KCNV1: Difference between revisions
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'''Potassium voltage-gated channel subfamily V member 1''' is a [[protein]] that in humans is encoded by the ''KCNV1'' [[gene]].<ref name="pmid8670833">{{cite journal |vauthors=Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M | title = Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels | journal = EMBO J | volume = 15 | issue = 13 | pages = 3322–31 |date=Aug 1996 | pmid = 8670833 | pmc = 451895 | doi = }}</ref><ref name="pmid16382104">{{cite journal |vauthors=Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 473–508 |date=Dec 2005 | pmid = 16382104 | pmc = | doi = 10.1124/pr.57.4.10 }}</ref> The [[protein]] encoded by this gene is a [[voltage-gated potassium channel]] subunit.<ref name="pmid8670833" /><ref name="pmid16382104" /> |
'''Potassium voltage-gated channel subfamily V member 1''' is a [[protein]] that in humans is encoded by the ''KCNV1'' [[gene]].<ref name="pmid8670833">{{cite journal |vauthors=Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M | title = Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels | journal = EMBO J | volume = 15 | issue = 13 | pages = 3322–31 |date=Aug 1996 | pmid = 8670833 | pmc = 451895 | doi = }}</ref><ref name="pmid16382104">{{cite journal |vauthors=Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 473–508 |date=Dec 2005 | pmid = 16382104 | pmc = | doi = 10.1124/pr.57.4.10 }}</ref> The [[protein]] encoded by this gene is a [[voltage-gated potassium channel]] subunit.<ref name="pmid8670833" /><ref name="pmid16382104" /> |
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Common variations in the ''KCNV1'' gene have been associated with schizophrenia.<ref>{{Cite journal|last=Schizophrenia Working Group of the Psychiatric Genomics Consortium|date=2014-07-24|title=Biological insights from 108 schizophrenia-associated genetic loci|url=https://www.ncbi.nlm.nih.gov/pubmed/25056061|journal=Nature|volume=511|issue=7510|pages=421–427|doi=10.1038/nature13595|issn=1476-4687|pmc=PMC4112379|pmid=25056061}}</ref> |
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==References== |
==References== |
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Revision as of 21:14, 3 April 2017
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | KCNV1, HNKA, KCNB3, KV2.3, KV8.1, potassium voltage-gated channel modifier subfamily V member 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608164; MGI: 1914748; HomoloGene: 22811; GeneCards: KCNV1; OMA:KCNV1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Potassium voltage-gated channel subfamily V member 1 is a protein that in humans is encoded by the KCNV1 gene.[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.[5][6]
Common variations in the KCNV1 gene have been associated with schizophrenia.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164794 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022342 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattei MG, Lazdunski M (Aug 1996). "Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels". EMBO J. 15 (13): 3322–31. PMC 451895. PMID 8670833.
- ^ a b Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
- ^ Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014-07-24). "Biological insights from 108 schizophrenia-associated genetic loci". Nature. 511 (7510): 421–427. doi:10.1038/nature13595. ISSN 1476-4687. PMC 4112379. PMID 25056061.
{{cite journal}}: CS1 maint: PMC format (link)
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Sano A, Mikami M, Nakamura M, et al. (2002). "Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy". Epilepsia. 43 Suppl 9: 26–31. doi:10.1046/j.1528-1157.43.s.9.7.x. PMID 12383276.
- Ebihara M, Ohba H, Kikuchi M, Yoshikawa T (2004). "Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene". Gene. 325: 89–96. doi:10.1016/j.gene.2003.09.044. PMID 14697513.
- Salinas M, de Weille J, Guillemare E, et al. (1997). "Modes of regulation of shab K+ channel activity by the Kv8.1 subunit". J. Biol. Chem. 272 (13): 8774–80. doi:10.1074/jbc.272.13.8774. PMID 9079713.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
External links
- Kv8.1+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- KCNV1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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