LP-211

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LP-211
Identifiers
  • N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC30H34N4O
Molar mass466.616 g/mol g·mol−1
3D model (JSmol)
  • N#Cc3ccc(cc3)CNC(=O)CCCCCN(CC2)CCN2c1ccccc1-c4ccccc4
  (verify)

LP-211 is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor, with better brain penetration than older 5-HT7 agonists in the same series, and similar effects in animals.[1][2]

See also

References

  1. ^ Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R (August 2010). "LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor". Neuroscience Letters. 481 (1): 12–6. doi:10.1016/j.neulet.2010.06.036. PMC 2910240. PMID 20600619.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews. 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634.
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