AQP7

Aquaporin 7
Identifiers
Symbols	AQP7; AQP7L; AQP9; AQPap; MGC149555; MGC149556
External IDs	OMIM: 602974 MGI: 1314647 HomoloGene: 48000 GeneCards: AQP7 Gene
Gene Ontology Molecular function • transporter activity • water channel activity • glycerol channel activity • urea channel activity Cellular component • cytoplasm • plasma membrane • plasma membrane • integral to plasma membrane • cell-cell junction • ribonucleoprotein complex • brush border membrane Biological process • generation of precursor metabolites and energy • water transport • spermatogenesis • excretion • glycerol transport • urea transport • response to drug • transmembrane transport • renal water absorption Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	364	11832
Ensembl	ENSG00000165269	ENSMUSG00000028427
UniProt	O14520	Q5DX24
RefSeq (mRNA)	NM_001170	NM_007473.4
RefSeq (protein)	NP_001161	NP_031499.1
Location (UCSC)	Chr 9: 33.38 – 33.4 Mb	Chr 4: 40.98 – 41 Mb
PubMed search	[1]	[2]

Aquaporin-7 is a protein that in humans is encoded by the AQP7 gene.

Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function.

See also

• Aquaporin

Further reading

• Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated water transport". Proc. Soc. Exp. Biol. Med. 219 (3): 183–99. PMID 9824541. 
• Kuriyama H, Kawamoto S, Ishida N et al (1998). "Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability". Biochem. Biophys. Res. Commun. 241 (1): 53–8. doi:10.1006/bbrc.1997.7769. PMID 9405233. 
• Ishibashi K, Yamauchi K, Kageyama Y et al (1998). "Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping". Biochim. Biophys. Acta 1399 (1): 62–6. PMID 9714739. 
• Suzuki-Toyota F, Ishibashi K, Yuasa S (1999). "Immunohistochemical localization of a water channel, aquaporin 7 (AQP7), in the rat testis". Cell Tissue Res. 295 (2): 279–85. doi:10.1007/s004410051234. PMID 9931374. 
• Kondo H, Shimomura I, Kishida K et al (2002). "Human aquaporin adipose (AQPap) gene. Genomic structure, promoter analysis and functional mutation". Eur. J. Biochem. 269 (7): 1814–26. doi:10.1046/j.1432-1033.2002.02821.x. PMID 11952783. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Humphray SJ, Oliver K, Hunt AR et al (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081. 
• Fortna A, Kim Y, MacLaren E et al (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=449870. 
• Marrades MP, Milagro FI, Martínez JA, Moreno-Aliaga MJ (2006). "Differential expression of aquaporin 7 in adipose tissue of lean and obese high fat consumers". Biochem. Biophys. Res. Commun. 339 (3): 785–9. doi:10.1016/j.bbrc.2005.11.080. PMID 16325777. 
• Prudente S, Flex E, Morini E et al (2007). "A functional variant of the adipocyte glycerol channel aquaporin 7 gene is associated with obesity and related metabolic abnormalities". Diabetes 56 (5): 1468–74. doi:10.2337/db06-1389. PMID 17351148. 
• Ceperuelo-Mallafré V, Miranda M, Chacón MR et al (2007). "Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes". J. Clin. Endocrinol. Metab. 92 (9): 3640–5. doi:10.1210/jc.2007-0531. PMID 17566090. 

External links

• MeSH AQP7+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.