Interleukin 20 receptor, alpha subunit: Difference between revisions
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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category) |
Immcarle189 (talk | contribs) Edited introduction to have more details. Ex. include other receptors it's a subunit of. Also added to location of receptor. |
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
{{Infobox_gene}} |
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'''Interleukin 20 [[Receptor (biochemistry)|receptor]], alpha subunit''', is a [[Protein subunit|subunit]] of the [[interleukin-20 receptor]], the [[Interleukin 26|interleukin-26]] receptor, and the [[Interleukin 24|interleukin-24]] receptor<ref name=":0">{{Cite journal |last=Wegenka |first=Ursula Maria |date=2010-10-01 |title=IL-20: Biological functions mediated through two types of receptor complexes |url=https://www.sciencedirect.com/science/article/pii/S1359610110000596 |journal=Cytokine & Growth Factor Reviews |series=IL-10 Family of Cytokines |language=en |volume=21 |issue=5 |pages=353–363 |doi=10.1016/j.cytogfr.2010.08.001 |issn=1359-6101}}</ref>. The interleukin 20 receptor, alpha subunit is also referred to as '''IL20R1'''<ref>{{Cite journal |last=Wirtz |first=Mary K. |last2=Keller |first2=Kate E. |date=2016 |title=The Role of the IL-20 Subfamily in Glaucoma |url=http://dx.doi.org/10.1155/2016/4083735 |journal=Mediators of Inflammation |volume=2016 |pages=1–8 |doi=10.1155/2016/4083735 |issn=0962-9351}}</ref> or '''''IL20RA.'''''<ref name=":1">{{Cite journal |last=Rutz |first=Sascha |last2=Wang |first2=Xiaoting |last3=Ouyang |first3=Wenjun |date=2014-12 |title=The IL-20 subfamily of cytokines — from host defence to tissue homeostasis |url=https://www.nature.com/articles/nri3766 |journal=Nature Reviews Immunology |language=en |volume=14 |issue=12 |pages=783–795 |doi=10.1038/nri3766 |issn=1474-1741}}</ref> The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the [[JAK-STAT pathway]].<ref name=":0" /> |
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'''Interleukin 20 receptor, alpha subunit''' is a subunit for the [[interleukin-20 receptor]]. '''''IL20RA''''' is its human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL20RA interleukin 20 receptor, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53832}}</ref> |
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IL<u>20RA is found in the skin, [[Lung|lungs]], [[Ovary|ovaries]], [[Testicle|testes]] and [[placenta]], with low [[gene expression]] in the [[Gastrointestinal tract|intestine]] and</u> [[liver]].<ref name=":1" /> IL20RB is found in many organ resident [[Effector cell|effector cells]] such as [[Keratinocyte|keratinocytes]] at the skin epidermis, [[Osteoclast|osteoclasts]], found in bones, and [[Epithelium|epithelial cells]] of the intestine and [[trachea]]. IL20RA is also found in some [[Immune system|immune]] cells.<ref name=":2">{{Cite journal |last=Kragstrup |first=Tue W. |last2=Andersen |first2=Thomas |last3=Heftdal |first3=Line D. |last4=Hvid |first4=Malene |last5=Gerwien |first5=Jens |last6=Sivakumar |first6=Pallavur |last7=Taylor |first7=Peter C. |last8=Senolt |first8=Ladislav |last9=Deleuran |first9=Bent |date=2018-09-25 |title=The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis |url=http://dx.doi.org/10.3389/fimmu.2018.02226 |journal=Frontiers in Immunology |volume=9 |doi=10.3389/fimmu.2018.02226 |issn=1664-3224}}</ref> |
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The protein encoded by this gene is a receptor for [[interleukin 20]] (IL20), a cytokine that may be involved in epidermal function. The receptor of IL20 is a [[heterodimeric]] receptor complex consisting of this protein and [[interleukin 20 receptor beta]] (IL20RB). This gene and ''IL20RB'' are highly expressed in skin. The expression of both genes is found to be upregulated in [[psoriasis]].<ref name="entrez" /> |
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==References== |
==References== |
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Revision as of 17:04, 10 March 2023
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| Aliases | IL20RA, CRF2-8, IL-20R-alpha, IL-20R1, IL-20RA, Interleukin 20 receptor, alpha subunit, interleukin 20 receptor subunit alpha | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605620; MGI: 3605069; HomoloGene: 8685; GeneCards: IL20RA; OMA:IL20RA - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Interleukin 20 receptor, alpha subunit, is a subunit of the interleukin-20 receptor, the interleukin-26 receptor, and the interleukin-24 receptor[5]. The interleukin 20 receptor, alpha subunit is also referred to as IL20R1[6] or IL20RA.[7] The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway.[5]
IL20RA is found in the skin, lungs, ovaries, testes and placenta, with low gene expression in the intestine and liver.[7] IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RA is also found in some immune cells.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000016402 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020007 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Wegenka, Ursula Maria (2010-10-01). "IL-20: Biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. IL-10 Family of Cytokines. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. ISSN 1359-6101.
- ^ Wirtz, Mary K.; Keller, Kate E. (2016). "The Role of the IL-20 Subfamily in Glaucoma". Mediators of Inflammation. 2016: 1–8. doi:10.1155/2016/4083735. ISSN 0962-9351.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ a b Rutz, Sascha; Wang, Xiaoting; Ouyang, Wenjun (2014-12). "The IL-20 subfamily of cytokines — from host defence to tissue homeostasis". Nature Reviews Immunology. 14 (12): 783–795. doi:10.1038/nri3766. ISSN 1474-1741.
{{cite journal}}: Check date values in:|date=(help) - ^ Kragstrup, Tue W.; Andersen, Thomas; Heftdal, Line D.; Hvid, Malene; Gerwien, Jens; Sivakumar, Pallavur; Taylor, Peter C.; Senolt, Ladislav; Deleuran, Bent (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9. doi:10.3389/fimmu.2018.02226. ISSN 1664-3224.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Xie MH, Aggarwal S, Ho WH, et al. (2000). "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R". J. Biol. Chem. 275 (40): 31335–31339. doi:10.1074/jbc.M005304200. PMID 10875937.
- Blumberg H, Conklin D, Xu WF, et al. (2001). "Interleukin 20: discovery, receptor identification, and role in epidermal function". Cell. 104 (1): 9–19. doi:10.1016/S0092-8674(01)00187-8. PMID 11163236. S2CID 7460710.
- Dumoutier L, Leemans C, Lejeune D, et al. (2001). "Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types". J. Immunol. 167 (7): 3545–9. doi:10.4049/jimmunol.167.7.3545. PMID 11564763.
- Wang M, Tan Z, Zhang R, et al. (2002). "Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2". J. Biol. Chem. 277 (9): 7341–7347. doi:10.1074/jbc.M106043200. PMID 11706020.
- Parrish-Novak J, Xu W, Brender T, et al. (2003). "Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions". J. Biol. Chem. 277 (49): 47517–47523. doi:10.1074/jbc.M205114200. PMID 12351624.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. doi:10.1038/nature02055. PMID 14574404.
- Pletnev S, Magracheva E, Kozlov S, et al. (2003). "Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20". Biochemistry. 42 (43): 12617–12624. doi:10.1021/bi0354583. PMID 14580208.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Sheikh F, Baurin VV, Lewis-Antes A, et al. (2004). "Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2". J. Immunol. 172 (4): 2006–10. doi:10.4049/jimmunol.172.4.2006. PMID 14764663.
- Hör S, Pirzer H, Dumoutier L, et al. (2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains". J. Biol. Chem. 279 (32): 33343–33351. doi:10.1074/jbc.M405000200. PMID 15178681.
- Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–2824. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
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