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{{PBB|geneid=84329}}
The HVCN1 gene codes for a [[voltage-gated proton channel]] that has been shown to allow proton transport into [[phagosome]]s<ref>{{Cite pmid|16483534}}</ref><ref>{{Cite pmid|20139987}}</ref> and out of many types of cells including [[spermatozoa]], [[Action potential|electrically excitable]] cells and [[Respiratory epithelium|respiratory epithelial]] cells.<ref>{{Cite pmid|20961760}}</ref> The proton-conducting HVCN1 channel has only transmembrane domains corresponding to the S1-S4 voltage sensing domains (VSD) of [[voltage-gated potassium channel]]s and [[Sodium channel#Voltage-gated|voltage-gated sodium channels]].<ref>{{Cite pmid|19233200}}</ref> Molecular simulation is consistent with a water-filled pore that can function as a "[[Grotthuss mechanism|water wire]]" for allowing hydrogen bonded H<sup>+</sup> to cross the membrane.<ref>{{Cite pmid|21843503}}</ref><ref>{{Cite pmid|20543828}}</ref> The HVCN1 protein has been shown to exist as a dimer with two functioning pores.<ref>{{Cite pmid|20023639}}</ref><ref>{{Cite pmid|20023640}}</ref> Like other VSD channels, HVCN1 channels conduct ions about 1000-fold slower than channels formed by tetrameric S5-S6 central pores<ref>{{Cite pmid|18801839}}</ref>
The '''HVCN1''' gene codes for a [[voltage-gated proton channel]] that has been shown to allow proton transport into [[phagosome]]s<ref>{{Cite pmid|16483534}}</ref><ref>{{Cite pmid|20139987}}</ref> and out of many types of cells including [[spermatozoa]], [[Action potential|electrically excitable]] cells and [[Respiratory epithelium|respiratory epithelial]] cells.<ref>{{Cite pmid|20961760}}</ref> The proton-conducting HVCN1 channel has only transmembrane domains corresponding to the S1-S4 voltage sensing domains (VSD) of [[voltage-gated potassium channel]]s and [[Sodium channel#Voltage-gated|voltage-gated sodium channels]].<ref>{{Cite pmid|19233200}}</ref> Molecular simulation is consistent with a water-filled pore that can function as a "[[Grotthuss mechanism|water wire]]" for allowing hydrogen bonded H<sup>+</sup> to cross the membrane.<ref>{{Cite pmid|21843503}}</ref><ref>{{Cite pmid|20543828}}</ref> The HVCN1 protein has been shown to exist as a dimer with two functioning pores.<ref>{{Cite pmid|20023639}}</ref><ref>{{Cite pmid|20023640}}</ref> Like other VSD channels, HVCN1 channels conduct ions about 1000-fold slower than channels formed by tetrameric S5-S6 central pores.<ref>{{Cite pmid|18801839}}</ref>

==References==
==References==
{{reflist}}
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal |author=Li SJ, Zhao Q, Zhou Q, ''et al.'' |title=The role and structure of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1. |journal=J. Biol. Chem. |volume=285 |issue= 16 |pages= 12047-54 |year= 2010 |pmid= 20147290 |doi= 10.1074/jbc.M109.040360 }}
*{{cite journal |author=Musset B, Smith SM, Rajan S, ''et al.'' |title=Oligomerization of the voltage-gated proton channel. |journal=Channels (Austin) |volume=4 |issue= 4 |pages= 260-5 |year= |pmid= 20676047 |doi= }}
*{{cite journal |author=Lishko PV, Botchkina IL, Fedorenko A, Kirichok Y |title=Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel. |journal=Cell |volume=140 |issue= 3 |pages= 327-37 |year= 2010 |pmid= 20144758 |doi= 10.1016/j.cell.2009.12.053 }}
*{{cite journal |author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal |author=Musset B, Capasso M, Cherny VV, ''et al.'' |title=Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes. |journal=J. Biol. Chem. |volume=285 |issue= 8 |pages= 5117-21 |year= 2010 |pmid= 20037153 |doi= 10.1074/jbc.C109.082727 }}
*{{cite journal |author=Petheo GL, Orient A, Baráth M, ''et al.'' |title=Molecular and functional characterization of Hv1 proton channel in human granulocytes. |journal=PLoS ONE |volume=5 |issue= 11 |pages= e14081 |year= 2010 |pmid= 21124855 |doi= 10.1371/journal.pone.0014081 }}
*{{cite journal |author=Sasaki M, Takagi M, Okamura Y |title=A voltage sensor-domain protein is a voltage-gated proton channel. |journal=Science |volume=312 |issue= 5773 |pages= 589-92 |year= 2006 |pmid= 16556803 |doi= 10.1126/science.1122352 }}
*{{cite journal |author=Lee SY, Letts JA, Mackinnon R |title=Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=105 |issue= 22 |pages= 7692-5 |year= 2008 |pmid= 18509058 |doi= 10.1073/pnas.0803277105 }}
*{{cite journal |author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal |author=Li SJ, Zhao Q, Zhou Q, Zhai Y |title=Expression, purification, crystallization and preliminary crystallographic study of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1. |journal=Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |volume=65 |issue= Pt 3 |pages= 279-81 |year= 2009 |pmid= 19255483 |doi= 10.1107/S1744309109003777 }}
*{{cite journal |author=Suenaga T, Arase H, Yamasaki S, ''et al.'' |title=Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function. |journal=Eur. J. Immunol. |volume=37 |issue= 11 |pages= 3197-207 |year= 2007 |pmid= 17948262 |doi= 10.1002/eji.200737052 }}
*{{cite journal |author=Iovannisci D, Illek B, Fischer H |title=Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T. |journal=J. Gen. Physiol. |volume=136 |issue= 1 |pages= 35-46 |year= 2010 |pmid= 20548053 |doi= 10.1085/jgp.200910379 }}
*{{cite journal |author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal |author=Musset B, Cherny VV, Morgan D, ''et al.'' |title=Detailed comparison of expressed and native voltage-gated proton channel currents. |journal=J. Physiol. (Lond.) |volume=586 |issue= 10 |pages= 2477-86 |year= 2008 |pmid= 18356202 |doi= 10.1113/jphysiol.2007.149427 }}
*{{cite journal |author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal |author=Ramsey IS, Moran MM, Chong JA, Clapham DE |title=A voltage-gated proton-selective channel lacking the pore domain. |journal=Nature |volume=440 |issue= 7088 |pages= 1213-6 |year= 2006 |pmid= 16554753 |doi= 10.1038/nature04700 }}
*{{cite journal |author=Sakata S, Kurokawa T, Nørholm MH, ''et al.'' |title=Functionality of the voltage-gated proton channel truncated in S4. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=107 |issue= 5 |pages= 2313-8 |year= 2010 |pmid= 20018719 |doi= 10.1073/pnas.0911868107 }}
{{refend}}

{{Ion channels|g4}}


[[Category:Ion channels]]
[[Category:Ion channels]]

Revision as of 04:13, 17 September 2011

Template:PBB The HVCN1 gene codes for a voltage-gated proton channel that has been shown to allow proton transport into phagosomes[1][2] and out of many types of cells including spermatozoa, electrically excitable cells and respiratory epithelial cells.[3] The proton-conducting HVCN1 channel has only transmembrane domains corresponding to the S1-S4 voltage sensing domains (VSD) of voltage-gated potassium channels and voltage-gated sodium channels.[4] Molecular simulation is consistent with a water-filled pore that can function as a "water wire" for allowing hydrogen bonded H+ to cross the membrane.[5][6] The HVCN1 protein has been shown to exist as a dimer with two functioning pores.[7][8] Like other VSD channels, HVCN1 channels conduct ions about 1000-fold slower than channels formed by tetrameric S5-S6 central pores.[9]

References

  1. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 16483534, please use {{cite journal}} with |pmid=16483534 instead.
  2. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20139987, please use {{cite journal}} with |pmid=20139987 instead.
  3. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20961760, please use {{cite journal}} with |pmid=20961760 instead.
  4. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 19233200, please use {{cite journal}} with |pmid=19233200 instead.
  5. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 21843503, please use {{cite journal}} with |pmid=21843503 instead.
  6. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20543828, please use {{cite journal}} with |pmid=20543828 instead.
  7. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20023639, please use {{cite journal}} with |pmid=20023639 instead.
  8. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 20023640, please use {{cite journal}} with |pmid=20023640 instead.
  9. ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18801839, please use {{cite journal}} with |pmid=18801839 instead.

Further reading

  • Li SJ, Zhao Q, Zhou Q; et al. (2010). "The role and structure of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1". J. Biol. Chem. 285 (16): 12047–54. doi:10.1074/jbc.M109.040360. PMID 20147290. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Musset B, Smith SM, Rajan S; et al. "Oligomerization of the voltage-gated proton channel". Channels (Austin). 4 (4): 260–5. PMID 20676047. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Lishko PV, Botchkina IL, Fedorenko A, Kirichok Y (2010). "Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel". Cell. 140 (3): 327–37. doi:10.1016/j.cell.2009.12.053. PMID 20144758.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Musset B, Capasso M, Cherny VV; et al. (2010). "Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes". J. Biol. Chem. 285 (8): 5117–21. doi:10.1074/jbc.C109.082727. PMID 20037153. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Petheo GL, Orient A, Baráth M; et al. (2010). "Molecular and functional characterization of Hv1 proton channel in human granulocytes". PLoS ONE. 5 (11): e14081. doi:10.1371/journal.pone.0014081. PMID 21124855. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  • Sasaki M, Takagi M, Okamura Y (2006). "A voltage sensor-domain protein is a voltage-gated proton channel". Science. 312 (5773): 589–92. doi:10.1126/science.1122352. PMID 16556803.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Lee SY, Letts JA, Mackinnon R (2008). "Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1". Proc. Natl. Acad. Sci. U.S.A. 105 (22): 7692–5. doi:10.1073/pnas.0803277105. PMID 18509058.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Li SJ, Zhao Q, Zhou Q, Zhai Y (2009). "Expression, purification, crystallization and preliminary crystallographic study of the carboxyl-terminal domain of the human voltage-gated proton channel Hv1". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65 (Pt 3): 279–81. doi:10.1107/S1744309109003777. PMID 19255483.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Suenaga T, Arase H, Yamasaki S; et al. (2007). "Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function". Eur. J. Immunol. 37 (11): 3197–207. doi:10.1002/eji.200737052. PMID 17948262. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Iovannisci D, Illek B, Fischer H (2010). "Function of the HVCN1 proton channel in airway epithelia and a naturally occurring mutation, M91T". J. Gen. Physiol. 136 (1): 35–46. doi:10.1085/jgp.200910379. PMID 20548053.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Musset B, Cherny VV, Morgan D; et al. (2008). "Detailed comparison of expressed and native voltage-gated proton channel currents". J. Physiol. (Lond.). 586 (10): 2477–86. doi:10.1113/jphysiol.2007.149427. PMID 18356202. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  • Ramsey IS, Moran MM, Chong JA, Clapham DE (2006). "A voltage-gated proton-selective channel lacking the pore domain". Nature. 440 (7088): 1213–6. doi:10.1038/nature04700. PMID 16554753.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Sakata S, Kurokawa T, Nørholm MH; et al. (2010). "Functionality of the voltage-gated proton channel truncated in S4". Proc. Natl. Acad. Sci. U.S.A. 107 (5): 2313–8. doi:10.1073/pnas.0911868107. PMID 20018719. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
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