KvLQT3

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Potassium voltage-gated channel, KQT-like subfamily, member 3
Identifiers
Symbols KCNQ3 ; BFNC2; EBN2; KV7.3
External IDs OMIM602232 MGI1336181 HomoloGene20949 IUPHAR: Kv7.3 ChEMBL: 2684 GeneCards: KCNQ3 Gene
RNA expression pattern
PBB GE KCNQ3 206573 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3786 110862
Ensembl ENSG00000184156 ENSMUSG00000056258
UniProt O43525 Q8K3F6
RefSeq (mRNA) NM_001204824 NM_152923
RefSeq (protein) NP_001191753 NP_690887
Location (UCSC) Chr 8:
133.13 – 133.49 Mb
Chr 15:
65.99 – 66.29 Mb
PubMed search [1] [2]

Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.[1]

It is associated with benign familial neonatal epilepsy.

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).[1]

Interactions[edit]

KvLQT3 has been shown to interact with KCNQ5.[2]

References[edit]

  1. ^ a b "Entrez Gene: KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3". 
  2. ^ Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience (United States) 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. ISSN 0306-4522. PMID 12890507. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.