KCNAB1

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Potassium voltage-gated channel, shaker-related subfamily, beta member 1
Identifiers
Symbols KCNAB1 ; AKR6A3; KCNA1B; KV-BETA-1; Kvb1.3; hKvBeta3; hKvb3
External IDs OMIM601141 MGI109155 HomoloGene56491 ChEMBL: 5884 GeneCards: KCNAB1 Gene
RNA expression pattern
PBB GE KCNAB1 210078 s at tn.png
PBB GE KCNAB1 208213 s at tn.png
PBB GE KCNAB1 210079 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7881 16497
Ensembl ENSG00000169282 ENSMUSG00000027827
UniProt Q14722 P63143
RefSeq (mRNA) NM_003471 NM_010597
RefSeq (protein) NP_003462 NP_034727
Location (UCSC) Chr 3:
155.76 – 156.26 Mb
Chr 3:
65.11 – 65.38 Mb
PubMed search [1] [2]

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.[1][2][3]

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms that are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.[3]

See also[edit]

References[edit]

  1. ^ Schultz D, Litt M, Smith L, Thayer M, McCormack K (Mar 1997). "Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B". Genomics 31 (3): 389–91. doi:10.1006/geno.1996.0065. PMID 8838324. 
  2. ^ England SK, Uebele VN, Kodali J, Bennett PB, Tamkun MM (Jan 1996). "A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing". J Biol Chem 270 (48): 28531–4. doi:10.1074/jbc.270.48.28531. PMID 7499366. 
  3. ^ a b "Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.