KCNK4

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Potassium channel, subfamily K, member 4
TRAAK.png
Crystallographic structure of TRAAK. The gray boxes indicate approximate location of the lipid bilayer.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KCNK4 ; K2p4.1; TRAAK; TRAAK1
External IDs OMIM605720 MGI1298234 HomoloGene7391 IUPHAR: K2P4.1 GeneCards: KCNK4 Gene
RNA expression pattern
PBB GE KCNK4 219883 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 50801 16528
Ensembl ENSG00000182450 ENSMUSG00000024957
UniProt Q9NYG8 O88454
RefSeq (mRNA) NM_016611 NM_008431
RefSeq (protein) NP_201567 NP_032457
Location (UCSC) Chr 11:
64.06 – 64.07 Mb
Chr 19:
6.93 – 6.93 Mb
PubMed search [1] [2]

Potassium channel subfamily K member 4 is a protein that in humans is encoded by the KCNK4 gene.[2][3][4]

Function[edit]

Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes the K2P4.1 protein, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P4.1 homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids.[4]

KCNK4 protein channels are also called TRAAK channels. TRAAK channels are found in mammalian neurons and are part of a protein family of weakly inward rectifying potassium channels. This subfamily of potassium channels is mechanically gated. The C-terminal of TRAAK has a charged cluster that is important in maintaining the mechanosensitive properties of the channel.[5]

TRAAK is only expressed in neuronal tissue, and can be found in the brain, spinal cord, and retina, which suggests that it has a function beyond mechanotransduction in terms of neuronal excitability.[6] The highest levels of TRAAK expression are in the olfactory system, cerebral cortex, hippocampal formation, habenula, basal ganglia, and cerebellum.[6] TRAAK channels are mechanically activated when there is a convex curvature in the membrane that alters the channel’s activity. TRAAK channels are thought to have a role in axonal pathfinding, growth cone motility, and neurite elongation, as well as possibly having a role in touch or pain detection.[7][8]

See also[edit]

References[edit]

  1. ^ PDB 3UM7; Brohawn SG, del Mármol J, MacKinnon R (27 January 2012). "Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel". Science 335 (6067): 436–41. doi:10.1126/science.1213808. PMID 22282805. 
  2. ^ Lesage F, Maingret F, Lazdunski M (May 2000). "Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel". FEBS Lett 471 (2–3): 137–40. doi:10.1016/S0014-5793(00)01388-0. PMID 10767409. 
  3. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. doi:10.1124/pr.57.4.12. PMID 16382106. 
  4. ^ a b "Entrez Gene: KCNK4 potassium channel, subfamily K, member 4". 
  5. ^ Patel AJ, Honoré E, Lesage F, Fink M, Romey G, Lazdunski M (1999). "Inhalational anesthetics activate two-pore-domain background K+ channels". Nature Neuroscience 2 (5): 422–426. doi:10.1038/8084. PMID 10321245.  edit
  6. ^ a b Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M (1998). "A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids". The EMBO Journal 17 (12): 3297–3308. doi:10.1093/emboj/17.12.3297. PMC 1170668. PMID 9628867.  edit
  7. ^ Vandorpe DH, Morris CE (1992). "Stretch activation of the Aplysia S-channel". The Journal of membrane biology 127 (3): 205–214. PMID 1495087.  edit
  8. ^ Maingret F, Fosset M, Lesage F, Lazdunski M, Honoré E (1999). "TRAAK is a mammalian neuronal mechano-gated K+ channel". The Journal of Biological Chemistry 274 (3): 1381–1387. PMID 9880510.  edit

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.