KCNJ16

Potassium inwardly-rectifying channel, subfamily J, member 16
Identifiers
Symbols	KCNJ16; BIR9; KIR5.1; MGC33717
External IDs	OMIM: 605722 MGI: 1314842 HomoloGene: 23112 IUPHAR: Kir5.1 GeneCards: KCNJ16 Gene
Gene Ontology Molecular function • inward rectifier potassium channel activity • voltage-gated ion channel activity Cellular component • plasma membrane • voltage-gated potassium channel complex • integral to membrane Biological process • ion transport • potassium ion transport • synaptic transmission Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3773	16517
Ensembl	ENSG00000153822	ENSMUSG00000051497
UniProt	Q9NPI9	Q8BH37
RefSeq (mRNA)	NM_018658.1	NM_010604.3
RefSeq (protein)	NP_061128.1	NP_034734.3
Location (UCSC)	Chr 17: 68.07 – 68.13 Mb	Chr 11: 110.83 – 110.89 Mb
PubMed search	[1]	[2]

Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the K_ir5.1 protein.

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. K_ir5.1 is an integral membrane protein and inward-rectifier type potassium channel. K_ir5.1, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, can form heterodimers with two other inward-rectifier type potassium channels. It may be involved in the regulation of fluid and pH balance. Three transcript variants encoding the same protein have been found for this gene.

See also

• Inward-rectifier potassium ion channel

Further reading

• Kubo Y, Adelman JP, Clapham DE, et al. (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Pearson WL, Dourado M, Schreiber M, et al. (1999). "Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver". J. Physiol. (Lond.) 514 ( Pt 3) (3): 639–53. doi:10.1111/j.1469-7793.1999.639ad.x. PMC 2269105. PMID 9882736. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2269105. 
• Liu Y, McKenna E, Figueroa DJ, et al. (2000). "The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas". Cytogenet. Cell Genet. 90 (1–2): 60–3. doi:10.1159/000015662. PMID 11060447. 
• Derst C, Karschin C, Wischmeyer E, et al. (2001). "Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits". FEBS Lett. 491 (3): 305–11. doi:10.1016/S0014-5793(01)02202-5. PMID 11240146. 
• Pessia M, Imbrici P, D'Adamo MC, et al. (2001). "Differential pH sensitivity of Kir4.1 and Kir4.2 potassium channels and their modulation by heteropolymerisation with Kir5.1". J. Physiol. (Lond.) 532 (Pt 2): 359–67. doi:10.1111/j.1469-7793.2001.0359f.x. PMC 2278540. PMID 11306656. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2278540. 
• Tanemoto M, Fujita A, Higashi K, Kurachi Y (2002). "PSD-95 mediates formation of a functional homomeric Kir5.1 channel in the brain". Neuron 34 (3): 387–97. doi:10.1016/S0896-6273(02)00675-X. PMID 11988170. 
• Konstas AA, Korbmacher C, Tucker SJ (2003). "Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels". Am. J. Physiol., Cell Physiol. 284 (4): C910–7. doi:10.1152/ajpcell.00479.2002. PMID 12456399. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Casamassima M, D'Adamo MC, Pessia M, Tucker SJ (2003). "Identification of a heteromeric interaction that influences the rectification, gating, and pH sensitivity of Kir4.1/Kir5.1 potassium channels". J. Biol. Chem. 278 (44): 43533–40. doi:10.1074/jbc.M306596200. PMID 12923169. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.