Cation channels of sperm

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cation channel, sperm associated 1
Identifiers
Symbol CATSPER1
IUPHAR CatSper1
Entrez 117144
HUGO 17116
OMIM 606389
RefSeq NM_053054
UniProt Q8NEC5
Other data
Locus Chr. 11 q12.1
cation channel, sperm associated 2
Identifiers
Symbol CATSPER2
IUPHAR CatSper2
Entrez 117155
HUGO 18810
OMIM 607249
RefSeq NM_172097
UniProt Q96P55
Other data
Locus Chr. 15 q13-q15
cation channel, sperm associated 3
Identifiers
Symbol CATSPER3
IUPHAR CatSper3
Entrez 347732
HUGO 20819
OMIM 609120
RefSeq NM_178019
UniProt Q86XQ3
Other data
Locus Chr. 5 q31.2
cation channel, sperm associated 4
Identifiers
Symbol CATSPER4
IUPHAR CatSper4
Entrez 378807
HUGO 23220
OMIM 609121
RefSeq NM_198137
UniProt Q7RTX7
Other data
Locus Chr. 1 p35.3

The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract, CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization.[1] The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems.

See also[edit]

References[edit]

  1. ^ Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845. 

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