Voltage-gated proton channel

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Voltage-gated proton channels are ion channels that have the unique property of opening with depolarization, but in a strongly pH-sensitive manner.[1] The result is that these channels open only when the electrochemical gradient is outward, such that their opening will only allow protons to leave cells. Their function thus appears to be acid extrusion from cells.[2]

Another important function occurs in phagocytes (e.g. eosinophils, neutrophils, and macrophages) during the respiratory burst. When bacteria or other microbes are engulfed by phagocytes, the enzyme NADPH oxidase assembles in the membrane and begins to produce reactive oxygen species (ROS) that help kill bacteria.[3] NADPH oxidase is electrogenic,[4] moving electrons across the membrane, and proton channels open to allow proton flux to balance the electron movement electrically.[5]

Known types

References

  1. ^ Cherny, V.V.; Markin, V.S.; DeCoursey, T.E. (1995), "The voltage-activated hydrogen ion conductance in rat alveolar epithelial cells is determined by the pH gradient" (PDF), Journal of General Physiology, vol. 105, no. 6 (published June 1995), pp. 861–896, doi:10.1085/jgp.105.6.861, retrieved 2008-07-14
  2. ^ DeCoursey, T.E. (2003), "Voltage-gated proton channels and other proton transfer pathways", Physiological Reviews, vol. 83, no. 2, pp. 475–579, doi:10.1152/physrev.00028.2002, OCLC 205658168, PMID 12663866, retrieved 2008-07-14
  3. ^ Babior, B.M. (1999-03-01), "NADPH Oxidase: An Update." (PDF), Blood, vol. 93, no. 5, pp. 1464–1476, ISSN 1528-0020, retrieved 2008-07-14
  4. ^ Henderson, L.M.; Chappell, J.B.; Jones, O.T.G. (1987-09-01), "The superoxide-generating NADPH oxidase of human neutrophils is electrogenic and associated with an H+ channel" (PDF), The Biochemical Journal, vol. 246, no. 2, pp. 325–329, ISSN 0264-6021, OCLC 116254550, retrieved 2008-07-14
  5. ^ Murphy, R.; DeCoursey, T.E. (2006), "Charge compensation during the phagocyte respiratory burst", Biochimica et Biophysica Acta, Bioenergetics, vol. 1757, no. 8 (published 2006-08-08), pp. 996–1011, doi:10.1016/j.bbabio.2006.01.005, PMID 16483534 {{citation}}: |access-date= requires |url= (help)