Feminizing hormone therapy: Difference between revisions
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A 2018 cohort study of 2842 transfeminine individuals in the [[United States]] treated with a mean follow-up of 4.0 years observed an increased risk of VTE, [[stroke]], and [[heart attack]] relative to a cisgender reference population.<ref name="pmid30178031">{{cite journal | vauthors = Rosendale N, Goldman S, Ortiz GM, Haber LA | title = Acute Clinical Care for Transgender Patients: A Review | journal = JAMA Intern Med | volume = 178 | issue = 11 | pages = 1535–1543 | date = November 2018 | pmid = 30178031 | doi = 10.1001/jamainternmed.2018.4179 | s2cid = 52146607 | url = }}</ref><ref name="pmid30334572">{{cite journal | vauthors = Speed V, Roberts LN, Patel JP, Arya R | title = Venous thromboembolism and women's health | journal = Br. J. Haematol. | volume = 183 | issue = 3 | pages = 346–363 | date = November 2018 | pmid = 30334572 | doi = 10.1111/bjh.15608 | s2cid = 52985304 | url = }}</ref><ref name="pmid30256230" /><ref name="pmid29987313">{{cite journal | vauthors = Getahun D, Nash R, Flanders WD, Baird TC, Becerra-Culqui TA, Cromwell L, Hunkeler E, Lash TL, Millman A, Quinn VP, Robinson B, Roblin D, Silverberg MJ, Safer J, Slovis J, Tangpricha V, Goodman M | title = Cross-sex Hormones and Acute Cardiovascular Events in Transgender Persons: A Cohort Study | journal = Ann. Intern. Med. | volume = 169 | issue = 4 | pages = 205–213 | date = August 2018 | pmid = 29987313 | pmc = 6636681 | doi = 10.7326/M17-2785 | url = }}</ref> The estrogens used included oral estradiol (1 to 10 mg/day) and other estrogen formulations.<ref name="pmid29987313" /> Other medications such as antiandrogens like spironolactone were also used.<ref name="pmid29987313" /> |
A 2018 cohort study of 2842 transfeminine individuals in the [[United States]] treated with a mean follow-up of 4.0 years observed an increased risk of VTE, [[stroke]], and [[heart attack]] relative to a cisgender reference population.<ref name="pmid30178031">{{cite journal | vauthors = Rosendale N, Goldman S, Ortiz GM, Haber LA | title = Acute Clinical Care for Transgender Patients: A Review | journal = JAMA Intern Med | volume = 178 | issue = 11 | pages = 1535–1543 | date = November 2018 | pmid = 30178031 | doi = 10.1001/jamainternmed.2018.4179 | s2cid = 52146607 | url = }}</ref><ref name="pmid30334572">{{cite journal | vauthors = Speed V, Roberts LN, Patel JP, Arya R | title = Venous thromboembolism and women's health | journal = Br. J. Haematol. | volume = 183 | issue = 3 | pages = 346–363 | date = November 2018 | pmid = 30334572 | doi = 10.1111/bjh.15608 | s2cid = 52985304 | url = }}</ref><ref name="pmid30256230" /><ref name="pmid29987313">{{cite journal | vauthors = Getahun D, Nash R, Flanders WD, Baird TC, Becerra-Culqui TA, Cromwell L, Hunkeler E, Lash TL, Millman A, Quinn VP, Robinson B, Roblin D, Silverberg MJ, Safer J, Slovis J, Tangpricha V, Goodman M | title = Cross-sex Hormones and Acute Cardiovascular Events in Transgender Persons: A Cohort Study | journal = Ann. Intern. Med. | volume = 169 | issue = 4 | pages = 205–213 | date = August 2018 | pmid = 29987313 | pmc = 6636681 | doi = 10.7326/M17-2785 | url = }}</ref> The estrogens used included oral estradiol (1 to 10 mg/day) and other estrogen formulations.<ref name="pmid29987313" /> Other medications such as antiandrogens like spironolactone were also used.<ref name="pmid29987313" /> |
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A 2019 [[systematic review]] and [[meta-analysis]] found an incidence rate of VTE of 2.3 per 1000 person-years with feminizing hormone therapy in transgender women.<ref name="pmid30602475">{{cite journal | vauthors = Khan J, Schmidt RL, Spittal MJ, Goldstein Z, Smock KJ, Greene DN | title = Venous Thrombotic Risk in Transgender Women Undergoing Estrogen Therapy: A Systematic Review and Metaanalysis | journal = Clin. Chem. | volume = 65 | issue = 1 | pages = 57–66 | date = January 2019 | pmid = 30602475 | doi = 10.1373/clinchem.2018.288316 | url = }}</ref> For comparison, the rate in the general population has been found to be 1.0–1.8 per 1000 person-years, and the rate in premenopausal women taking [[birth control pill]]s has been found to be 3.5 per 1000 patient-years.<ref name="pmid30602475" /><ref name="pmid26076949">{{cite journal | vauthors = Heit JA | title = Epidemiology of venous thromboembolism | journal = Nat Rev Cardiol | volume = 12 | issue = 8 | pages = 464–74 | date = August 2015 | pmid = 26076949 | pmc = 4624298 | doi = 10.1038/nrcardio.2015.83 | url = }}</ref |
A 2019 [[systematic review]] and [[meta-analysis]] found an incidence rate of VTE of 2.3 per 1000 person-years with feminizing hormone therapy in transgender women.<ref name="pmid30602475">{{cite journal | vauthors = Khan J, Schmidt RL, Spittal MJ, Goldstein Z, Smock KJ, Greene DN | title = Venous Thrombotic Risk in Transgender Women Undergoing Estrogen Therapy: A Systematic Review and Metaanalysis | journal = Clin. Chem. | volume = 65 | issue = 1 | pages = 57–66 | date = January 2019 | pmid = 30602475 | doi = 10.1373/clinchem.2018.288316 | url = }}</ref> For comparison, the rate in the general population has been found to be 1.0–1.8 per 1000 person-years, and the rate in premenopausal women taking [[birth control pill]]s has been found to be 3.5 per 1000 patient-years.<ref name="pmid30602475" /><ref name="pmid26076949">{{cite journal | vauthors = Heit JA | title = Epidemiology of venous thromboembolism | journal = Nat Rev Cardiol | volume = 12 | issue = 8 | pages = 464–74 | date = August 2015 | pmid = 26076949 | pmc = 4624298 | doi = 10.1038/nrcardio.2015.83 | url = }}</ref> There was significant [[heterogeneity]] in the rates of VTE across the included studied, and the meta-analysis was unable to perform subgroup analyses between estrogen type, estrogen route, estrogen dosage, concomitant antiandrogen or progestogen use, or patient characteristics (e.g., sex, age, smoking status, weight) corresponding to known risk factors for VTE.<ref name="pmid30602475" /> Due to the inclusion of some studies using ethinylestradiol, which is more thrombotic and is no longer used in transgender women, the researchers noted that the VTE risk found in their study may be an overestimate.<ref name="pmid30602475" /> |
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In a 2016 study that specifically assessed oral estradiol, the incidence of VTE in 676 transgender women who were treated for an average of 1.9 years each was only one individual, or 0.15% of the group, with an incidence of 7.8 events per 10,000 person-years.<ref name="Houlberg2019">{{cite book|last1=Houlberg|first1=Magda|title=Transgender and Gender Nonconforming Health and Aging|chapter=Endocrinology, Hormone Replacement Therapy (HRT), and Aging|year=2019|pages=21–35|doi=10.1007/978-3-319-95031-0_2|isbn=978-3-319-95030-3}}</ref><ref name="pmid27671969">{{cite journal | vauthors = Arnold JD, Sarkodie EP, Coleman ME, Goldstein DA | title = Incidence of Venous Thromboembolism in Transgender Women Receiving Oral Estradiol | journal = J Sex Med | volume = 13 | issue = 11 | pages = 1773–1777 | date = November 2016 | pmid = 27671969 | doi = 10.1016/j.jsxm.2016.09.001 | url = }}</ref> The dosage of oral estradiol used was 2 to 8 mg/day.<ref name="pmid27671969" /> Almost all of the transgender women were also taking spironolactone (94%), a subset were also taking finasteride (17%), and fewer than 5% were also taking a progestogen (usually oral progesterone).<ref name="pmid27671969" /> The findings of this study suggest that the incidence of VTE is low in transgender women taking oral estradiol.<ref name="Houlberg2019" /><ref name="pmid27671969" /> |
In a 2016 study that specifically assessed oral estradiol, the incidence of VTE in 676 transgender women who were treated for an average of 1.9 years each was only one individual, or 0.15% of the group, with an incidence of 7.8 events per 10,000 person-years.<ref name="Houlberg2019">{{cite book|last1=Houlberg|first1=Magda|title=Transgender and Gender Nonconforming Health and Aging|chapter=Endocrinology, Hormone Replacement Therapy (HRT), and Aging|year=2019|pages=21–35|doi=10.1007/978-3-319-95031-0_2|isbn=978-3-319-95030-3}}</ref><ref name="pmid27671969">{{cite journal | vauthors = Arnold JD, Sarkodie EP, Coleman ME, Goldstein DA | title = Incidence of Venous Thromboembolism in Transgender Women Receiving Oral Estradiol | journal = J Sex Med | volume = 13 | issue = 11 | pages = 1773–1777 | date = November 2016 | pmid = 27671969 | doi = 10.1016/j.jsxm.2016.09.001 | url = }}</ref> The dosage of oral estradiol used was 2 to 8 mg/day.<ref name="pmid27671969" /> Almost all of the transgender women were also taking spironolactone (94%), a subset were also taking finasteride (17%), and fewer than 5% were also taking a progestogen (usually oral progesterone).<ref name="pmid27671969" /> The findings of this study suggest that the incidence of VTE is low in transgender women taking oral estradiol.<ref name="Houlberg2019" /><ref name="pmid27671969" /> |
Revision as of 09:36, 21 September 2020
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Transgender hormone therapy of the male-to-female (MTF) type, also known as transfeminine hormone therapy, is hormone therapy and sex reassignment therapy to change the secondary sexual characteristics of transgender people from masculine or androgynous to feminine.[1][2][3][4][5][6] It is one of two types of transgender hormone therapy (the other being female-to-male) and is predominantly used to treat transgender women and other transfeminine individuals. Some intersex people also take this form of therapy, according to their personal needs and preferences.
The purpose of the therapy is to cause the development of the secondary sex characteristics of the desired sex, such as breasts and a feminine pattern of hair, fat, and muscle distribution. It cannot undo many of the changes produced by naturally occurring puberty, which may necessitate surgery and other treatments to reverse (see below). The medications used for the MTF therapy include estrogens, antiandrogens, progestogens, and gonadotropin-releasing hormone modulators (GnRH modulators).
While the therapy cannot undo the effects of a person's first puberty, developing secondary sex characteristics associated with one's gender has been shown to relieve some or all of the distress and discomfort associated with gender dysphoria, and can help the person to "pass" or be seen as their gender.[7] Introducing exogenous hormones into the body impacts it at every level and many patients report changes in energy levels, mood, appetite, etc. The goal of the therapy is to provide patients with a more satisfying body that is more congruent with their gender identity.
Medical uses
- To produce feminization and/or demasculinization in transgender women and transfeminine non-binary individuals.
- To produce feminization and/or demasculinization in intersex people.
Requirements
Many physicians operate by the World Professional Association of Transgender Health (WPATH) Standards of Care (SoC) model and require psychotherapy and a letter of recommendation from a psychotherapist in order for a transgender person to obtain hormone therapy.[2] Other physicians operate by an informed consent model and have no requirements for transgender hormone therapy aside from consent.[2] Medications used in transgender hormone therapy are also sold without a prescription on the Internet by unregulated online pharmacies, and some transgender women purchase these medications and treat themselves using a do-it-yourself (DIY) or self-medication approach.[8][9] Many transgender individuals discuss and share information on DIY hormone therapy on Reddit communities such as /r/TransDIY and /r/MtFHRT.[8][9][10][11] One reason that many transgender people turn to DIY hormone therapy is due to long waiting lists of up to years for standard physician-based hormone therapy in some parts of the world such as the United Kingdom, as well as due to the often high costs of seeing a physician.[8][9]
The accessibility of transgender hormone therapy differs throughout the world and throughout individual countries.[2]
Contraindications
This section needs additional citations for verification. (December 2018) |
Some medical conditions may be a reason to not to take feminizing hormone therapy because of the harm it could cause to the individual. Such interfering factors are described in medicine as contraindications.
Absolute contraindications – those that can cause life-threatening complications, and in which feminizing hormone therapy should never be used – include histories of estrogen-sensitive cancer (e.g., breast cancer), thrombosis or embolism (unless the patient receives concurrent anticoagulants), or macroprolactinoma.[citation needed] In such cases, the patient should be monitored by an oncologist, hematologist or cardiologist, or neurologist, respectively.
Relative contraindications – in which the benefits of HRT may outweigh the risks, but caution should be used – include:
- Liver disease, kidney disease, heart disease, or stroke
- Risk factors for heart disease, such as high cholesterol, diabetes, obesity, or smoking
- Family history of breast cancer or thromboembolic disease
- Gallbladder disease
- Circulation or clotting conditions, such as peripheral vascular disease, polycythemia vera, sickle-cell anemia, paroxysmal nocturnal hemoglobinuria, hyperlipidemia, hypertension, factor V Leiden, prothrombin mutation, antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulants, plasminogen or fibrinolysis disorders, protein C deficiency, protein S deficiency, or antithrombin III deficiency.
As dosages increase, risks increase as well. Therefore, patients with relative contraindications may start at low dosages and increase gradually.[citation needed]
Medications
A variety of different sex-hormonal medications are used in feminizing hormone therapy for transgender women.[1][2][3][4] These include estrogens to induce feminization and suppress testosterone levels; antiandrogens such as androgen receptor antagonists, antigonadotropins, GnRH modulators, and 5α-reductase inhibitors to further oppose the effects of androgens like testosterone; and progestogens for various possible though uncertain benefits.[1][2][3][4] An estrogen in combination with an antiandrogen is the mainstay of feminizing hormone therapy for transgender women.[12][13]
Medication | Brand name | Type | Route | Dosage[b] |
---|---|---|---|---|
Estradiol | Various | Estrogen | Oral | 2–10 mg/day |
Various | Estrogen | Sublingual | 1–8 mg/day | |
Climara[c] | Estrogen | TD patch | 25–400 μg/day | |
Divigel[c] | Estrogen | TD gel | 0.5–5 mg/day | |
Various | Estrogen | SC implant | 50–200 mg every 6–24 mos | |
Estradiol valerate | Progynova | Estrogen | Oral | 2–10 mg/day |
Progynova | Estrogen | Sublingual | 1–8 mg/day | |
Delestrogen[c] | Estrogen | IM, SC | 2–10 mg/wk or 5–20 mg every 2 wks | |
Estradiol cypionate | Depo-Estradiol | Estrogen | IM, SC | 2–10 mg/wk or 5–20 mg every 2 wks |
Estradiol dipropionate | Agofollin | Estrogen | IM, SC | 2–10 mg/wk or 5–20 mg every 2 wks |
Estradiol benzoate | Progynon-B | Estrogen | IM, SC | 0.5–1.5 mg every 2–3 days |
Estriol | Ovestin[c] | Estrogen | Oral | 4–6 mg/day |
Spironolactone | Aldactone | Antiandrogen | Oral | 100–400 mg/day |
Cyproterone acetate | Androcur | Antiandrogen; Progestogen |
Oral | 5–100 mg/day |
Androcur Depot | IM | 300 mg/month | ||
Bicalutamide | Casodex | Antiandrogen | Oral | 25–50 mg/day |
Enzalutamide | Xtandi | Antiandrogen | Oral | 160 mg/day |
GnRH analogue | Various | GnRH modulator | Various | Variable |
Elagolix | Orilissa | GnRH antagonist | Oral | 150 mg/day or 200 mg twice daily |
Finasteride | Propecia | 5αR inhibitor | Oral | 1–5 mg/day |
Dutasteride | Avodart | 5αR inhibitor | Oral | 0.25–0.5 mg/day |
Progesterone | Prometrium[c] | Progestogen | Oral | 100–400 mg/day |
Medroxyprogesterone acetate | Provera | Progestogen | Oral | 2.5–40 mg/day |
Depo-Provera | Progestogen | IM | 150 mg every 3 mos | |
Depo-SubQ Provera 104 | Progestogen | SC | 104 mg every 3 mos | |
Hydroxyprogesterone caproate | Proluton | Progestogen | IM | 250 mg/wk |
Dydrogesterone | Duphaston | Progestogen | Oral | 20 mg/day |
Drospirenone | Slynd | Progestogen | Oral | 3 mg/day |
Domperidone[d] | Motilium | Prolactin releaser | Oral | 30–80 mg/day[e] |
|
Estrogens
![](http://upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Estradiol_and_testosterone_levels_with_a_single_intramuscular_injection_of_320_mg_polyestradiol_phosphate_in_men.png/350px-Estradiol_and_testosterone_levels_with_a_single_intramuscular_injection_of_320_mg_polyestradiol_phosphate_in_men.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/3/31/Testosterone_levels_as_a_function_of_estradiol_levels_during_oral_estradiol_therapy_in_transgender_women.png/350px-Testosterone_levels_as_a_function_of_estradiol_levels_during_oral_estradiol_therapy_in_transgender_women.png)
Estrogens are the major sex hormones in women, and are responsible for the development and maintenance of feminine secondary sexual characteristics, such as breasts, wide hips, and a feminine pattern of fat distribution.[4] Estrogens act by binding to and activating the estrogen receptor (ER), their biological target in the body.[47] A variety of different forms of estrogens are available and used medically.[47] The most common estrogens used in transgender women include estradiol, which is the predominant natural estrogen in women, and estradiol esters such as estradiol valerate and estradiol cypionate, which are prodrugs of estradiol.[1][4][47] Conjugated estrogens (Premarin), which are used in menopausal hormone therapy, and ethinylestradiol, which is used in birth control pills, have been used in transgender women in the past, but are no longer recommended and are rarely used today due to their higher risks of blood clots and cardiovascular problems.[4][1][2][5] Estrogens may be administered orally, sublingually, transdermally/topically (via patch or gel), rectally, by intramuscular or subcutaneous injection, or by an implant.[47][15][48][49][50] Parenteral (non-oral) routes are preferred, owing to a minimal or negligible risk of blood clots and cardiovascular issues.[5][51][52][53][54]
In addition to producing feminization, estrogens have antigonadotropic effects and suppress gonadal sex hormone production.[15][46][26] They are mainly responsible for the suppression of testosterone levels in transgender women.[15][26] Levels of estradiol of 200 pg/mL and above suppress testosterone levels by about 90%, while estradiol levels of 500 pg/mL and above suppress testosterone levels by about 95%, or to an equivalent extent as surgical castration and GnRH modulators.[55][56] Lower levels of estradiol can also considerably but incompletely suppress testosterone production.[46] When testosterone levels are insufficiently suppressed by estradiol alone, antiandrogens can be used to suppress or block the effects of residual testosterone.[15] Oral estradiol often has difficulty adequately suppressing testosterone levels, due to the relatively low estradiol levels achieved with it.[46][57][58]
Prior to orchiectomy (surgical removal of the gonads) or sex reassignment surgery, the doses of estrogens used in transgender women are often higher than replacement doses used in cisgender women.[59][60][61] This is to help suppress testosterone levels.[60] The Endocrine Society (2017) recommends maintaining estradiol levels roughly within the normal average range for premenopausal women of about 100 to 200 pg/mL.[1] However, it notes that these physiological levels of estradiol are usually unable to suppress testosterone levels into the female range.[1] A 2018 Cochrane review proposal questioned the notion of keeping estradiol levels lower in transgender women, which results in incomplete suppression of testosterone levels and necessitates the addition of antiandrogens.[62] The review proposal noted that high-dose parenteral estradiol is known to be safe.[62] The Endocrine Society itself recommends dosages of injected estradiol esters that result in estradiol levels markedly in excess of the normal female range, for instance 10 mg per week estradiol valerate by intramuscular injection.[1] A single such injection results in estradiol levels of about 1,250 pg/mL at peak and levels of around 200 pg/mL after 7 days.[63][64] Dosages of estrogens can be reduced after an orchiectomy or sex reassignment surgery, when gonadal testosterone suppression is no longer needed.[5]
Antiandrogens
Antiandrogens are medications that prevent the effects of androgens in the body.[65][66] Androgens, such as testosterone and dihydrotestosterone (DHT), are the major sex hormones in individuals with testes, and are responsible for the development and maintenance of masculine secondary sex characteristics, such as a deep voice, broad shoulders, and a masculine pattern of hair, muscle, and fat distribution.[67][68] In addition, androgens stimulate sex drive and the frequency of spontaneous erections and are responsible for acne, body odor, and androgen-dependent scalp hair loss.[67][68] They also have functional antiestrogenic effects in the breasts and oppose estrogen-mediated breast development, even at low levels.[69][70][71][72] Androgens act by binding to and activating the androgen receptor, their biological target in the body.[73] Antiandrogens work by blocking androgens from binding to the androgen receptor and/or by inhibiting or suppressing the production of androgens.[65]
Antiandrogens that directly block the androgen receptor are known as androgen receptor antagonists or blockers, while antiandrogens that inhibit the enzymatic biosynthesis of androgens are known as androgen synthesis inhibitors and antiandrogens that suppress androgen production in the gonads are known as antigonadotropins.[66] Estrogens and progestogens are antigonadotropins and hence are functional antiandrogens.[15][74][75][76] The purpose of the use of antiandrogens in transgender women is to block or suppress residual testosterone that is not suppressed by estrogens alone.[15][65][26] Additional antiandrogen therapy is not necessarily required if testosterone levels are in the normal female range or if the person has undergone orchiectomy.[15][65][26] However, individuals with testosterone levels in the normal female range and with persisting androgen-dependent skin and/or hair symptoms, such as acne, seborrhea, oily skin, or scalp hair loss, can potentially still benefit from the addition of an antiandrogen, as antiandrogens can reduce or eliminate such symptoms.[77][78][79]
Steroidal antiandrogens
Steroidal antiandrogens are antiandrogens that resemble steroid hormones like testosterone and progesterone in chemical structure.[80] They are the most commonly used antiandrogens in transgender women.[2] Spironolactone (Aldactone), which is relatively safe and inexpensive, is the most frequently used antiandrogen in the United States.[81][82] Cyproterone acetate (Androcur), which is unavailable in the United States, is widely used in Europe, Canada, and the rest of the world.[2][65][81][83] Medroxyprogesterone acetate (Provera, Depo-Provera), a similar medication, is sometimes used in place of cyproterone acetate in the United States.[84][85]
![](http://upload.wikimedia.org/wikipedia/commons/thumb/1/17/Testosterone_levels_with_estradiol_alone%2C_estradiol_plus_spironolactone%2C_and_estradiol_plus_cyproterone_acetate_in_transfeminine_people.png/300px-Testosterone_levels_with_estradiol_alone%2C_estradiol_plus_spironolactone%2C_and_estradiol_plus_cyproterone_acetate_in_transfeminine_people.png)
Spironolactone is an antimineralocorticoid (antagonist of the mineralocorticoid receptor) and potassium-sparing diuretic, which is mainly used to treat high blood pressure, edema, high aldosterone levels, and low potassium levels caused by other diuretics, among other uses.[87] Spironolactone is an antiandrogen as a secondary and originally unintended action.[87] It works as an antiandrogen mainly by acting as an androgen receptor antagonist.[88] The medication is also a weak steroidogenesis inhibitor, and inhibits the enzymatic synthesis of androgens.[89][88][90] However, this action is of low potency, and spironolactone has mixed and inconsistent effects on hormone levels.[89][88][90][91][92] In any case, testosterone levels are usually unchanged by spironolactone.[89][88][90][91][92] Studies in transgender women have found testosterone levels to be unaltered with spironolactone[46] or to be decreased.[86] Spironolactone is described as a relatively weak antiandrogen.[93][94][95] It is widely used in the treatment of acne, excessive hair growth, and hyperandrogenism in women, who have much lower testosterone levels than men.[91][92] Because of its antimineralocorticoid activity, spironolactone has antimineralocorticoid side effects[96] and can cause high potassium levels.[97][98] Hospitalization and/or death can potentially result from high potassium levels due to spironolactone,[97][98][99] but the risk of high potassium levels in people taking spironolactone appears to be minimal in those without risk factors for it.[92][100][101] As such, monitoring of potassium levels may not be necessary in most cases.[92][100][101] Spironolactone has been found to decrease the bioavailability of high doses of oral estradiol.[46] Although widely employed, the use of spironolactone as an antiandrogen in transgender women has recently been questioned due to the various shortcomings of the medication for such purposes.[46]
![](http://upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Testosterone_and_luteinizing_hormone_levels_with_100_mg_per_day_oral_cyproterone_acetate_in_men.png/300px-Testosterone_and_luteinizing_hormone_levels_with_100_mg_per_day_oral_cyproterone_acetate_in_men.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Testosterone_levels_with_100_to_300_mg_per_day_oral_cyproterone_acetate_and_0.1_mg_per_day_diethylstilbestrol_in_men.png/300px-Testosterone_levels_with_100_to_300_mg_per_day_oral_cyproterone_acetate_and_0.1_mg_per_day_diethylstilbestrol_in_men.png)
Cyproterone acetate is an antiandrogen and progestin which is used in the treatment of numerous androgen-dependent conditions and is also used as a progestogen in birth control pills.[105][106] It works primarily as an antigonadotropin, secondarily to its potent progestogenic activity, and strongly suppresses gonadal androgen production.[105][26] Cyproterone acetate at a dosage of 5 to 10 mg/day has been found to lower testosterone levels in men by about 50 to 70%,[107][108][109][110] while a dosage of 100 mg/day has been found to lower testosterone levels in men by about 75%.[111][112] The combination of 25 mg/day cyproterone acetate and a moderate dosage of estradiol has been found to suppress testosterone levels in transgender women by about 95%.[113] In combination with estrogen, 10, 25, and 50 mg/day cyproterone acetate have all shown the same degree of testosterone suppression.[114] In addition to its actions as an antigonadotropin, cyproterone acetate is an androgen receptor antagonist.[105][65] However, this action is relatively insignificant at low dosages, and is more important at the high doses of cyproterone acetate that are used in the treatment of prostate cancer (100–300 mg/day).[115][116] Cyproterone acetate can cause elevated liver enzymes and liver damage, including liver failure.[65][117] However, this occurs mostly in prostate cancer patients who take very high doses of cyproterone acetate; liver toxicity has not been reported in transgender women.[65] Cyproterone acetate also has a variety of other adverse effects, such as fatigue and weight gain, and risks, such as blood clots and benign brain tumors, among others.[26][65][118] Periodic monitoring of liver enzymes and prolactin levels may be advisable during cyproterone acetate therapy.
Medroxyprogesterone acetate is a progestin that is related to cyproterone acetate and is sometimes used as an alternative to it.[84][85] It is specifically used as an alternative to cyproterone acetate in the United States, where cyproterone acetate is not approved for medical use and is unavailable.[84][85] Medroxyprogesterone acetate suppresses testosterone levels in transgender women similarly to cyproterone acetate.[85][46] Oral medroxyprogesterone acetate has been found to suppress testosterone levels in men by about 30 to 75% across a dosage range of 20 to 100 mg/day.[119][120][121][122][123] In contrast to cyproterone acetate however, medroxyprogesterone acetate is not also an androgen receptor antagonist.[47][124] Medroxyprogesterone acetate has similar side effects and risks as cyproterone acetate, but is not associated with liver problems.[125][96]
Numerous other progestogens and by extension antigonadotropins have been used to suppress testosterone levels in men and are likely useful for such purposes in transgender women as well.[126][127][128][129][130][131][132] Progestogens alone are in general able to suppress testosterone levels in men by a maximum of about 70 to 80%, or to just above female/castrate levels when used at sufficiently high doses.[133][134][135] The combination of a sufficient dosage of a progestogen with very small doses of an estrogen (e.g., as little as 0.5–1.5 mg/day oral estradiol) is synergistic in terms of antigonadotropic effect and is able to fully suppress gonadal testosterone production, reducing testosterone levels to the female/castrate range.[104][136]
Nonsteroidal antiandrogens
Nonsteroidal antiandrogens are antiandrogens which are nonsteroidal and hence unrelated to steroid hormones in terms of chemical structure.[80][137] These medications are primarily used in the treatment of prostate cancer,[137] but are also used for other purposes such as the treatment of acne, excessive facial/body hair growth, and high androgen levels in women.[16][138][139][140] Unlike steroidal antiandrogens, nonsteroidal antiandrogens are highly selective for the androgen receptor and act as pure androgen receptor antagonists.[137][141] Similarly to spironolactone however, they do not lower androgen levels, and instead work exclusively by preventing androgens from activating the androgen receptor.[137][141] Nonsteroidal antiandrogens are more efficacious androgen receptor antagonists than are steroidal antiandrogens,[80][142] and for this reason, in conjunction with GnRH modulators, have largely replaced steroidal antiandrogens in the treatment of prostate cancer.[137][143]
The nonsteroidal antiandrogens that have been used in transgender women include the first-generation medications flutamide (Eulexin), nilutamide (Anandron, Nilandron), and bicalutamide (Casodex).[16][21][5][3][144]: 477 Newer and even more efficacious second-generation nonsteroidal antiandrogens like enzalutamide (Xtandi), apalutamide (Erleada), and darolutamide (Nubeqa) also exist, but are very expensive due to generics being unavailable and have not been used in transgender women.[145][146] Flutamide and nilutamide have relatively high toxicity, including considerable risks of liver damage and lung disease.[147][138] Due to its risks, the use of flutamide in cisgender and transgender women is now limited and discouraged.[16][138][5] Flutamide and nilutamide have largely been superseded by bicalutamide in clinical practice,[148][149] with bicalutamide accounting for almost 90% of nonsteroidal antiandrogen prescriptions in the United States by the mid-2000s.[150][141] Bicalutamide is said to have excellent tolerability and safety relative to flutamide and nilutamide, as well as in comparison to cyproterone acetate.[151][152][153] It has few to no side effects in women.[139][140] Despite its greatly improved tolerability and safety profile however, bicalutamide does still have a small risk of elevated liver enzymes and association with very rare cases of liver damage and lung disease.[16][147][154]
Nonsteroidal antiandrogens like bicalutamide may be a particularly favorable option for transgender women who wish to preserve sex drive, sexual function, and/or fertility, relative to antiandrogens that suppress testosterone levels and can greatly disrupt these functions such as cyproterone acetate and GnRH modulators.[155][156][157] However, estrogens suppress testosterone levels and at high doses can markedly disrupt sex drive and function and fertility on their own.[158][159][160][161] Moreover, disruption of gonadal function and fertility by estrogens may be permanent after extended exposure.[160][161]
GnRH modulators
GnRH modulators are powerful antigonadotropins and hence functional antiandrogens.[162] In both males and females, gonadotropin-releasing hormone (GnRH) is produced in the hypothalamus and induces the secretion of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland.[162] The gonadotropins signal the gonads to make sex hormones such as testosterone and estradiol.[162] GnRH modulators bind to and inhibit the GnRH receptor, thereby preventing gonadotropin release.[162] As a result of this, GnRH modulators are able to completely shut-down gonadal sex hormone production, and can decrease testosterone levels in men and transgender women by about 95%, or to an equivalent extent as surgical castration.[162][163][164] GnRH modulators are also commonly known as GnRH analogues.[162] However, not all clinically used GnRH modulators are analogues of GnRH.[165]
There are two types of GnRH modulators: GnRH agonists and GnRH antagonists.[162] These medications have the opposite action on the GnRH receptor but paradoxically have the same therapeutic effects.[162] GnRH agonists, such as leuprorelin (Lupron), goserelin (Zoladex), and buserelin (Suprefact), are GnRH receptor superagonists, and work by producing profound desensitization of the GnRH receptor such that the receptor becomes non-functional.[162][163] This occurs because GnRH is normally released in pulses, but GnRH agonists are continuously present, and this results in excessive downregulation of the receptor and ultimately a complete loss of function.[166][167][162] At the initiation of treatment, GnRH agonists are associated with a "flare" effect on hormone levels due to acute overstimulation of the GnRH receptor.[162][168] In men, LH levels increase by up to 800%, while testosterone levels increase to about 140 to 200% of baseline.[169][168] Gradually however, the GnRH receptor desensitizes; testosterone levels peak after about 2 to 4 days, return to baseline after about 7 to 8 days, and are reduced to castrate levels within 2 to 4 weeks.[168] Antigonadotropins such as estrogens and cyproterone acetate as well as nonsteroidal antiandrogens such as flutamide and bicalutamide can be used beforehand and concomitantly to reduce or prevent the effects of the testosterone flare caused by GnRH agonists.[170][169][171][172][15][173] In contrast to GnRH agonists, GnRH antagonists, such as degarelix (Firmagon) and elagolix (Orilissa), work by binding to the GnRH receptor without activating it, thereby displacing GnRH from the receptor and preventing its activation.[162] Unlike with GnRH agonists, there is no initial surge effect with GnRH antagonists; the therapeutic effects are immediate, with sex hormone levels being reduced to castrate levels within a few days.[162][163]
GnRH modulators are highly effective for testosterone suppression in transgender women and have few or no side effects when sex hormone deficiency is avoided with concomitant estrogen therapy.[1][174] However, GnRH modulators tend to be very expensive (typically US$10,000 to US$15,000 per year in the United States), and are often denied by medical insurance.[1][175][176][177] GnRH modulator therapy is much less economical than surgical castration, and is less convenient than surgical castration in the long-term as well.[178] Because of their costs, many transgender women cannot afford GnRH modulators and must use other, often less effective options for testosterone suppression.[1][175] GnRH agonists are prescribed as standard practice for transgender women in the United Kingdom however, where the National Health Service (NHS) covers them.[175][179] This is in contrast to the rest of Europe and to the United States.[179] Another drawback of GnRH modulators is that most of them are peptides and are not orally active, requiring administration by injection, implant, or nasal spray.[171] However, non-peptide and orally active GnRH antagonists, elagolix (Orilissa) and relugolix (Relumina), were introduced for medical use in 2018 and 2019, respectively. But they are under patent protection and, as with other GnRH modulators, are very expensive at present.[180]
In adolescents of either sex with relevant indicators, GnRH modulators can be used to stop undesired pubertal changes for a period without inducing any changes toward the sex with which the patient currently identifies. There is considerable controversy over the earliest age at which it is clinically, morally, and legally safe to use GnRH modulators, and for how long. The sixth edition of the World Professional Association for Transgender Health's Standards of Care permit it from Tanner stage 2 but do not allow the addition of hormones until age 16, which could be five or more years later. Sex steroids have important functions in addition to their role in puberty, and some skeletal changes (such as increased height) that may be considered masculine are not hindered by GnRH modulators.
5α-Reductase inhibitors
5α-Reductase inhibitors are inhibitors of the enzyme 5α-reductase, and are a type of specific androgen synthesis inhibitor.[181][182] 5α-Reductase is an enzyme that is responsible for the conversion of testosterone into the more potent androgen dihydrotestosterone (DHT).[181][182] There are three different isoforms of 5α-reductase, types 1, 2, and 3, and these three isoforms show different patterns of expression in the body.[181] Relative to testosterone, DHT is about 2.5- to 10-fold more potent as an agonist of the androgen receptor.[181][182][183] As such, 5α-reductase serves to considerably potentiate the effects of testosterone.[181][182] However, 5α-reductase is expressed only in specific tissues, such as skin, hair follicles, and the prostate gland, and for this reason, conversion of testosterone into DHT happens only in certain parts of the body.[181][182][184] Furthermore, circulating levels of total and free DHT in men are very low at about 1/10th and 1/20th those of testosterone, respectively,[182][185][181] and DHT is efficiently inactivated into weak androgens in various tissues such as muscle, fat, and liver.[181][163][186] As such, it is thought that DHT plays little role as a systemic androgen hormone and serves more as a means of locally potentiating the androgenic effects of testosterone in a tissue-specific manner.[181][187][188] Conversion of testosterone into DHT by 5α-reductase plays an important role in male reproductive system development and maintenance (specifically of the penis, scrotum, prostate gland, and seminal vesicles), male-pattern facial/body hair growth, and scalp hair loss, but has little role in other aspects of masculinization.[181][182][184][189][190] Besides the involvement of 5α-reductase in androgen signaling, it is also required for the conversion of steroid hormones such as progesterone and testosterone into neurosteroids like allopregnanolone and 3α-androstanediol, respectively.[191][192]
5α-Reductase inhibitors include finasteride and dutasteride.[181][182] Finasteride is a selective inhibitor of 5α-reductase types 2 and 3, while dutasteride is an inhibitor of all three isoforms of 5α-reductase.[181][193][194] Finasteride can decrease circulating DHT levels by up to 70%, whereas dutasteride can decrease circulating DHT levels by up to 99%.[193][194] Conversely, 5α-reductase inhibitors do not decrease testosterone levels, and may actually increase them slightly.[1][46][26][195] 5α-Reductase inhibitors are used primarily in the treatment of benign prostatic hyperplasia, a condition in which the prostate gland becomes excessively large due to stimulation by DHT and causes unpleasant urogenital symptoms.[193][196] They are also used in the treatment of androgen-dependent scalp hair loss in men and women.[197][198][199] The medications are able to prevent further scalp hair loss in men and can restore some scalp hair density.[197][198][200] Conversely, the effectiveness of 5α-reductase inhibitors in the treatment of scalp hair loss in women is less clear.[199][182] This may be because androgen levels are much lower in women, in whom they may not play as important of a role in scalp hair loss.[199][182] 5α-Reductase inhibitors are also used to treat hirsutism (excessive body/facial hair growth) in women, and are very effective for this indication.[201] Dutasteride has been found to be significantly more effective than finasteride in the treatment of scalp hair loss in men, which has been attributed to its more complete inhibition of 5α-reductase and by extension decrease in DHT production.[202][203][137] In addition to their antiandrogenic uses, 5α-reductase inhibitors have been found to reduce adverse affective symptoms in premenstrual dysphoric disorder in women.[204][205] This is thought to be due to prevention by 5α-reductase inhibitors of the conversion of progesterone into allopregnanolone during the luteal phase of the menstrual cycle.[204][205]
5α-Reductase inhibitors are sometimes used as a component of feminizing hormone therapy for transgender women in combination with estrogens and/or other antiandrogens.[4][206][61] They may have beneficial effects limited to improvement of scalp hair loss, body hair growth, and possibly skin symptoms such as acne.[24][2][37][61] However, little clinical research on 5α-reductase inhibitors in transgender women has been conducted, and evidence of their efficacy and safety in this group is limited.[206][30] Moreover, 5α-reductase inhibitors have only mild and specific antiandrogenic activity, and are not recommended as general antiandrogens.[30]
5α-Reductase inhibitors have minimal side effects and are well tolerated in both men and women.[207][208] In men, the most common side effect is sexual dysfunction (0.9–15.8% incidence), which may include decreased libido, erectile dysfunction, and reduced ejaculate.[207][208][209][210][211] Another side effect in men is breast changes, such as breast tenderness and gynecomastia (2.8% incidence).[208] Due to decreased levels of androgens and/or neurosteroids, 5α-reductase inhibitors may slightly increase the risk of depression (~2.0% incidence).[210][212][213][207][210][192] There are reports that a small percentage of men may experience persistent sexual dysfunction and adverse mood changes even after discontinuation of 5α-reductase inhibitors.[211][214][212][215][210][209][192] Some of the possible side effects of 5α-reductase inhibitors in men, such as gynecomastia and sexual dysfunction, are actually welcome changes for many transgender women.[16] In any case, caution may be warranted in using 5α-reductase inhibitors in transgender women, as this group is already at a high risk for depression and suicidality.[216][26]
Progestogens
Progesterone, a progestogen, is the other of the two major sex hormones in women.[171] It is mainly involved in the regulation of the female reproductive system, the menstrual cycle, pregnancy, and lactation.[171] The non-reproductive effects of progesterone are fairly insignificant.[217] Unlike estrogens, progesterone is not known to be involved in the development of female secondary sexual characteristics, and hence is not believed to contribute to feminization in women.[2][85] One area of particular interest in terms of the effects of progesterone in women is breast development.[218][219][220] Estrogens are responsible for the development of the ductal and connective tissues of the breasts and the deposition of fat into the breasts during puberty in girls.[218][219] Conversely, high levels of progesterone, in conjunction with other hormones such as prolactin, are responsible for the lobuloalveolar maturation of the mammary glands during pregnancy.[218][219] This allows for lactation and breastfeeding after childbirth.[218][219] Although progesterone causes the breasts to change during pregnancy, the breasts undergo involution and revert to their pre-pregnancy composition and size after the cessation of breastfeeding.[218][221][219] Every pregnancy, lobuloalveolar maturation occurs again anew.[218][219]
There are two types of progestogens: progesterone, which is the natural and bioidentical hormone in the body; and progestins, which are synthetic progestogens.[47] There are dozens of clinically used progestins.[47][222][223] Certain progestins, namely cyproterone acetate and medroxyprogesterone acetate and as described previously, are used at high doses as functional antiandrogens due to their antigonadotropic effects to help suppress testosterone levels in transgender women.[84][85] Aside from the specific use of testosterone suppression however, there are no other indications of progestogens in transgender women at present.[2] In relation to this, the use of progestogens in transgender women is controversial, and they are not otherwise routinely prescribed or recommended.[2][5][6][24][30][224] Besides progesterone, cyproterone acetate, and medroxyprogesterone acetate, other progestogens that have been reported to have been used in transgender women include hydroxyprogesterone caproate, dydrogesterone, norethisterone acetate, and drospirenone.[225][226][30][227][5][228] Progestins in general largely have the same progestogenic effects however, and in theory, any progestin could be used in transgender women.[47]
Clinical research on the use of progestogens in transgender women is very limited.[2][220] Some patients and clinicians believe, on the basis of anecdotal and subjective claims, that progestogens may provide benefits such as improved breast and/or nipple development, mood, and libido in transgender women.[4][3][220] There are no clinical studies to support such reports at present.[2][4][220] No clinical study has assessed the use of progesterone in transgender women, and only a couple of studies have compared the use of progestins (specifically cyproterone acetate and medroxyprogesterone acetate) versus the use of no progestogen in transgender women.[220][229][174] These studies, albeit limited in the quality of their findings, reported no benefit of progestogens on breast development in transgender women.[220][174][24] This has also been the case in limited clinical experience.[230] These reports are in accordance with the normal and even above-average breast development in women with complete androgen insensitivity syndrome, who lack progesterone and have no lobuloalveolar development of the mammary glands on histological examination.[69][231] It is noteworthy that epithelial tissue, which makes up lobuloalveolar tissue, normally (outside of pregnancy and lactation) comprises only about 10 to 15% of the tissue of the breasts.[232][233][234][235] Although the influence of progesterone on breast development is uncertain, progesterone is thought to cause reversible breast enlargement during the menstrual cycle due to local fluid retention in the breasts.[236][237] This may give a misleading appearance of breast growth, and might contribute to anecdotal reports of improved breast size and/or shape with progesterone in transgender women.[236][237]
Progestogens have some antiestrogenic effects in the breasts, for instance decreasing expression of the estrogen receptor and increasing expression of estrogen-metabolizing enzymes,[238][239][240][241] and for this reason, have been used to treat breast pain and benign breast disorders.[242][243][244][245] Progesterone levels during female puberty do not normally increase importantly until near the end of puberty in cisgender girls, a point by which most breast development has already been completed.[246] In addition, concern has been expressed that premature exposure to progestogens during the process of breast development is unphysiological and might compromise final breast growth outcome, although this notion presently remains theoretical.[16][220][247] Though the role of progestogens in pubertal breast development is uncertain, progesterone is essential for lobuloalveolar maturation of the mammary glands during pregnancy.[218] Hence, progestogens are required for any transgender woman who wishes to lactate or breastfeed.[42][248][220] A study found full lobuloalveolar maturation of the mammary glands on histological examination in transgender women treated with an estrogen and high-dose cyproterone acetate.[249][250][251] However, lobuloalveolar development reversed with discontinuation of cyproterone acetate, indicating that continued progestogen exposure is necessary to maintain the tissue.[249]
In terms of the effects of progestogens on sex drive, one study assessed the use of dydrogesterone to improve sexual desire in transgender women and found no benefit.[227] Another study likewise found that oral progesterone did not improve sexual function in cisgender women.[252]
Progestogens can have adverse effects.[24][30][47][222][253][49] Oral progesterone has inhibitory neurosteroid effects and can produce side effects such as sedation, mood changes, and alcohol-like effects.[47][254][255] Many progestins have off-target activity, such as androgenic, antiandrogenic, glucocorticoid, and antimineralocorticoid activity, and these activities likewise can contribute unwanted side effects.[47][222] Furthermore, the addition of a progestin to estrogen therapy has been found to increase the risk of blood clots, cardiovascular disease (e.g., coronary heart disease and stroke), and breast cancer compared to estrogen therapy alone in postmenopausal women.[32][30][24][256] Although it is unknown if these health risks of progestins occur in transgender women similarly, it cannot be ruled out that they do.[32][30][24] High-dose progestogens increase the risk of benign brain tumors including prolactinomas and meningiomas as well.[257][258] Because of their potential detrimental effects and lack of supported benefits, some researchers have argued that, aside from the purpose of testosterone suppression, progestogens should not generally be used or advocated in transgender women or should only be used for a limited duration (e.g., 2–3 years).[32][24][5][6][32][224] Conversely, other researchers have argued that the risks of progestogens in transgender women are likely minimal, and that in light of potential albeit hypothetical benefits, should be used if desired.[3] In general, some transgender women respond favorably to the effects of progestogens, while others respond negatively.[3]
Progesterone is most commonly taken orally.[47][256] However, oral progesterone has very low bioavailability, and produces relatively weak progestogenic effects even at high doses.[259][260][256][261][262] In accordance, and in contrast to progestins, oral progesterone has no antigonadotropic effects in men even at high doses.[254][263] Progesterone can also be taken by various parenteral (non-oral) routes, including sublingually, rectally, and by intramuscular or subcutaneous injection.[47][244][264] These routes do not have the bioavailability and efficacy issues of oral progesterone, and accordingly, can produce considerable antigonadotropic and other progestogenic effects.[47][261][265] Transdermal progesterone is poorly effective, owing to absorption issues.[47][244][262] Progestins are usually taken orally.[47] In contrast to progesterone, most progestins have high oral bioavailability, and can produce full progestogenic effects with oral administration.[47] Some progestins, such as medroxyprogesterone acetate and hydroxyprogesterone caproate, are or can be used by intramuscular or subcutaneous injection instead.[266][244] Almost all progestins, with the exception of dydrogesterone, have antigonadotropic effects.[47]
Miscellaneous
Galactogogues such as the peripherally selective D2 receptor antagonist and prolactin releaser domperidone can be used to induce lactation in transgender women who wish to breastfeed.[267][268][42] An extended period of combined estrogen and progestogen therapy is necessary to mature the lobuloalveolar tissue of the breasts before this can be successful.[248][42][269][249] There are several published reports of lactation and/or breastfeeding in transgender women.[270][271][248][269][42][272][273]
Interactions
Many of the medications used in feminizing hormone therapy, such as estradiol, cyproterone acetate, and bicalutamide, are substrates of CYP3A4 and other cytochrome P450 enzymes. As a result, inducers of CYP3A4 and other cytochrome P450 enzymes, such as carbamazepine, phenobarbital, phenytoin, rifampin, rifampicin, and St. John's wort, among others, may decrease circulating levels of these medications and thereby decrease their effects. Conversely, inhibitors of CYP3A4 and other cytochrome P450 enzymes, such as cimetidine, clotrimazole, grapefruit juice, itraconazole, ketoconazole, and ritonavir, among others, may increase circulating levels of these medications and thereby increase their effects. The concomitant use of a cytochrome P450 inducer or inhibitor with feminizing hormone therapy may necessitate medication dosage adjustments.
Effects
Effect | Time to expected onset of effect[a] |
Time to expected maximum effect[a][b] |
Permanency if hormone therapy is stopped |
---|---|---|---|
Breast development and nipple/areolar enlargement | 2–6 months | 1–3 years | Permanent |
Thinning/slowed growth of facial/body hair | 4–12 months | >3 years[c] | Reversible |
Cessation/reversal of male-pattern scalp hair loss | 1–3 months | 1–2 years[d] | Reversible |
Softening of skin/decreased oiliness and acne | 3–6 months | Unknown | Reversible |
Redistribution of body fat in a feminine pattern | 3–6 months | 2–5 years | Reversible |
Decreased muscle mass/strength | 3–6 months | 1–2 years[e] | Reversible |
Widening and rounding of the pelvis[f] | Unspecified | Unspecified | Permanent |
Changes in mood, emotionality, and behavior | Unspecified | Unspecified | Reversible |
Decreased sex drive | 1–3 months | 3–6 months | Reversible |
Decreased spontaneous/morning erections | 1–3 months | 3–6 months | Reversible |
Erectile dysfunction and decreased ejaculate volume | 1–3 months | Variable | Reversible |
Decreased sperm production/fertility | Unknown | >3 years | Reversible or permanent[g] |
Decreased testicle size | 3–6 months | 2–3 years | Unknown |
Decreased penis size | None[h] | Not applicable | Not applicable |
Decreased prostate gland size | Unspecified | Unspecified | Unspecified |
Voice changes | None[i] | Not applicable | Not applicable |
Footnotes and sources
Footnotes:
|
The spectrum of effects of hormone therapy in transgender women depend on the specific medications and dosages used. In any case, the main effects of hormone therapy in transgender women are feminization and demasculinization, and are as follows:
Physical changes
Breast development
![](http://upload.wikimedia.org/wikipedia/commons/thumb/b/b3/Transgender_woman_breast.png/230px-Transgender_woman_breast.png)
Breast, nipple, and areolar development varies considerably depending on genetics, body composition, age of HRT initiation, and many other factors. Development can take a couple years to nearly a decade for some. However, many transgender women report there is often a "stall" in breast growth during transition, or significant breast asymmetry. Transgender women on HRT often experience less breast development than cisgender women (especially if started after young adulthood). For this reason, many seek breast augmentation. Transgender patients opting for breast reduction are rare. Shoulder width and the size of the rib cage also play a role in the perceivable size of the breasts; both are usually larger in transgender women, causing the breasts to appear proportionally smaller. Thus, when a transgender woman opts to have breast augmentation, the implants used tend to be larger than those used by cisgender women.[283]
In clinical trials, cisgender women have used stem cells from fat to regrow their breasts after mastectomies. This could some day eliminate the need for implants for transgender women.[284]
In transgender women on HRT, as in cisgender women during puberty, breast ducts and Cooper's ligaments develop under the influence of estrogen. Progesterone causes the milk sacs (mammary alveoli) to develop, and with the right stimuli, a transgender woman may lactate. Additionally, HRT often makes the nipples more sensitive to stimulation.
Breast development in transgender women begins within 2 to 3 months of the start of hormone therapy and continues for up to 2 years.[285][37] Breast development seems to be better in transgender women who have a higher body mass index.[285][37] As a result, it may be beneficial to breast development for thin transgender women to gain some weight in the early phases of hormone therapy.[285][37] Different estrogens, such as estradiol valerate, conjugated estrogens, and ethinylestradiol, appear to produce equivalent results in terms of breast sizes in transgender women.[285][229][174] The sudden discontinuation of estrogen therapy has been associated with onset of galactorrhea (lactation).[285][37]
Skin changes
The uppermost layer of skin, the stratum corneum, becomes thinner and more translucent. Spider veins may appear or be more noticeable as a result. Collagen decreases, and tactile sensation increases. The skin becomes softer,[286] more susceptible to tearing and irritation from scratching or shaving, and slightly lighter in color because of a slight decrease in melanin.
Sebaceous gland activity (which is triggered by androgens) lessens, reducing oil production on the skin and scalp. Consequently, the skin becomes less prone to acne. It also becomes drier, and lotions or oils may be necessary.[283][287] The pores become smaller because of the lower quantities of oil being produced. Many apocrine glands – a type of sweat gland – become inactive, and body odor decreases. Remaining body odor becomes less metallic, sharp, or acrid, and more sweet and musky.[citation needed]
As subcutaneous fat accumulates,[283] dimpling, or cellulite, becomes more apparent on the thighs and buttocks. Stretch marks (striae distensae) may appear on the skin in these areas. Susceptibility to sunburn increases, possibly because the skin is thinner and less pigmented.[citation needed]
Hair changes
Antiandrogens affect existing facial hair only slightly; patients may see slower growth and some reduction in density and coverage.[288] Those who are less than a decade past puberty and/or lack a significant amount of facial hair may have better results. Patients taking antiandrogens tend to have better results with electrolysis and laser hair removal than those who are not.[citation needed] In patients in their teens or early twenties, antiandrogens prevent new facial hair from developing if testosterone levels are within the normal female range.[283][287]
Body hair (on the chest, shoulders, back, abdomen, buttocks, thighs, tops of hands, and tops of feet) turns, over time, from terminal ("normal") hairs to tiny, blonde vellus hairs. Arm, perianal, and perineal hair is reduced but may not turn to vellus hair on the latter two regions (some cisgender women also have hair in these areas). Underarm hair changes slightly in texture and length, and pubic hair becomes more typically female in pattern. Lower leg hair becomes less dense. All of these changes depend to some degree on genetics.[283][287]
Head hair may change slightly in texture, curl, and color. This is especially likely with hair growth from previously bald areas.[citation needed] Eyebrows do not change because they are not androgenic hair.[289]
Eye changes
The lens of the eye changes in curvature.[290][291][292][286] Because of decreased androgen levels, the meibomian glands (the sebaceous glands on the upper and lower eyelids that open up at the edges) produce less oil. Because oil prevents the tear film from evaporating, this change may cause dry eyes.[293][294][295][296][297]
Fat changes
The distribution of adipose (fat) tissue changes slowly over months and years. HRT causes the body to accumulate new fat in a typically feminine pattern, including in the hips, thighs, buttocks, pubis, upper arms, and breasts. (Fat on the hips, thighs, and buttocks has a higher concentration of omega-3 fatty acids and is meant to be used for lactation.) The body begins to burn old adipose tissue in the waist, shoulders, and back, making those areas smaller.[283]
Subcutaneous fat increases in the cheeks and lips, making the face appear rounder, with slightly less emphasis on the jaw as the lower portion of the cheeks fills in.
Bone/skeletal changes
Male-to-female hormone therapy causes the hips to rotate slightly forward because of changes in the tendons. Hip discomfort is common. This can cause a reduction in total body height.
If estrogen therapy is begun prior to pelvis ossification, which occurs around the age of 25, the pelvic outlet and inlet open slightly. The femora also widen, because they are connected to the pelvis. The pelvis retains some masculine characteristics, but the end result of HRT is wider hips than a cisgender man and closer to those of a cisgender woman.[citation needed]
Unaffected characteristics
HRT does not reverse bone changes that have already been established by puberty. Consequently, it does not affect height except for the aforementioned reasons; the length of the arms, legs, hands, and feet; or the width of the shoulders and rib cage. However, details of bone shape change throughout life, with bones becoming heavier and more deeply sculptured under the influence of androgens, and HRT does prevent such changes from progressing further.
The width of the hips is not affected in individuals for whom epiphyseal closure (fusion and closure of the ends of bones, which prevents any further lengthening) has taken place. This occurs in most people between 18 and 25 years of age. [citation needed] Already-established changes to the shape of the hips cannot be reversed by HRT whether epiphyseal closure has taken place or not.[citation needed]
Established changes to the bone structure of the face are also unaffected by HRT. A significant majority of craniofacial changes occur during adolescence. Post-adolescent growth is considerably slower and minimal by comparison.[298] Also unaffected is the prominence of the thyroid cartilage (Adam's apple). These changes may be reversed by surgery (facial feminization surgery and tracheal shave, respectively).
During puberty, the voice deepens in pitch and becomes more resonant. These changes are permanent and are not affected by HRT. Voice therapy and/or surgery may be used instead to achieve a more female-sounding voice.
Facial hair develops during puberty and is only slightly affected by HRT. It may, however, be eliminated nearly permanently with laser hair removal, or permanently with electrolysis.[citation needed]
Mental changes
The psychological effects of feminizing hormone therapy are harder to define than physical changes. Because hormone therapy is usually the first physical step taken to transition, the act of beginning it has a significant psychological effect, which is difficult to distinguish from hormonally induced changes.
Mood changes
Changes in mood and well-being occur with hormone therapy in transgender women.[299]
Sexual changes
Some transgender women report a significant reduction in libido, depending on the dosage of antiandrogens.[300] A small number of post-operative transgender women take low doses of testosterone to boost their libido. Many pre-operative transgender women wait until after reassignment surgery to begin an active sex life. Raising the dosage of estrogen or adding a progestogen raises the libido of some transgender women.[citation needed]
Spontaneous and morning erections decrease significantly in frequency, although some patients who have had an orchiectomy still experience morning erections. Voluntary erections may or may not be possible, depending on the amount of hormones and/or antiandrogens being taken.[citation needed]
Managing long-term hormonal regimens have not been studied and are difficult to estimate because research on the long-term use of hormonal therapy has not been noted.[32] However, it is possible to speculate the outcomes of these therapies on transgender people based on the knowledge of the current effects of gonadal hormones on sexual functioning in cisgender men and women.[301]
Firstly, if one is to decrease testosterone in male-to-female gender transition, it is likely that sexual desire and arousal would be inhibited; alternatively, if high doses of estrogen negatively impact sexual desire, which has been found in some research with cisgender women, it is hypothesized that combining androgens with high levels of estrogen would intensify this outcome.[301] Unfortunately, to date there haven't been any randomized clinical trials looking at the relationship between type and dose of transgender hormone therapy, so the relationship between them remains unclear.[301] Typically, the estrogens given for male-to-female gender transition are 2 to 3 times higher than the recommended dose for HRT in postmenopausal women.[32] Pharmacokinetic studies indicate taking these increased doses may lead to a higher boost in plasma estradiol levels; however, the long-term side effects haven't been studied and the safety of this route is unclear.[32]
As with any pharmacological or hormone therapy, there are potential side effects, which in the case of transgender hormone therapy include changes in sexual functioning. These have the ability to significantly impact sexual functioning, either directly or indirectly through the various side effects, such as cerebrovascular disorders, obesity, and mood fluctuations.[301] In addition, some research has found an onset of diabetes following feminizing hormone therapy, which impairs sexual response.[citation needed] Whatever route an individual and their doctor choose to take, it is important to consider both the medical risks of hormone therapy as well as the psychological needs of the patient.
Brain changes
Several studies have found that hormone therapy in transgender women causes the structure of the brain to change in the direction of female proportions.[302][303][304][305][306] In addition, studies have found that hormone therapy in transgender women causes performance in cognitive tasks, including visuospatial, verbal memory, and verbal fluency, to shift in a more female direction.[302][299]
Health changes
A number of health changes and adverse effects can occur with feminizing hormone therapy.[citation needed]
A 2015 review concluded that hormone therapy for transgender people is safe when supervised by a qualified medical professional.[307]
Cardiovascular changes
The most significant cardiovascular risk for transgender women is the prothrombotic effect (increased blood clotting) of estrogens. This manifests most significantly as an increased risk for venous thromboembolism (VTE): deep vein thrombosis (DVT) and pulmonary embolism (PE), which occurs when blood clots from DVT break off and migrate to the lungs. Symptoms of DVT include pain or swelling of one leg, especially the calf. Symptoms of PE include chest pain, shortness of breath, fainting, and heart palpitations, sometimes without leg pain or swelling.
VTE occurs more frequently in the first year of treatment with estrogens. The risk of VTE is higher with oral non-bioidentical estrogens such as ethinylestradiol and conjugated estrogens than with parenteral formulations of estradiol such as injectable, transdermal, implantable, and intranasal.[308][309][310][311][312][313][314][315][316][317][318][161][319][320][321][322][323][53][324][325][326][327] VTE risk also increases with age and in patients who smoke, so many clinicians advise using the safer estrogen formulations in smokers and patients older than 40. In addition, VTE risk is increased by progestins and increases with the dosages of both estrogens and progestins. Obesity increases the risk of VTE as well. Increased risk of VTE with estrogens is thought to be due to their influence on liver protein synthesis, specifically on the production of coagulation factors.[47] Non-bioidentical estrogens such as conjugated estrogens and especially ethinylestradiol have markedly disproportionate effects on liver protein synthesis relative to estradiol.[47] In addition, oral estradiol has a 4- to 5-fold increased impact on liver protein synthesis than does transdermal estradiol and other parenteral estradiol routes.[47][328]
Because the risks of warfarin – which is used to treat blood clots – in a relatively young and otherwise healthy population are low, while the risk of adverse physical and psychological outcomes for untreated transgender patients is high, prothrombotic mutations (such as factor V Leiden, antithrombin III, and protein C or S deficiency) are not absolute contraindications for hormonal therapy.[37]
A 2018 cohort study of 2842 transfeminine individuals in the United States treated with a mean follow-up of 4.0 years observed an increased risk of VTE, stroke, and heart attack relative to a cisgender reference population.[329][330][16][52] The estrogens used included oral estradiol (1 to 10 mg/day) and other estrogen formulations.[52] Other medications such as antiandrogens like spironolactone were also used.[52]
A 2019 systematic review and meta-analysis found an incidence rate of VTE of 2.3 per 1000 person-years with feminizing hormone therapy in transgender women.[331] For comparison, the rate in the general population has been found to be 1.0–1.8 per 1000 person-years, and the rate in premenopausal women taking birth control pills has been found to be 3.5 per 1000 patient-years.[331][332] There was significant heterogeneity in the rates of VTE across the included studied, and the meta-analysis was unable to perform subgroup analyses between estrogen type, estrogen route, estrogen dosage, concomitant antiandrogen or progestogen use, or patient characteristics (e.g., sex, age, smoking status, weight) corresponding to known risk factors for VTE.[331] Due to the inclusion of some studies using ethinylestradiol, which is more thrombotic and is no longer used in transgender women, the researchers noted that the VTE risk found in their study may be an overestimate.[331]
In a 2016 study that specifically assessed oral estradiol, the incidence of VTE in 676 transgender women who were treated for an average of 1.9 years each was only one individual, or 0.15% of the group, with an incidence of 7.8 events per 10,000 person-years.[333][334] The dosage of oral estradiol used was 2 to 8 mg/day.[334] Almost all of the transgender women were also taking spironolactone (94%), a subset were also taking finasteride (17%), and fewer than 5% were also taking a progestogen (usually oral progesterone).[334] The findings of this study suggest that the incidence of VTE is low in transgender women taking oral estradiol.[333][334]
Cardiovascular health in transgender women has been reviewed in recent publications.[335][51]
Gastrointestinal changes
Estrogens may increase the risk of gallbladder disease, especially in older and obese people.[286] They may also increase transaminase levels, indicating liver toxicity, especially when taken in oral form.[citation needed]
Metabolic changes
A patient's metabolic rate may change, causing an increase or decrease in weight and energy levels, changes to sleep patterns, and temperature sensitivity.[citation needed] Androgen deprivation leads to slower metabolism and a loss of muscle tone. Building muscle takes more work. The addition of a progestogen may increase energy, although it may increase appetite as well.[citation needed]
Bone changes
Both estrogens and androgens are necessary in all humans for bone health. Young, healthy women produce about 10 mg of testosterone monthly,[citation needed] and higher bone mineral density in males is associated with higher serum estrogen. Both estrogen and testosterone help to stimulate bone formation, especially during puberty. Estrogen is the predominant sex hormone that slows bone loss, even in men.
Cancer risk
Studies are mixed on whether the risk of breast cancer is increased with hormone therapy in transgender women.[336][337][338][339] Two cohort studies found no increase in risk relative to cisgender men,[337][338] whereas another cohort study found an almost 50-fold increase in risk such that the incidence of breast cancer was between that of cisgender men and cisgender women.[339][336] There is no evidence that breast cancer risk in transgender women is greater than in cisgender women.[340] Twenty cases of breast cancer in transgender women have been reported as of 2019.[336][341]
Cisgender men with gynecomastia have not been found to have an increased risk of breast cancer.[342] It has been suggested that a 46,XY karyotype (one X chromosome and one Y chromosome) may be protective against breast cancer compared to having a 46,XX karyotype (two X chromosomes).[342] Men with Klinefelter's syndrome (47,XXY karyotype), which causes hypoandrogenism, hyperestrogenism, and a very high incidence of gynecomastia (80%), have a dramatically (20- to 58-fold) increased risk of breast cancer compared to karyotypical men (46,XY), closer to the rate of karyotypical women (46,XX).[342][343][344] The incidences of breast cancer in karyotypical men, men with Klinefelter's syndrome, and karyotypical women are approximately 0.1%,[345] 3%,[343] and 12.5%,[346] respectively. Women with complete androgen insensitivity syndrome (46,XY karyotype) never develop male sex characteristics and have normal and complete female morphology, including breast development,[347] yet have not been reported to develop breast cancer.[67][348] The risk of breast cancer in women with Turner syndrome (45,XO karyotype) also appears to be significantly decreased, though this could be related to ovarian failure and hypogonadism rather necessarily than to genetics.[349]
Prostate cancer is extremely rare in gonadectomized transgender women who have been treated with estrogens for a prolonged period of time.[1][350][351] Whereas as many as 70% of men show prostate cancer by their 80s,[149] only a handful of cases of prostate cancer in transgender women have been reported in the literature.[1][350][351] As such, and in accordance with the fact that androgens are responsible for the development of prostate cancer, HRT appears to be highly protective against prostate cancer in transgender women.[1][350][351]
The risks of certain types of benign brain tumors including meningioma and prolactinoma are increased with hormone therapy in transgender women.[352] These risks have mostly been associated with the use of cyproterone acetate.[352]
Other changes
Estrogens and progestogens can cause prolactinomas, which are prolactin-secreting tumors of the pituitary gland. Milk discharge from the nipples can be a sign of elevated prolactin levels. If a prolactinoma becomes large enough, it can cause visual changes (especially decreased peripheral vision), headaches, depression or other mood changes, dizziness, nausea, vomiting, and symptoms of pituitary failure, like hypothyroidism.
Monitoring
Especially in the early stages of feminizing hormone therapy, blood work is done frequently to assess hormone levels and liver function. The Endocrine Society recommends that patients have blood tests every three months in the first year of HRT for estradiol and testosterone, and that spironolactone, if used, be monitored every 2 to 3 months in the first year.[1] Recommended ranges for total estradiol and total testosterone levels include but are not limited to the following:
Source | Place | Estradiol, total | Testosterone, total | |
---|---|---|---|---|
Endocrine Society | United States | 100–200 pg/mL | <50 ng/dL | |
World Professional Association for Transgender Health (WPATH) | United States | "[T]estosterone levels [...] below the upper limit of the normal female range and estradiol levels within a premenopausal female range but well below supraphysiologic levels." "[M]aintain levels within physiologic ranges for a patient's desired gender expression (based on goals of full feminization/masculinization)." | ||
Center of Excellence for Transgender Health (UCSF ) | United States | "The interpretation of hormone levels for transgender individuals is not yet evidence based; physiologic hormone levels in non-transgender people are used as reference ranges." "Providers are encouraged to consult with their local lab(s) to obtain hormone level reference ranges for both 'male' and 'female' norms, [which can vary,] and then apply the correct range when interpreting results based on the current hormonal sex, rather than the sex of registration." | ||
Fenway Health | United States | 100–200 pg/mL | <55 ng/dL | |
Callen-Lorde | United States | "Some guidelines recommend checking estradiol and testosterone levels at baseline and throughout the monitoring of estrogen therapy. We have not found a clinical use for routine hormone levels that justifies the expense. However, we recognize that individual providers may adjust their prescribing and monitoring practices as needed to comply with guidelines or when guided by patient need." | ||
International Planned Parenthood Federation (IPPF) | United Kingdom | <200 pg/mL | 30–100 ng/dL | |
National Health Service (NHS) Foundation Trusts | United Kingdom | 55–160 pg/mL | 30–85 ng/dL | |
Royal College of Psychiatry (RCP) | United Kingdom | 80–140 pg/mL | "Well below normal male range" | |
Vancouver Coastal Health (VCH) | Canada | ND | <1.5 nmol/L | |
Sources: See template. |
The optimal ranges for estrogen apply only to individuals taking estradiol (or an ester of estradiol), and not to those taking synthetic or other non-bioidentical preparations (e.g., conjugated estrogens or ethinylestradiol).[1]
Physicians also recommend broader medical monitoring, including complete blood counts; tests of renal function, liver function, and lipid and glucose metabolism; and monitoring of prolactin levels, body weight, and blood pressure.[1][353]
If prolactin levels are greater than 100 ng/mL, estrogen therapy should be stopped and prolactin levels should be rechecked after 6 to 8 weeks.[353] If prolactin levels remain high, an MRI scan of the pituitary gland to check for the presence of a prolactinoma should be ordered.[353] Otherwise, estrogen therapy may be restarted at a lower dosage.[353] Cyproterone acetate is particularly associated with elevated prolactin levels, and discontinuation of cyproterone acetate lowers prolactin levels.[354][355][356] In contrast to cyproterone acetate, estrogen and spironolactone therapy is not associated with increased prolactin levels.[356][357]
History
Effective pharmaceutical female sex-hormonal medications first became available in the 1920s and 1930s.[358] One of the earliest reports of hormone therapy in transgender women was published by Danish endocrinologist Christian Hamburger in 1953.[359] One of his patients was Christine Jorgensen, who he had treated starting in 1950.[360][361][362][363] Additional reports of hormone therapy in transgender women were published by Hamburger, the German-American endocrinologist Harry Benjamin, and other researchers in the mid-to-late 1960s.[364][365][366][367][368][369] However, Benjamin had several hundred transgender patients under his care by the late 1950s,[85] and had treated transgender women with hormone therapy as early as the late 1940s or early 1950s.[370][371][372][360] In any case, Hamburger is said to be the first to treat transgender women with hormone therapy.[373]
One of the first transgender clinics was opened in the mid-1960s at the Johns Hopkins School of Medicine.[374][85] By 1981, there were almost 40 such centers.[375] A review of the hormonal regimens of 20 of the centers was published that year.[364][375] The Harry Benjamin International Gender Dysphoria Association (HBIGDA), now known as the World Professional Association for Transgender Health (WPATH), was formed in 1979, with the first version of the Standards of Care published the same year.[360] The Endocrine Society published guidelines for the hormonal care of transgender people in 2009, with a revised version in 2017.[364][376][1]
Hormone therapy for transgender women was initially done using high-dose estrogen therapy with parenteral estrogens such as estradiol benzoate, estradiol valerate, and estradiol undecylate and with oral estrogens such as ethinylestradiol, conjugated estrogens, and diethylstilbestrol.[367][368][369][375] Progestogens, such as hydroxyprogesterone caproate and medroxyprogesterone acetate, were also sometimes included.[359][367][368][375][377][36][378] The antiandrogen and progestogen cyproterone acetate was first used in transgender women by 1977.[379][380] Spironolactone, another antiandrogen, was first used in transgender women by 1986.[381][377][278][382] Antiandrogens were well-established in hormone therapy for transgender women by the early 1990s.[36] Estrogen doses in transgender women were reduced following the introduction of antiandrogens.[citation needed] Ethinylestradiol, conjugated estrogens, and other non-bioidentical estrogens stopped being used in transgender women in favor of estradiol starting around 2000 due to their greater risks of blood clots and cardiovascular issues.[279][335][331]
See also
References
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suggested) (help) - ^ A. Hughes; S. H. Hasan; G. W. Oertel; H. E. Voss, F. Bahner, F. Neumann, H. Steinbeck, K.-J. Gräf, J. Brotherton, H. J. Horn, R. K. Wagner (27 November 2013). Androgens II and Antiandrogens / Androgene II und Antiandrogene. Springer Science & Business Media. pp. 490–491. ISBN 978-3-642-80859-3.
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[Megestrol acetate] produces a transient reduction in plasma testosterone to levels somewhat higher than those in castrated men. When used in a dose of 40 mg tid, in combination with estradiol 0.5–1.5 mg/d, it acts synergistically to suppress pituitary gonadotropins and maintain plasma testosterone at castration levels for periods up to one year.
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Non-steroidal antiandrogens include flutamide, nilutamide, and bicalutamide, which do not lower androgen levels and may be favorable for individuals who want to preserve sex drive and fertility [9].
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Traditionally, patients have been advised to cryopreserve sperm prior to starting cross-sex hormone therapy as there is a potential for a decline in sperm motility with high-dose estrogen therapy over time (Lubbert et al., 1992). However, this decline in fertility due to estrogen therapy is controversial due to limited studies.
{{cite journal}}
: Unknown parameter|name-list-format=
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Estrogens are highly efficient inhibitors of the hypothalamic-hypophyseal-testicular axis (212–214). Aside from their negative feedback action at the level of the hypothalamus and pituitary, direct inhibitory effects on the testis are likely (215,216). [...] The histology of the testes [with estrogen treatment] showed disorganization of the seminiferous tubules, vacuolization and absence of lumen, and compartmentalization of spermatogenesis.
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Estrogens act primarily through negative feedback at the hypothalamic-pituitary level to reduce LH secretion and testicular androgen synthesis. [...] Interestingly, if the treatment with estrogens is discontinued after 3 yr. of uninterrupted exposure, serum testosterone may remain at castration levels for up to another 3 yr. This prolonged suppression is thought to result from a direct effect of estrogens on the Leydig cells.
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[...] estrogen or antiandrogen treatment prior to the first leuprolide injection may reduce [the risk of symptoms caused by the testosterone "flare" at the initiation of treatment] (16).
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Therapy with GnRH analogs is expensive and requires intramuscular injections of depot formulations, the insert of a subcutaneous implant yearly, or, much less commonly, daily subcutaneous injections.
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Treatment is expensive, with costs typically in the range of $10,000–$15,000 per year.
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[...] caution is recommended while prescribing oral finasteride to male-to-female transsexuals, as the drug has been associated with inducing depression, anxiety and suicidal ideation, symptoms that are particularly common in patients with gender dysphoria, who are already at a high risk.[9]
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: CS1 maint: unflagged free DOI (link) - ^ a b Meyer WJ, Webb A, Stuart CA, Finkelstein JW, Lawrence B, Walker PA (April 1986). "Physical and hormonal evaluation of transsexual patients: a longitudinal study". Archives of Sexual Behavior. 15 (2): 121–38. doi:10.1007/bf01542220. PMID 3013122. S2CID 42786642.
- ^ Daniel R. Mishell; Val Davajan (1979). Reproductive endocrinology, infertility, and contraception. F. A. Davis Co. p. 224. ISBN 978-0-8036-6235-3.
It has been suggested that progestins be added during the last week of each cycle of estrogen therapy in order to develop more rounded breasts rather than the conical breasts many of these patients develop, but we have been unable to detect any difference in breast contour with or without progestins.
- ^ Morris JM (June 1953). "The syndrome of testicular feminization in male pseudohermaphrodites". Am. J. Obstet. Gynecol. 65 (6): 1192–1211. doi:10.1016/0002-9378(53)90359-7. PMID 13057950.
- ^ Lorincz AM, Sukumar S (2006). "Molecular links between obesity and breast cancer". Endocrine-Related Cancer. 13 (2): 279–92. doi:10.1677/erc.1.00729. PMID 16728564.
Adipocytes make up the bulk of the human breast, with epithelial cells accounting for only approximately 10% of human breast volume.
- ^ Howard BA, Gusterson BA (2000). "Human breast development". Journal of Mammary Gland Biology and Neoplasia. 5 (2): 119–37. doi:10.1023/A:1026487120779. PMID 11149569. S2CID 10819224.
In the stroma, there is an increase in the amount of fibrous and fatty tissue, with the adult nonlactating breast consisting of 80% or more of stroma.
- ^ Sperling, Mark A. (10 April 2014). Pediatric Endocrinology. Elsevier Health Sciences. pp. 598–. ISBN 978-1-4557-5973-6.
Estrogen stimulates the nipples to grow, mammary terminal duct branching to progress to the stage at which ductules are formed, and fatty stromal growth to increase until it constitutes about 85% of the mass of the breast. [...] Lobulation appears around menarche, when multiple blind saccular buds form by branching of the terminal ducts. These effects are due to the presence of progesterone. [...] Full alveolar development normally only occurs during pregnancy under the influence of additional progesterone and prolactin.
{{cite book}}
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suggested) (help) - ^ Hagisawa S, Shimura N, Arisaka O (2012). "Effect of excess estrogen on breast and external genitalia development in growth hormone deficiency". Journal of Pediatric and Adolescent Gynecology. 25 (3): e61–3. doi:10.1016/j.jpag.2011.11.005. PMID 22206682.
Estrogen stimulates growth of the nipples, progression of mammary duct branching to the stage at which ductiles are formed, and fatty stromal growth until it constitutes about 85% of the mass of the breast.
- ^ a b Lee-Ellen C. Copstead-Kirkhorn; Jacquelyn L. Banasik (25 June 2014). Pathophysiology - E-Book. Elsevier Health Sciences. pp. 660–. ISBN 978-0-323-29317-4.
Throughout the reproductive years, some women note swelling of the breast around the latter part of each menstrual cycle before the onset of menstruation. The water retention and subsequent swelling of breast tissue during this phase of the menstrual cycle are thought to be due to high levels of circulating progesterone stimulating the secretory cells of the breast.12
- ^ a b Farage MA, Neill S, MacLean AB (2009). "Physiological changes associated with the menstrual cycle: a review". Obstet Gynecol Surv. 64 (1): 58–72. doi:10.1097/OGX.0b013e3181932a37. PMID 19099613. S2CID 22293838.
- ^ Gompel A (April 2012). "Micronized progesterone and its impact on the endometrium and breast vs. progestogens". Climacteric. 15 Suppl 1: 18–25. doi:10.3109/13697137.2012.669584. PMID 22432812. S2CID 17700754.
- ^ Cline JM, Wood CE (December 2008). "The Mammary Glands of Macaques". Toxicol Pathol. 36 (7): 134s–141s. doi:10.1177/0192623308327411. PMC 3070964. PMID 21475638.
- ^ Pasqualini JR (2007). "Progestins and breast cancer". Gynecol. Endocrinol. 23 Suppl 1: 32–41. doi:10.1080/09513590701585003. PMID 17943537. S2CID 46634314.
- ^ Pasqualini JR (2009). "Breast cancer and steroid metabolizing enzymes: the role of progestogens". Maturitas. 65 Suppl 1: S17–21. doi:10.1016/j.maturitas.2009.11.006. PMID 19962254.
- ^ Schindler AE (February 2011). "Dydrogesterone and other progestins in benign breast disease: an overview". Arch. Gynecol. Obstet. 283 (2): 369–71. doi:10.1007/s00404-010-1456-7. PMID 20383772. S2CID 9125889.
- ^ Winkler UH, Schindler AE, Brinkmann US, Ebert C, Oberhoff C (December 2001). "Cyclic progestin therapy for the management of mastopathy and mastodynia". Gynecol. Endocrinol. 15 Suppl 6: 37–43. doi:10.1080/gye.15.s6.37.43. PMID 12227885. S2CID 27589741.
- ^ a b c d Ruan X, Mueck AO (November 2014). "Systemic progesterone therapy--oral, vaginal, injections and even transdermal?". Maturitas. 79 (3): 248–55. doi:10.1016/j.maturitas.2014.07.009. PMID 25113944.
- ^ Bińkowska, Małgorzata; Woroń, Jarosław (2015). "Progestogens in menopausal hormone therapy". Menopausal Review. 14 (2): 134–143. doi:10.5114/pm.2015.52154. ISSN 1643-8876. PMC 4498031. PMID 26327902.
- ^ Kenneth L. Becker (2001). Principles and Practice of Endocrinology and Metabolism. Lippincott Williams & Wilkins. pp. 889–. ISBN 978-0-7817-1750-2.
- ^ Sanjay Rajagopalan; Debabrata Mukherjee; Emile R. Mohler (2005). Manual of Vascular Diseases. Lippincott Williams & Wilkins. pp. 1–. ISBN 978-0-7817-4499-7.
- ^ a b c Foss GL (March 1958). "Disturbances of lactation". Clin Obstet Gynecol. 1 (1): 245–54. doi:10.1097/00003081-195803000-00021. PMID 13573669. S2CID 42825519.
Experimentally I have been able to induce lactogenesis in a male transvestite whose testes had been removed some years before and whose breasts had been well developed over a long period with stilbestrol and ethisterone.9 In July, 1955, 600 mg. of estradiol was implanted subcutaneously and weekly injections of 50 mg. of progesterone were given for four months. For the next month daily injections of 10 mg. estradiol dipropionate and 50 mg. progesterone were given. These injections were continued for another month, increasing progesterone to 100 mg. daily. Both hormones were then withdrawn, and daily injections of increasing doses of prolactin and somatotropin were given for four days; at the same time, the patient used a breast bump four times daily for 5 minutes on both sides. During this time the mammary veins were visibly enlarged and on the sixth and seventh days 1 to 2 cc. of milky fluid was collected.
- ^ a b c Kanhai RC, Hage JJ, van Diest PJ, Bloemena E, Mulder JW (January 2000). "Short-term and long-term histologic effects of castration and estrogen treatment on breast tissue of 14 male-to-female transsexuals in comparison with two chemically castrated men". The American Journal of Surgical Pathology. 24 (1): 74–80. doi:10.1097/00000478-200001000-00009. PMID 10632490.
- ^ Lawrence, Anne A. (2007). "Transgender Health Concerns". The Health of Sexual Minorities: 473–505. doi:10.1007/978-0-387-31334-4_19. ISBN 978-0-387-28871-0.
- ^ Paul Peter Rosen (2009). Rosen's Breast Pathology. Lippincott Williams & Wilkins. pp. 31–. ISBN 978-0-7817-7137-5.
- ^ Worsley R, Santoro N, Miller KK, Parish SJ, Davis SR (March 2016). "Hormones and Female Sexual Dysfunction: Beyond Estrogens and Androgens--Findings from the Fourth International Consultation on Sexual Medicine". J Sex Med. 13 (3): 283–90. doi:10.1016/j.jsxm.2015.12.014. PMID 26944460.
- ^ Apgar BS, Greenberg G (October 2000). "Using progestins in clinical practice". Am Fam Physician. 62 (8): 1839–46, 1849–50. PMID 11057840.
- ^ a b Goletiani NV, Keith DR, Gorsky SJ (2007). "Progesterone: review of safety for clinical studies". Exp Clin Psychopharmacol. 15 (5): 427–44. doi:10.1037/1064-1297.15.5.427. PMID 17924777.
- ^ Bäckström T, Bixo M, Johansson M, Nyberg S, Ossewaarde L, Ragagnin G, Savic I, Strömberg J, Timby E, van Broekhoven F, van Wingen G (2014). "Allopregnanolone and mood disorders". Prog. Neurobiol. 113: 88–94. doi:10.1016/j.pneurobio.2013.07.005. PMID 23978486. S2CID 207407084.
- ^ a b c Davey DA (March 2018). "Menopausal hormone therapy: a better and safer future". Climacteric. 21 (5): 454–461. doi:10.1080/13697137.2018.1439915. PMID 29526116. S2CID 3850275.
- ^ Raj R, Korja M, Koroknay-Pál P, Niemelä M (2018). "Multiple meningiomas in two male-to-female transsexual patients with hormone replacement therapy: A report of two cases and a brief literature review". Surg Neurol Int. 9: 109. doi:10.4103/sni.sni_22_18. PMC 5991277. PMID 29930875.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - ^ Nota NM, Wiepjes CM, de Blok CJ, Gooren LJ, Peerdeman SM, Kreukels BP, den Heijer M (July 2018). "The occurrence of benign brain tumours in transgender individuals during cross-sex hormone treatment". Brain. 141 (7): 2047–2054. doi:10.1093/brain/awy108. PMID 29688280. S2CID 19934721.
- ^ Kuhl H (2011). "Pharmacology of Progestogens" (PDF). Journal für Reproduktionsmedizin und Endokrinologie-Journal of Reproductive Medicine and Endocrinology. 8 (1): 157–177.
- ^ Kuhl H, Schneider HP (August 2013). "Progesterone--promoter or inhibitor of breast cancer". Climacteric. 16 Suppl 1: 54–68. doi:10.3109/13697137.2013.768806. PMID 23336704. S2CID 20808536.
- ^ a b de Ziegler D, Fanchin R (2000). "Progesterone and progestins: applications in gynecology". Steroids. 65 (10–11): 671–9. doi:10.1016/S0039-128X(00)00123-9. PMID 11108875. S2CID 5867301.
- ^ a b Hermann AC, Nafziger AN, Victory J, Kulawy R, Rocci ML, Bertino JS (2005). "Over-the-counter progesterone cream produces significant drug exposure compared to a food and drug administration-approved oral progesterone product". J Clin Pharmacol. 45 (6): 614–9. doi:10.1177/0091270005276621. PMID 15901742.
- ^ Tollan A, Oian P, Kjeldsen SE, Eide I, Maltau JM (1993). "Progesterone reduces sympathetic tone without changing blood pressure or fluid balance in men". Gynecol. Obstet. Invest. 36 (4): 234–8. doi:10.1159/000292636. PMID 8300009.
- ^ Unfer, Vittorio; di Renzo, Gian; Gerli, Sandro; Casini, Maria (2006). "The Use of Progesterone in Clinical Practice: Evaluation of its Efficacy in Diverse Indications Using Different Routes of Administration". Current Drug Therapy. 1 (2): 211–219. doi:10.2174/157488506776930923. ISSN 1574-8855.
- ^ Brady BM, Anderson RA, Kinniburgh D, Baird DT (2003). "Demonstration of progesterone receptor-mediated gonadotrophin suppression in the human male". Clin. Endocrinol. (Oxf). 58 (4): 506–12. doi:10.1046/j.1365-2265.2003.01751.x. PMID 12641635.
- ^ A. Wayne Meikle (1 June 1999). Hormone Replacement Therapy. Springer Science & Business Media. pp. 383, 389. ISBN 978-1-59259-700-0.
- ^ Paynter MJ (March 2019). "Medication and Facilitation of Transgender Women's Lactation". J Hum Lact. 35 (2): 239–243. doi:10.1177/0890334419829729. PMID 30840524. S2CID 73466659.
- ^ Telis, Leon; Baum, Stephanie; Singer, Tomer; Berookhim, Boback M. (2019). "Fertility Issues in Transgender Care". Transgender Medicine. Contemporary Endocrinology. pp. 197–212. doi:10.1007/978-3-030-05683-4_11. ISBN 978-3-030-05682-7. ISSN 2523-3785.
- ^ a b Kozlov GI, Mel'nichenko GA, Golubeva IV (1985). "Sluchai laktorei u bol'nogo muzhskogo pola s transseksualizmom" [Case of galactorrhea in a transsexual male patient]. Probl Endokrinol (Mosk) (in Russian). 31 (1): 37–8. ISSN 0375-9660. PMID 4039061.
[...] castration and feminizing plastic surgery of the external genitalia was performed [...] Some time after the operation, the patient developed a renewed interest in life. After the surgical and hormonal correction, the patient irresistibly developed maternal instincts. Unmarried, the patient obtained permission for the adoption of a child, simulated pregnancy, and was discharged from the maternity hospital with a son. From the first days after the "birth", galactorrhea sharply increased, and spontaneous outflow of milk appeared, with galactorrhea (+++). The baby was breastfed up to 6 months of age. [...] Our message is the second in the world literature describing galactorrhea in a male patient with transsexualism. The first description of this kind was made in 1983 by R. [Flückiger] et al. (6). This observation demonstrates the independence of the mechanism of lactation development from one's genetic sex and is alarming with regard to the possibility of drug-induced galactorrhea development in men.
- ^ Foss, GL (January 1956). "Abnormalities of form and function of the human breast". Journal of Endocrinology. 14 (1): R6–R9.
Based on the theories of lactogenesis and stimulated by the success of Lyons, Li, Johnson & Cole [1955], who succeeded in producing lactation in male rats, an attempt was made to initiate lactogenesis in a male transvestist. Six years ago this patient had been given oestrogens. Both testes and penis were then removed and an artificial vagina was constructed by plastic surgery. The patient was implanted with 500 mg oestradiol in September 1954, and 600 mg in July 1955. The breasts were then developed more intensively with daily injections of oestradiol dipropionate and progesterone for 6 weeks. Immediately following withdrawal of this treatment, prolactin 22·9 mg was injected daily for 3 days without effect. After a second month on oestradiol and progesterone daily, combined injections of prolactin and somatotrophin were given for 4 days and suction was applied by a breast pump-four times daily. On the 4th and 5th days a few drops of colostrum were expressed from the right nipple.
- ^ Harold Gardiner-Hill (1958). Modern Trends in Endocrinology. Butterworth. p. 192.
Recently, an attempt has been made by Foss (1956) to initiate lactation in a castrated male transvestist. He was given an implant of 500 milligrams of oestradiol, and 10 months later, a further 600 milligrams of oestradiol, followed by daily injections of oestradiol dipropionate and progesterone for 6 weeks. Immediately after withdrawal of this treatment, 22·9 milligrams of prolactin were injected daily for 3 days but without effect. After a second month of treatment with oestradiol and progesterone daily, he was given combined injections of prolactin and somatotrophin for 4 days, suction with a breast-pump being employed 4 times daily. On the fourth and fifth days a few drops of colostrum were expressed from the right nipple. There is a possible application here of modern hormone knowledge to man, and further trials would be of interest.
- ^ Edward Flückiger; Emilio Del Pozo; Klaus von Werder (1982). Prolactin: Physiology, Pharmacology, and Clinical Findings. Springer-Verlag. p. 13. ISBN 978-3-540-11071-2.
[...] An observation (Wyss and Del Pozo unpublished) in a male transsexual showed that induction of lactation can be similarly achieved in the human male. [...]
- ^ Carla A. Pfeffer (2017). Queering Families: The Postmodern Partnerships of Cisgender Women and Transgender Men. Oxford University Press. pp. 19–. ISBN 978-0-19-990805-9.
Just 2 years later, Winfrey would feature another interview that elicited many of the same audience reactions. In this 2010 episode, lesbian partners Dr. Christine McGinn and Lisa Bortz beamed with joy as they held their infant twins. Again, audience members' jaws dropped when it was revealed that beautiful Christine was a male-to-female transsexual who used to be a handsome military officer Chris, and that Lisa had given birth to the couple's biological children using sperm Chris banked prior to gender confirmation surgeries.10 And it was Winfrey's chin that nearly hit the floor as she watched video of Christine breastfeeding the couples' children (the episode is referred to online as "The Mom Who Fathered Her Own Children"). [...]
- ^ Elliott S, Latini DM, Walker LM, Wassersug R, Robinson JW (September 2010). "Androgen deprivation therapy for prostate cancer: recommendations to improve patient and partner quality of life". J Sex Med. 7 (9): 2996–3010. doi:10.1111/j.1743-6109.2010.01902.x. PMID 20626600.
- ^ Higano CS (February 2003). "Side effects of androgen deprivation therapy: monitoring and minimizing toxicity". Urology. 61 (2 Suppl 1): 32–8. doi:10.1016/S0090-4295(02)02397-X. PMID 12667885.
- ^ Higano CS (October 2012). "Sexuality and intimacy after definitive treatment and subsequent androgen deprivation therapy for prostate cancer". J. Clin. Oncol. 30 (30): 3720–5. doi:10.1200/JCO.2012.41.8509. PMID 23008326.
- ^ Eberhard Nieschlag; Hermann Behre (29 June 2013). Andrology: Male Reproductive Health and Dysfunction. Springer Science & Business Media. pp. 54–. ISBN 978-3-662-04491-9.
- ^ a b Fisher, Alessandra Daphne; Maggi, Mario (2015). "Endocrine Treatment of Transsexual Male-to-Female Persons": 83–91. doi:10.1007/978-88-470-5696-1_10.
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(help) Cite error: The named reference "FisherMaggi2015" was defined multiple times with different content (see the help page). - ^ a b Radix, Asa E. (2016). "Medical Transition for Transgender Individuals": 351–361. doi:10.1007/978-3-319-19752-4_19.
{{cite journal}}
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- ^ de Blok CJ, Klaver M, Wiepjes CM, Nota NM, Heijboer AC, Fisher AD, Schreiner T, T'Sjoen G, den Heijer M (February 2018). "Breast Development in Transwomen After 1 Year of Cross-Sex Hormone Therapy: Results of a Prospective Multicenter Study". J. Clin. Endocrinol. Metab. 103 (2): 532–538. doi:10.1210/jc.2017-01927. PMID 29165635.
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- ^ Ekins, Richard (2016). "Science, Politics and Clinical Intervention: Harry Benjamin, Transsexualism and the Problem of Heteronormativity". Sexualities. 8 (3): 306–328. doi:10.1177/1363460705049578. ISSN 1363-4607. S2CID 143544267.
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Further reading
- Gooren LJ, Giltay EJ, Bunck MC (January 2008). "Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience". J. Clin. Endocrinol. Metab. 93 (1): 19–25. doi:10.1210/jc.2007-1809. PMID 17986639.
- Gooren LJ (March 2011). "Clinical practice. Care of transsexual persons". N. Engl. J. Med. 364 (13): 1251–7. doi:10.1056/NEJMcp1008161. PMID 21449788.
- Wierckx K, Gooren L, T'Sjoen G (2014). "Clinical review: Breast development in trans women receiving cross-sex hormones". J Sex Med. 11 (5): 1240–7. doi:10.1111/jsm.12487. PMID 24618412.
- Fabris B, Bernardi S, Trombetta C (March 2015). "Cross-sex hormone therapy for gender dysphoria". J. Endocrinol. Invest. 38 (3): 269–82. doi:10.1007/s40618-014-0186-2. PMID 25403429. S2CID 207503049.
- Tangpricha V, den Heijer M (April 2017). "Oestrogen and anti-androgen therapy for transgender women". Lancet Diabetes Endocrinol. 5 (4): 291–300. doi:10.1016/S2213-8587(16)30319-9. PMC 5366074. PMID 27916515.
- Unger CA (December 2016). "Hormone therapy for transgender patients". Transl Androl Urol. 5 (6): 877–884. doi:10.21037/tau.2016.09.04. PMC 5182227. PMID 28078219.
{{cite journal}}
: CS1 maint: unflagged free DOI (link) - Wesp LM, Deutsch MB (March 2017). "Hormonal and Surgical Treatment Options for Transgender Women and Transfeminine Spectrum Persons". Psychiatr. Clin. North Am. 40 (1): 99–111. doi:10.1016/j.psc.2016.10.006. PMID 28159148.
External links
- Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, Rosenthal SM, Safer JD, Tangpricha V, T'Sjoen GG (November 2017). "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline" (PDF). J. Clin. Endocrinol. Metab. 102 (11): 3869–3903. doi:10.1210/jc.2017-01658. PMID 28945902. S2CID 3726467.
- Coleman, E.; Bockting, W.; Botzer, M.; Cohen-Kettenis, P.; DeCuypere, G.; Feldman, J.; Fraser, L.; Green, J.; Knudson, G.; Meyer, W. J.; Monstrey, S.; Adler, R. K.; Brown, G. R.; Devor, A. H.; Ehrbar, R.; Ettner, R.; Eyler, E.; Garofalo, R.; Karasic, D. H.; Lev, A. I.; Mayer, G.; Meyer-Bahlburg, H.; Hall, B. P.; Pfaefflin, F.; Rachlin, K.; Robinson, B.; Schechter, L. S.; Tangpricha, V.; van Trotsenburg, M.; Vitale, A.; Winter, S.; Whittle, S.; Wylie, K. R.; Zucker, K. (2012). "Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7" (PDF). International Journal of Transgenderism. 13 (4): 165–232. doi:10.1080/15532739.2011.700873. ISSN 1553-2739. S2CID 39664779.
- Deutsch, Madeline (17 June 2016). "Guidelines for the Primary and Gender-Affirming Care of Transgender and Gender Nonbinary People" (PDF) (2nd ed.). University of California, San Francisco: Center of Excellence for Transgender Health. p. 28.
{{cite web}}
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suggested) (help) - Dahl, M; Feldman, JL; Goldberg, J; Jaberi, A (2015). "Endocrine Therapy for Transgender Adults in British Columbia: Suggested Guidelines" (PDF). Vancouver Coastal Health. Retrieved 15 August 2018.
- Bourns, Amy (2015). "Guidelines and Protocols for Comprehensive Primary Care for Trans Clients" (PDF). Sherbourne Health Centre. Retrieved 15 August 2018.
- Transgender HRT Research Repository