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Potassium channel, subfamily K, member 6
Symbols KCNK6 ; K2p6.1; KCNK8; TOSS; TWIK-2; TWIK2
External IDs OMIM603939 MGI1891291 HomoloGene31266 IUPHAR: 518 GeneCards: KCNK6 Gene
RNA expression pattern
PBB GE KCNK6 gnf1h00063 at tn.png
More reference expression data
Species Human Mouse
Entrez 9424 52150
Ensembl ENSG00000099337 ENSMUSG00000046410
UniProt Q9Y257 E9PXN4
RefSeq (mRNA) NM_004823 NM_001033525
RefSeq (protein) NP_004814 NP_001028697
Location (UCSC) Chr 19:
38.81 – 38.82 Mb
Chr 7:
29.22 – 29.23 Mb
PubMed search [1] [2]

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.[1][2][3][4]

This gene encodes K2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.[4]

See also[edit]


  1. ^ Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem 274 (12): 7887–92. doi:10.1074/jbc.274.12.7887. PMID 10075682. 
  2. ^ Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet 84 (3–4): 190–1. doi:10.1159/000015255. PMID 10393428. 
  3. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  4. ^ a b "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.