 . PMID 28127407 .
^ Maddalena, Desmond J.; Johnston, Graham A. R. (February 1995). "Prediction of Receptor Properties and Binding Affinity of Ligands to Benzodiazepine/GABAA Receptors Using Artificial Neural Networks". Journal of Medicinal Chemistry . 38 (4): 715–724. doi :10.1021/jm00004a017 . PMID 7861419 .
^ So, Sung-Sau; Karplus, Martin (20 December 1996). "Genetic Neural Networks for Quantitative Structure−Activity Relationships: Improvements and Application of Benzodiazepine Affinity for Benzodiazepine/GABAA Receptors". Journal of Medicinal Chemistry . 39 (26): 5246–5256. doi :10.1021/jm960536o . PMID 8978853 .
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