This is an old revision of this page, as edited by 2600:1700:2780:27a0:4da3:25ef:f52d:2f44(talk) at 04:28, 6 October 2022(Used more accurate/factual wording. There should be a published chemical analysis to prove that the mushrooms did indeed contain psilomethoxin.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 04:28, 6 October 2022 by 2600:1700:2780:27a0:4da3:25ef:f52d:2f44(talk)(Used more accurate/factual wording. There should be a published chemical analysis to prove that the mushrooms did indeed contain psilomethoxin.)
It is a psychedelic tryptamine but very little is known about it. The only report of it in the chemical literature was a paper published by Marc Julia's group at the Pasteur Institute in 1965.[1] This paper reports a 10 step synthesis of 4-HO-5-MeO-DMT from ortho-vanillin. However, Alexander Shulgin has explained that it could be possible to cultivate 4-HO-5-MeO-DMT in psilocybin mushrooms by adding 5-MeO-DMT to the growing substrate of the fungus. This method was allegedly tested and proven with 5-MeO-DMT by members of the Church of Psilomethoxin in 2021[citation needed], and had previously been used successfully for changing DET into 4-HO-DET and 4-PO-DET, both of which had never before been found in nature.[2]
Manufacture, transportation, possession, and distribution of 4-HO-5-MeO-DMT in the United States may be illegal under the Federal Analogue Act due to its structural relation to psilocin, which is listed as a Schedule I narcotic under the Controlled Substances Act of 1970.
Due to the resemblance to the neurotoxin 4,5-dihydroxytryptamine,[3] there is some concern that this compound may share that neurotoxicity, though this has not been investigated.
References
^Julia M, Manoury P, Voillaume MC (1965). "[No 209 - Recherches en série indolique. XIV (*) - Sur des méthoxy-5 hydroxy-4, méthoxy-5 hydroxy-6 et méthoxy-7 hydroxy-6 tryptamines]". Bull Chim Soc Fr (in French): 1417–23.
^Gartz J (1989). "Biotransformation of tryptamine derivatives in mycelial cultures of Psilocybe". Journal of Basic Microbiology. 29 (6): 347–52. doi:10.1002/jobm.3620290608. PMID2614674.
^Björklund A, Nobin A, Stenevi U (December 1973). "The use of neurotoxic dihydroxytryptamines as tools for morphological studies and localized lesioning of central indolamine neurons". Zeitschrift für Zellforschung und Mikroskopische Anatomie. 145 (4): 479–501. doi:10.1007/BF00306720. PMID4774982. S2CID44044588.
(what is this?) (verify)