CLIC6

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Chloride intracellular channel 6
Identifiers
Symbols CLIC6 ; CLIC1L
External IDs MGI2146607 HomoloGene43154 GeneCards: CLIC6 Gene
Orthologs
Species Human Mouse
Entrez 54102 209195
Ensembl ENSG00000159212 ENSMUSG00000022949
UniProt Q96NY7 Q8BHB9
RefSeq (mRNA) NM_053277 NM_172469
RefSeq (protein) NP_444507 NP_766057
Location (UCSC) Chr 21:
36.04 – 36.09 Mb
Chr 16:
92.49 – 92.54 Mb
PubMed search [1] [2]

Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[1][2]

This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[2]

Interactions[edit]

CLIC6 has been shown to interact with Dopamine receptor D3.[3]

See also[edit]

References[edit]

  1. ^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953. 
  2. ^ a b "Entrez Gene: CLIC6 chloride intracellular channel 6". 
  3. ^ Griffon, Nathalie; Jeanneteau Freddy; Prieur Fanny; Diaz Jorge; Sokoloff Pierre (Sep 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Res. Mol. Brain Res. (Netherlands) 117 (1): 47–57. doi:10.1016/S0169-328X(03)00283-3. ISSN 0169-328X. PMID 14499480. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.