KCNK10
From Wikipedia, the free encyclopedia
| Potassium channel, subfamily K, member 10 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | KCNK10; FLJ43399; K2p10.1; TREK-2; TREK2 | ||||||||||||
| External IDs | OMIM: 605873 MGI: 1919508 HomoloGene: 11321 IUPHAR: K2P10.1 GeneCards: KCNK10 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54207 | 72258 | |||||||||||
| Ensembl | ENSG00000100433 | ENSMUSG00000033854 | |||||||||||
| UniProt | P57789 | Q8BUW1 | |||||||||||
| RefSeq (mRNA) | NM_021161.4 | NM_029911.4 | |||||||||||
| RefSeq (protein) | NP_066984.1 | NP_084187.2 | |||||||||||
| Location (UCSC) | Chr 14: 88.65 – 88.79 Mb |
Chr 12: 99.67 – 99.82 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Potassium channel, subfamily K, member 10, also known as KCNK10 is a human gene. The protein encoded by this gene, K2P10.1, is a potassium channel containing two pore-forming P domains.[1][2]
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[edit] See also
[edit] References
- ^ Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000). "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors". J. Biol. Chem. 275 (37): 28398–405. doi:10.1074/jbc.M002822200. PMID 10880510.
- ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106.
[edit] Further reading
- Gu W, Schlichthörl G, Hirsch JR et al (2002). "Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2". J. Physiol. (Lond.) 539 (Pt 3): 657–68. doi:10.1113/jphysiol.2001.013432. PMC 2290188. PMID 11897838. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2290188.
- Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078.
- Gierten J, Ficker E, Bloehs R et al (2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". Br. J. Pharmacol. 154 (8): 1680–90. doi:10.1038/bjp.2008.213. PMC 2518462. PMID 18516069. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2518462.
- Yu W, Andersson B, Worley KC et al (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
- Huang D, Yu B (2008). "Recent advance and possible future in TREK-2: a two-pore potassium channel may involved in the process of NPP, brain ischemia and memory impairment". Med. Hypotheses 70 (3): 618–24. doi:10.1016/j.mehy.2007.06.016. PMID 17689202.
- Andersson B, Wentland MA, Ricafrente JY et al (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Strausberg RL, Feingold EA, Grouse LH et al (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Bang H, Kim Y, Kim D (2000). "TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family". J. Biol. Chem. 275 (23): 17412–9. doi:10.1074/jbc.M000445200. PMID 10747911.
[edit] External links
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