1-(2-Diphenyl)piperazine

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1-(2-Diphenyl)piperazine
1-(2-diphenyl)piperazine structure.png
Identifiers
PubChem (CID) 2737389
ChemSpider 2019031 YesY
ChEMBL CHEMBL494675 YesY
Chemical and physical data
Formula C16H18N2
Molar mass 238.327 g/mol
3D model (Jmol) Interactive image
  (verify)

1-(2-Diphenyl)piperazine, also known as RA-7, is a drug which acts as a potent and selective agonist at the 5HT7 serotonin receptor. It was discovered as an active metabolite of the synthetic 5-HT7 agonists LP-12 and LP-211, and unexpectedly turned out to be a similarly potent agonist with selectivity approaching that of the parent molecules, despite its much simpler structure.[1]

See also[edit]

References[edit]

  1. ^ Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R (August 2010). "LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor". Neuroscience Letters. 481 (1): 12–6. doi:10.1016/j.neulet.2010.06.036. PMC 2910240Freely accessible. PMID 20600619.