Concentrative nucleoside transporter 2: Difference between revisions

SLC28A2
Identifiers
Aliases	SLC28A2, CNT2, HCNT2, HsT17153, SPNT1, Concentrative nucleoside transporter 2, solute carrier family 28 member 2
External IDs	OMIM: 606208; MGI: 1913105; HomoloGene: 20891; GeneCards: SLC28A2; OMA:SLC28A2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	45,277,846 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	122,461,137 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of ileum; ; duodenum; ; rectum; ; buccal mucosa cell; ; gallbladder; ; mucosa of sigmoid colon; ; testicle; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa;
	Top expressed in
	jejunum; ; duodenum; ; ileum; ; granulocyte; ; spleen; ; thymus; ; quadriceps femoris muscle; ; colon; ; muscle tissue; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	purine nucleoside transmembrane transporter activity; nucleoside transmembrane transporter activity; nucleoside:sodium symporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	purine nucleoside transmembrane transport; nucleoside transmembrane transport; nucleobase-containing compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9153
	269346
	ENSG00000137860
	ENSMUSG00000027219
	O43868
	O88627
	NM_004212
	NM_172980; NM_001356532
	NP_004203
	NP_766568; NP_001343461; NP_001366388; NP_001366389
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 08:13, 22 December 2023

Concentrative nucleoside transporter 2 (CNT2) is a protein that in humans is encoded by the SLC28A2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137860 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027219 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM (Feb 1998). "Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization". Am J Physiol. 273 (6 Pt 2): F1058-65. doi:10.1152/ajprenal.1997.273.6.F1058. PMID 9435697.
^ "Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Ritzel MW, Yao SY, Ng AM, et al. (1999). "Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine". Mol. Membr. Biol. 15 (4): 203–11. doi:10.3109/09687689709044322. PMID 10087507.
Loewen SK, Ng AM, Yao SY, et al. (1999). "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2". J. Biol. Chem. 274 (35): 24475–84. doi:10.1074/jbc.274.35.24475. PMID 10455109.
Pennycooke M, Chaudary N, Shuralyova I, et al. (2001). "Differential expression of human nucleoside transporters in normal and tumor tissue". Biochem. Biophys. Res. Commun. 280 (3): 951–9. doi:10.1006/bbrc.2000.4205. PMID 11162617.
Li JY, Boado RJ, Pardridge WM (2001). "Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood–brain barrier". J. Pharmacol. Exp. Ther. 299 (2): 735–40. PMID 11602688.
Gerstin KM, Dresser MJ, Giacomini KM (2002). "Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT". Am. J. Physiol. Renal Physiol. 283 (2): F344–9. doi:10.1152/ajprenal.00274.2001. PMID 12110519. S2CID 21332585.
Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia". Blood. 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shin HC, Landowski CP, Sun D, et al. (2003). "Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum". Biochem. Biophys. Res. Commun. 307 (3): 696–703. doi:10.1016/S0006-291X(03)01259-2. PMID 12893280.
Lang TT, Young JD, Cass CE (2004). "Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line". Mol. Pharmacol. 65 (4): 925–33. doi:10.1124/mol.65.4.925. PMID 15044622. S2CID 5665725.
Damaraju VL, Visser F, Zhang J, et al. (2005). "Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside". Mol. Pharmacol. 67 (1): 273–9. doi:10.1124/mol.104.004408. PMID 15486050. S2CID 3017992.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Owen RP, Gray JH, Taylor TR, et al. (2005). "Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2". Pharmacogenet. Genomics. 15 (2): 83–90. doi:10.1097/01213011-200502000-00004. PMID 15861032. S2CID 12817964.
Owen RP, Badagnani I, Giacomini KM (2006). "Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2". J. Biol. Chem. 281 (36): 26675–82. doi:10.1074/jbc.M513421200. PMID 16840788.
Fernández-Veledo S, Jover R, Casado FJ, et al. (2007). "Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells". Biochem. Biophys. Res. Commun. 353 (2): 381–8. doi:10.1016/j.bbrc.2006.12.021. PMID 17187757.
Smith KM, Slugoski MD, Cass CE, et al. (2007). "Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3". Mol. Membr. Biol. 24 (1): 53–64. doi:10.1080/09687860600942534. PMID 17453413. S2CID 20779608.
Hirsh AJ, Stonebraker JR, van Heusden CA, et al. (2007). "Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases". Biochemistry. 46 (36): 10373–83. doi:10.1021/bi7009647. PMID 17696452.
Li L, Tan CM, Koo SH, et al. (2007). "Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians". Pharmacogenet. Genomics. 17 (9): 783–6. doi:10.1097/FPC.0b013e3281c10e41. PMID 17700367.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137860 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027219 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9435697-5] Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM (Feb 1998). "Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization". Am J Physiol. 273 (6 Pt 2): F1058-65. doi:10.1152/ajprenal.1997.273.6.F1058. PMID 9435697.

[entrez-6] "Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2".

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
+{{Short description|Protein found in humans}}
 {{Infobox_gene}}
-'''Concentrative nucleoside transporter 2''' ('''CNT2''') is a [[protein]] that in humans is encoded by the ''SLC28A2'' [[gene]].<ref name="pmid9435697">{{cite journal | vauthors = Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM | title = Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization | journal = Am J Physiol | volume = 273 | issue = 6 Pt 2 | pages = F1058-65 |date=Feb 1998 | pmid = 9435697 | pmc =  | doi =  10.1152/ajprenal.1997.273.6.F1058}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9153| accessdate = }}</ref>
+'''Concentrative nucleoside transporter 2''' ('''CNT2''') is a [[protein]] that in humans is encoded by the ''SLC28A2'' [[gene]].<ref name="pmid9435697">{{cite journal | vauthors = Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM | title = Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization | journal = Am J Physiol | volume = 273 | issue = 6 Pt 2 | pages = F1058-65 |date=Feb 1998 | pmid = 9435697 | doi =  10.1152/ajprenal.1997.273.6.F1058}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC28A2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9153}}</ref>
 == See also ==
@@ Line 15: / Line 16: @@
 *{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
 *{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
-*{{cite journal  | vauthors=Ritzel MW, Yao SY, Ng AM |title=Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. |journal=Mol. Membr. Biol. |volume=15 |issue= 4 |pages= 203–11 |year= 1999 |pmid= 10087507 |doi=10.3109/09687689709044322  |display-authors=etal}}
+*{{cite journal  | vauthors=Ritzel MW, Yao SY, Ng AM |title=Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. |journal=Mol. Membr. Biol. |volume=15 |issue= 4 |pages= 203–11 |year= 1999 |pmid= 10087507 |doi=10.3109/09687689709044322  |display-authors=etal|doi-access=free }}
-*{{cite journal  | vauthors=Loewen SK, Ng AM, Yao SY |title=Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24475–84 |year= 1999 |pmid= 10455109 |doi=10.1074/jbc.274.35.24475  |display-authors=etal}}
+*{{cite journal  | vauthors=Loewen SK, Ng AM, Yao SY |title=Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24475–84 |year= 1999 |pmid= 10455109 |doi=10.1074/jbc.274.35.24475  |display-authors=etal|doi-access=free }}
 *{{cite journal  | vauthors=Pennycooke M, Chaudary N, Shuralyova I |title=Differential expression of human nucleoside transporters in normal and tumor tissue. |journal=Biochem. Biophys. Res. Commun. |volume=280 |issue= 3 |pages= 951–9 |year= 2001 |pmid= 11162617 |doi= 10.1006/bbrc.2000.4205 |display-authors=etal}}
-*{{cite journal  | vauthors=Li JY, Boado RJ, Pardridge WM |title=Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood–brain barrier. |journal=J. Pharmacol. Exp. Ther. |volume=299 |issue= 2 |pages= 735–40 |year= 2001 |pmid= 11602688 |doi=  }}
+*{{cite journal  | vauthors=Li JY, Boado RJ, Pardridge WM |title=Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood–brain barrier. |journal=J. Pharmacol. Exp. Ther. |volume=299 |issue= 2 |pages= 735–40 |year= 2001 |pmid= 11602688 }}
-*{{cite journal  | vauthors=Gerstin KM, Dresser MJ, Giacomini KM |title=Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 2 |pages= F344–9 |year= 2002 |pmid= 12110519 |doi= 10.1152/ajprenal.00274.2001 }}
+*{{cite journal  | vauthors=Gerstin KM, Dresser MJ, Giacomini KM |title=Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. |journal=Am. J. Physiol. Renal Physiol. |volume=283 |issue= 2 |pages= F344–9 |year= 2002 |pmid= 12110519 |doi= 10.1152/ajprenal.00274.2001 |s2cid=21332585 }}
-*{{cite journal  | vauthors=Molina-Arcas M, Bellosillo B, Casado FJ |title=Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. |journal=Blood |volume=101 |issue= 6 |pages= 2328–34 |year= 2003 |pmid= 12411296 |doi= 10.1182/blood-2002-07-2236 |display-authors=etal}}
+*{{cite journal  | vauthors=Molina-Arcas M, Bellosillo B, Casado FJ |title=Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia. |journal=Blood |volume=101 |issue= 6 |pages= 2328–34 |year= 2003 |pmid= 12411296 |doi= 10.1182/blood-2002-07-2236 |display-authors=etal|doi-access=free }}
-*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|display-authors=etal}}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
 *{{cite journal  | vauthors=Shin HC, Landowski CP, Sun D |title=Functional expression and characterization of a sodium-dependent nucleoside transporter hCNT2 cloned from human duodenum. |journal=Biochem. Biophys. Res. Commun. |volume=307 |issue= 3 |pages= 696–703 |year= 2003 |pmid= 12893280 |doi=10.1016/S0006-291X(03)01259-2  |display-authors=etal}}
-*{{cite journal  | vauthors=Lang TT, Young JD, Cass CE |title=Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line. |journal=Mol. Pharmacol. |volume=65 |issue= 4 |pages= 925–33 |year= 2004 |pmid= 15044622 |doi= 10.1124/mol.65.4.925 }}
+*{{cite journal  | vauthors=Lang TT, Young JD, Cass CE |title=Interactions of nucleoside analogs, caffeine, and nicotine with human concentrative nucleoside transporters 1 and 2 stably produced in a transport-defective human cell line. |journal=Mol. Pharmacol. |volume=65 |issue= 4 |pages= 925–33 |year= 2004 |pmid= 15044622 |doi= 10.1124/mol.65.4.925 |s2cid=5665725 }}
-*{{cite journal  | vauthors=Damaraju VL, Visser F, Zhang J |title=Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside. |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 273–9 |year= 2005 |pmid= 15486050 |doi= 10.1124/mol.104.004408 |display-authors=etal}}
+*{{cite journal  | vauthors=Damaraju VL, Visser F, Zhang J |title=Role of human nucleoside transporters in the cellular uptake of two inhibitors of IMP dehydrogenase, tiazofurin and benzamide riboside. |journal=Mol. Pharmacol. |volume=67 |issue= 1 |pages= 273–9 |year= 2005 |pmid= 15486050 |doi= 10.1124/mol.104.004408 |s2cid=3017992 |display-authors=etal}}
 *{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
-*{{cite journal  | vauthors=Owen RP, Gray JH, Taylor TR |title=Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. |journal=Pharmacogenet. Genomics |volume=15 |issue= 2 |pages= 83–90 |year= 2005 |pmid= 15861032 |doi=10.1097/01213011-200502000-00004  |display-authors=etal}}
+*{{cite journal  | vauthors=Owen RP, Gray JH, Taylor TR |title=Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2. |journal=Pharmacogenet. Genomics |volume=15 |issue= 2 |pages= 83–90 |year= 2005 |pmid= 15861032 |doi=10.1097/01213011-200502000-00004  |s2cid=12817964 |display-authors=etal}}
-*{{cite journal  | vauthors=Owen RP, Badagnani I, Giacomini KM |title=Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. |journal=J. Biol. Chem. |volume=281 |issue= 36 |pages= 26675–82 |year= 2006 |pmid= 16840788 |doi= 10.1074/jbc.M513421200 }}
+*{{cite journal  | vauthors=Owen RP, Badagnani I, Giacomini KM |title=Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2. |journal=J. Biol. Chem. |volume=281 |issue= 36 |pages= 26675–82 |year= 2006 |pmid= 16840788 |doi= 10.1074/jbc.M513421200 |doi-access= free }}
 *{{cite journal  | vauthors=Fernández-Veledo S, Jover R, Casado FJ |title=Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells. |journal=Biochem. Biophys. Res. Commun. |volume=353 |issue= 2 |pages= 381–8 |year= 2007 |pmid= 17187757 |doi= 10.1016/j.bbrc.2006.12.021 |display-authors=etal}}
-*{{cite journal  | vauthors=Smith KM, Slugoski MD, Cass CE |title=Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. |journal=Mol. Membr. Biol. |volume=24 |issue= 1 |pages= 53–64 |year= 2007 |pmid= 17453413 |doi= 10.1080/09687860600942534 |display-authors=etal}}
+*{{cite journal  | vauthors=Smith KM, Slugoski MD, Cass CE |title=Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3. |journal=Mol. Membr. Biol. |volume=24 |issue= 1 |pages= 53–64 |year= 2007 |pmid= 17453413 |doi= 10.1080/09687860600942534 |s2cid=20779608 |display-authors=etal}}
 *{{cite journal  | vauthors=Hirsh AJ, Stonebraker JR, van Heusden CA |title=Adenosine deaminase 1 and concentrative nucleoside transporters 2 and 3 regulate adenosine on the apical surface of human airway epithelia: implications for inflammatory lung diseases. |journal=Biochemistry |volume=46 |issue= 36 |pages= 10373–83 |year= 2007 |pmid= 17696452 |doi= 10.1021/bi7009647 |display-authors=etal}}
 *{{cite journal  | vauthors=Li L, Tan CM, Koo SH |title=Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians. |journal=Pharmacogenet. Genomics |volume=17 |issue= 9 |pages= 783–6 |year= 2007 |pmid= 17700367 |doi= 10.1097/FPC.0b013e3281c10e41 |display-authors=etal}}

Latest revision as of 08:13, 22 December 2023

See also

References

Further reading