Desmethylflunitrazepam
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ECHA InfoCard | 100.018.072 |
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Formula | C15H10FN3O3 |
Molar mass | 299.261 g·mol−1 |
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Desmethylflunitrazepam (Ro05-4435, fonazepam) is a benzodiazepine that is a metabolite of flunitrazepam.[1][2][3] It has an IC50 value of 1.499 nM for the GABAA receptor.[4][5]
See also
References
- ^ Ruud W. Busker; Gerard M.J.Beijersbergen van Henegouwen; Brigitta M.C. Kwee; Jos H.M. Winkens (May 1987). "Photobinding of flunitrazepam and its major photo-decomposition product N-desmethylflunitrazepam". International Journal of Pharmaceutics. 36 (2–3): 113–120. doi:10.1016/0378-5173(87)90145-1.
- ^ Janet K Coller; Andrew A Somogyi; Felix Bochner (November 1998). "Quantification of flunitrazepam's oxidative metabolites, 3-hydroxyflunitrazepam and desmethylflunitrazepam, in hepatic microsomal incubations by high-performance liquid chromatography". Journal of Chromatography B. 719 (1–2): 87–92. doi:10.1016/S0378-4347(98)00383-1. PMID 9869368.
- ^ Tansel Kilicarslan; Robert L. Haining; Allan E. Rettie; Usanda Busto; Rachel F. Tyndale; Edward M. Sellers (April 2001). "Flunitrazepam Metabolism by Cytochrome P450s 2C19 and 3A4". Drug Metabolism and Disposition. 29 (4): 460–465. PMID 11259331.
- ^ Desmond J. Maddalena; Graham A. R. Johnston (February 1995). "Prediction of Receptor Properties and Binding Affinity of Ligands to Benzodiazepine/GABAA Receptors Using Artificial Neural Networks". Journal of Medicinal Chemistry. 38 (4): 715–724. doi:10.1021/jm00004a017. PMID 7861419.
- ^ Sung-Sau So; Martin Karplus (December 1996). "Genetic Neural Networks for Quantitative Structure−Activity Relationships: Improvements and Application of Benzodiazepine Affinity for Benzodiazepine/GABAA Receptors". Journal of Medicinal Chemistry. 39 (26): 5246–5256. doi:10.1021/jm960536o. PMID 8978853.
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