TRPM5: Difference between revisions
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TRPM5 is a key component of [[taste]] transduction in the [[gustatory system]] of [[Bitter (taste)|bitter]], [[sweet]] and [[umami]] tastes being activated by high levels of intracellular [[calcium in biology|calcium]]. It has also been targeted as a possible contributor to fat [[taste]] signaling.<ref>{{pmid|21557960}}</ref><ref>{{pmid|21653867}}</ref> The calcium dependent opening of TRPM5 produces a depolarizing generator potential which leads to an [[action potential]].<ref name="pmid20696704">{{cite journal | vauthors = Chaudhari N, Roper SD | title = The cell biology of taste | journal = J. Cell Biol. | volume = 190 | issue = 3 | pages = 285–96 |date=August 2010 | pmid = 20696704 | pmc = 2922655 | doi = 10.1083/jcb.201003144 }}</ref> |
TRPM5 is a key component of [[taste]] transduction in the [[gustatory system]] of [[Bitter (taste)|bitter]], [[sweet]] and [[umami]] tastes being activated by high levels of intracellular [[calcium in biology|calcium]]. It has also been targeted as a possible contributor to fat [[taste]] signaling.<ref>{{pmid|21557960}}</ref><ref>{{pmid|21653867}}</ref> The calcium dependent opening of TRPM5 produces a depolarizing generator potential which leads to an [[action potential]].<ref name="pmid20696704">{{cite journal | vauthors = Chaudhari N, Roper SD | title = The cell biology of taste | journal = J. Cell Biol. | volume = 190 | issue = 3 | pages = 285–96 |date=August 2010 | pmid = 20696704 | pmc = 2922655 | doi = 10.1083/jcb.201003144 }}</ref> |
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TPRM5 is also expressed in pancreatic [[beta_cell|β-cells]]<ref>{{cite journal|last1=Colsoul|first1=B.|last2=Schraenen|first2=A.|last3=Lemaire|first3=K.|last4=Quintens|first4=R.|last5=Van Lommel|first5=L.|last6=Segal|first6=A.|last7=Owsianik|first7=G.|last8=Talavera|first8=K.|last9=Voets|first9=T.|last10=Margolskee|first10=R. F.|last11=Kokrashvili|first11=Z.|last12=Gilon|first12=P.|last13=Nilius|first13=B.|last14=Schuit|first14=F. C.|last15=Vennekens|first15=R.|title=Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice|journal=Proceedings of the National Academy of Sciences|date=1 March 2010|volume=107|issue=11|pages=5208–5213|doi=10.1073/pnas.0913107107|url=http://www.pnas.org/content/107/11/5208}}</ref>. The potentiation of TRPM5 in the β-cells leads to increased [[insulin]] secretion and protects against the development of [[type 2 diabetes]] in mice<ref>{{cite journal|last1=Philippaert|first1=Koenraad|last2=Pironet|first2=Andy|last3=Mesuere|first3=Margot|last4=Sones|first4=William|last5=Vermeiren|first5=Laura|last6=Kerselaers|first6=Sara|last7=Pinto|first7=Sílvia|last8=Segal|first8=Andrei|last9=Antoine|first9=Nancy|last10=Gysemans|first10=Conny|last11=Laureys|first11=Jos|last12=Lemaire|first12=Katleen|last13=Gilon|first13=Patrick|last14=Cuypers|first14=Eva|last15=Tytgat|first15=Jan|last16=Mathieu|first16=Chantal|last17=Schuit|first17=Frans|last18=Rorsman|first18=Patrik|last19=Talavera|first19=Karel|last20=Voets|first20=Thomas|last21=Vennekens|first21=Rudi|title=Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity|journal=Nature Communications|date=31 March 2017|volume=8|pages=14733|doi=10.1038/ncomms14733|url=http://www.nature.com/articles/ncomms14733}}</ref>. Further expression of TRPM5 can be found in [[tuft cells]]<ref>{{cite journal|last1=Kaske|first1=S|last2=Krasteva|first2=G|last3=König|first3=P|last4=Kummer|first4=W|last5=Hofmann|first5=T|last6=Gudermann|first6=T|last7=Chubanov|first7=V|title=TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells.|journal=BMC neuroscience|date=4 July 2007|volume=8|pages=49|pmid=17610722}}</ref>, solitary chemosensory cells and several other cell types in the body that have a sensory role. |
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TPRM5 is also expressed in [[tuft cells]]. |
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== See also == |
== See also == |
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Revision as of 08:52, 4 April 2017
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| Aliases | TRPM5, LTRPC5, MTR1, transient receptor potential cation channel subfamily M member 5 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604600; MGI: 1861718; HomoloGene: 22818; GeneCards: TRPM5; OMA:TRPM5 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Transient receptor potential cation channel subfamily M member 5 (TRPM5), also known as long transient receptor potential channel 5 is a protein that in humans is encoded by the TRPM5 gene.[5][6]
Function
TRPM5 is a key component of taste transduction in the gustatory system of bitter, sweet and umami tastes being activated by high levels of intracellular calcium. It has also been targeted as a possible contributor to fat taste signaling.[7][8] The calcium dependent opening of TRPM5 produces a depolarizing generator potential which leads to an action potential.[9]
TPRM5 is also expressed in pancreatic β-cells[10]. The potentiation of TRPM5 in the β-cells leads to increased insulin secretion and protects against the development of type 2 diabetes in mice[11]. Further expression of TRPM5 can be found in tuft cells[12], solitary chemosensory cells and several other cell types in the body that have a sensory role.
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000070985 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000009246 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Prawitt D, Enklaar T, Klemm G, Gärtner B, Spangenberg C, Winterpacht A, Higgins M, Pelletier J, Zabel B (January 2000). "Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression". Hum. Mol. Genet. 9 (2): 203–16. doi:10.1093/hmg/9.2.203. PMID 10607831.
- ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100.
- ^ PMID 21557960
- ^ PMID 21653867
- ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. doi:10.1083/jcb.201003144. PMC 2922655. PMID 20696704.
- ^ Colsoul, B.; Schraenen, A.; Lemaire, K.; Quintens, R.; Van Lommel, L.; Segal, A.; Owsianik, G.; Talavera, K.; Voets, T.; Margolskee, R. F.; Kokrashvili, Z.; Gilon, P.; Nilius, B.; Schuit, F. C.; Vennekens, R. (1 March 2010). "Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice". Proceedings of the National Academy of Sciences. 107 (11): 5208–5213. doi:10.1073/pnas.0913107107.
- ^ Philippaert, Koenraad; Pironet, Andy; Mesuere, Margot; Sones, William; Vermeiren, Laura; Kerselaers, Sara; Pinto, Sílvia; Segal, Andrei; Antoine, Nancy; Gysemans, Conny; Laureys, Jos; Lemaire, Katleen; Gilon, Patrick; Cuypers, Eva; Tytgat, Jan; Mathieu, Chantal; Schuit, Frans; Rorsman, Patrik; Talavera, Karel; Voets, Thomas; Vennekens, Rudi (31 March 2017). "Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity". Nature Communications. 8: 14733. doi:10.1038/ncomms14733.
- ^ Kaske, S; Krasteva, G; König, P; Kummer, W; Hofmann, T; Gudermann, T; Chubanov, V (4 July 2007). "TRPM5, a taste-signaling transient receptor potential ion-channel, is a ubiquitous signaling component in chemosensory cells". BMC neuroscience. 8: 49. PMID 17610722.
Further reading
- Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
- Liman ER (2007). "TRPM5 and taste transduction". Handb Exp Pharmacol. Handbook of Experimental Pharmacology. 179 (179): 287–98. doi:10.1007/978-3-540-34891-7_17. ISBN 978-3-540-34889-4. PMID 17217064.
- Holzer P (July 2011). "Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system". Pharmacology and Therapeutics. 131 (1): 142–170. doi:10.1016/j.pharmthera.2011.03.006. PMC 3107431. PMID 21420431.
- Boesmans W, Owsianik G, Tack J, Voets T, Vanden Berghe P (January 2011). "TRP channels in neurogastroenterology: opportunities for therapeutic intervention". British Journal of Pharmacology. 162 (1): 18–37. doi:10.1111/j.1476-5381.2010.01009.x. PMC 3012403. PMID 20804496.
- Emily R Liman (2010). "Changing Taste by Targeting the Ion Channel TRPM5". The Open Drug Discovery Journal. 2: 98–102.
- Brixel LR, Monteilh-Zoller MK, Ingenbrandt CS, Fleig A, Penner R, Enklaar T, Zabel BU, Prawitt D (June 2010). "TRPM5 regulates glucose-stimulated insulin secretion". Pflugers Archive - European Journal of Physiology. 460 (1): 69–76. doi:10.1007/s00424-010-0835-z. PMID 20393858.
- Oliveira-Maia AJ, Stapleton-Kotloski JR, Lyall V, Phan TH, Mummalaneni S, Melone P, Desimone JA, Nicolelis MA, Simon SA (February 2009). "Nicotine activates TRPM5-dependent and independent taste pathways". Proceedings of the National Academy of Sciences of the United States of America. 106 (5): 1596–1601. doi:10.1073/pnas.0810184106. PMC 2635785. PMID 19164511.
- Dan Liu; Zheng Zhang; Emily R. Liman (May 2005). "Extracellular Acid Block and Acid-enhanced Inactivation of the Ca2+-activated Cation Channel TRPM5 Involve Residues in the S3-S4 and S5-S6 Extracellular Domains". The Journal of Biological Chemistry. 280 (21): 20691–20699. doi:10.1074/jbc.M414072200. PMID 15731110.
{{cite journal}}: Unknown parameter|last-author-amp=ignored (|name-list-style=suggested) (help)CS1 maint: unflagged free DOI (link) - Liu D, Liman ER (December 2003). "Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5". Proceedings of the National Academy of Sciences of the United States of America. 100 (25): 15160–15165. doi:10.1073/pnas.2334159100. PMC 299934. PMID 14657398.
- Wu LJ, Sweet TB, Clapham DE (September 2010). "International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family". Pharmacological Reviews. 62 (3): 381–404. doi:10.1124/pr.110.002725. PMC 2964900. PMID 20716668.
External links
- TRPM5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- IUPHAR
- HGNC Gene families
- Pfam
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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