MCOLN2

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Mucolipin 2
Identifiers
Symbols MCOLN2 ; TRP-ML2; TRPML2
External IDs OMIM607399 MGI1915529 HomoloGene12258 IUPHAR: TRPML2 GeneCards: MCOLN2 Gene
Orthologs
Species Human Mouse
Entrez 255231 68279
Ensembl ENSG00000153898 ENSMUSG00000011008
UniProt Q8IZK6 Q8K595
RefSeq (mRNA) NM_153259 NM_001005846
RefSeq (protein) NP_694991 NP_001005846
Location (UCSC) Chr 1:
85.39 – 85.46 Mb
Chr 3:
146.15 – 146.2 Mb
PubMed search [1] [2]

Mucolipin-2 also known as TRPML2 (transient receptor potential cation channel, mucolipin subfamily, member 2) is a protein that in humans is encoded by the MCOLN2 gene.[1] It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

TRPML2 is associated with the Arf6-regulated trafficking pathway and is involved in the intracellular transport of membranes and membrane proteins.[2]

See also[edit]

  • transient receptor potential cation channel, mucolipin subfamily, member 1 (MCOLN1)
  • transient receptor potential cation channel, mucolipin subfamily, member 3 (MCOLN3)

References[edit]

  1. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  2. ^ Karacsonyi C, Miguel AS, Puertollano R (October 2007). "Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APs". Traffic 8 (10): 1404–14. doi:10.1111/j.1600-0854.2007.00619.x. PMID 17662026. 

External links[edit]