Cannabis (drug)

A dried flowered bud of the Cannabis sativa plant.

For the plant see Cannabis.

Cannabis (also known as marijuana or ganja in its herbal form and hashish in its resinous form) is a psychoactive product of the plant Cannabis sativa L. subsp. indica (= C. indica Lam.). The herbal form of the drug consists of dried mature inflorescences and subtending leaves of pistillate ("female") plants. The resinous form consists primarily of glandular trichomes collected from the same plant material.

The major biologically active chemical compound in cannabis is Δ⁹-tetrahydrocannabinol, commonly referred to as THC. It has psychoactive and physiological effects when consumed, usually by smoking or ingestion. The minimum amount of THC required to have a perceptible psychoactive effect is about 5 mg. A related compound, Δ⁹-tetrahydrocannabidivarin, also known as THCV, is produced in appreciable amounts by certain drug strains. This cannabinoid has been described in the popular literature as having shorter-acting, flashier effects than THC, but recent studies suggest that it may actually inhibit the effects of THC. Relatively high levels of THCV are common in African dagga (marijuana), and in hashish from the northwest Himalayas. Humans have been consuming cannabis since prehistory, although in the 20th century there was a rise in its use for recreational, religious or spiritual, and medicinal purposes. It is estimated that cannabis is now regularly used by four percent of the world's adult population, with estimates of up to 20% or greater of the adult population in the United States having tried the drug, and 10–30% or greater using the herb in many European countries.

The possession, use, or sale of psychoactive cannabis products became illegal in most parts of the world in the early 20th century. Since then, some countries have intensified the enforcement of cannabis prohibition while others have reduced the priority of enforcement, almost to the point of legalization, as is the case in the Netherlands. The production of cannabis for drug use remains illegal throughout most of the world through the 1961 Single Convention on Narcotic Drugs, the 1971 Convention on Psychotropic Substances, and the 1988 United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances, while simple possession of small quantities is either legal, or treated as an addiction rather than a criminal offense in a few countries. The laws in the United States vary from state to state, some having decriminalized the possession of small amounts of marijuana although it is still a federal crime.

It has been reported that commercial hashish is often no more potent than high quality seedless marijuana. However, carefully produced and screened hashish is up to three times as potent as the highest quality herbal varieties.

Ancient history

Botanists have determined that Cannabis is native to central Asia, possibly extending southward into the Himalayas. Evidence of the inhalation of cannabis smoke can be found as far back as the Neolithic age, as indicated by charred Cannabis seeds found in a ritual brazier at an ancient burial site in present day Romania. The most famous users of cannabis were the ancient Hindus of India and Nepal, and the Hashshashins (hashish eaters) of present day Syria. The herb was called ganjika in Sanskrit (ganja in modern Indian and Nepali languages). The ancient drug soma, mentioned in the Vedas as a sacred intoxicating hallucinogen, was sometimes associated with cannabis.

Cannabis was also known to the Assyrians, who discovered its psychoactive properties through the Aryans. Using it in some religious ceremonies, they called it qunubu or the drug for sadness. Cannabis was also introduced by the Aryans to the Scythians and Thracians/Dacians, whose shamans (the kapnobatai - "those who walk on smoke/clouds") burned cannabis flowers to induce a state of trance. Members of the cult of Dionysus, believed to have originated in Thrace, are also thought to have inhaled cannabis smoke. In 2003, a leather basket filled with Cannabis leaf fragments and seeds was found next to a 2,500 to 2,800 year old mummified shaman in the northwestern Xinjiang Uygur Autonomous Region of China.

Cannabis has an ancient history of ritual use and is found in pharmacological cults around the world. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices by the Scythians occurred during the 5th to 2nd century BCE, confirming previous historical reports by Herodotus. Some historians and etymologists have claimed that cannabis was used as a religious sacrament by ancient Jews, early Christians and Muslims of the Sufi order. In India and Nepal, it has been used by some of the wandering spiritual sadhus for centuries, and in modern times the Rastafari movement has embraced it as a sacrament. Elders of the modern religious movement known as the Ethiopian Zion Coptic Church consider cannabis to be the Eucharist, claiming it as an oral tradition from Ethiopia dating back to the time of Christ. Like the Rastafari, some modern Gnostic Christian sects have asserted that cannabis is the Tree of Life. Other organized religions founded in the past century that treat cannabis as a sacrament are the THC Ministry, the Way of Infinite Harmony, Cantheism, the Cannabis Assembly and the Church of cognizance. Many individuals also consider their use of cannabis to be spiritual regardless of organized religion. When the ancient Hindus or Vedic "Dharmas" used this drug they would often pray for increased wisdom.

Medical use

Main article: Medical cannabis

Medical marijuana is a growing treatment for medical use. The American Marijuana Policy Project states that cannabis is an ideal therapeutic drug for cancer and AIDS patients, who often suffer from clinical depression, and from nausea and resulting weight loss due to chemotherapy and other aggressive treatments. [7] It is claimed that cannabis makes these other treatments more tolerable. The nausea suppression and mild analgesic effects of cannabis also provide a degree of relief for persons suffering from motion sickness, and it can also be used by hyperhidrosis sufferers for temporary relief of excessive sweating. A recent study by scientists in Italy has also shown that cannabidiol (CBD), a chemical found in marijuana, seriously inhibits the growth of cancer cells (including breast cancer) in animals. [8]. Both scientists and doctors agree that controlled doses of marijuana can help with Chemotherapy and Nausea Treatment, Appetite Stimulation, Glaucoma, Analgesia, and Movement Disorders.

Medical Uses

Chemotherapy and nausea have other treatments that utilize THC, the main chemical in marijuana, such as oral TITIC. The drug "[has] been effective in treating nausea associated with cancer chemotherapy if patients are pretreated and doses are repeated every 3 to 6 hours for approximately 24 hours."

Cannabis has also been proven to treat anorexia according to a report published by the BBC in 2003. . Medical marijuana will help with the lack of appetite due to AIDS or acquired immunodeficiency syndrome (the failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.). Those with severe cancer related anorexia would benefit from using controlled doses of THC Medical Use of Marijuana: Policy and Regulatory Issues.

Glaucoma, a condition of increased pressure within the eyeball causing gradual loss of sight, can be treated with medical marijuana to decrease this intraocular pressure. There has been debate for 25 years on the subject. There's some data showing a reduction of IOP in glaucoma patients who smoke marijuana, , but the effects are short-lived, and the frequency of doses needed to sustain a decreased IOP can cause systemic toxicity. There is also some concern over its use since it can also decrease blood flow to the optic nerve. Marijuana lowers IOP by acting on a cannabinoid receptor on the ciliary body called the CB receptor. Although marijuana is not a good therapeutic choice for glaucoma patients, it may lead researchers to more effective, safer treatments. In fact, a promising study shows that agents targeted to ocular CB can reduce IOP in glaucoma patients who have failed other therapies.

Medical marijuana is used for analgesia, or pain relief. “Marijuana is used for analgesia only in the context of a handful of illnesses [e.g., headache, dysentery, menstrual cramps, and depression] that are often cited by marijuana advocates as medical reasons to justify the drug being available as a prescription medication Medical Use of Marijuana: Policy and Regulatory Issues. It is also reported to be beneficial for treating certain neurological illnesses such as epilepsy, and bipolar disorder. Studies have found that cannabis can relieve tics in patients suffering from OCD and/or Tourette syndrome. Patients treated with marijuana reported a significant decrease in both motor and vocal tics, some of 50% or more. Some decrease in obsessive-compulsive behavior was also found. A recent study has also concluded that cannabinoids found in cannabis might have the ability to prevent Alzheimer's disease. THC has been shown to reduce arterial blockages. Marijuana has been used for centuries to relieve pain, but scientifically controlled studies confirming this use is almost nonexistent.

A recent epidemiological study funded by the National Institute of Health (NIH) concluded that, "the association of these [lung and upper aerodigestive tract] cancers with marijuana, even long-term or heavy use, is not strong and may be below practically detectable limits."

Another use for medical marijuana is movement disorders, although shown to work, does not have enough clinical support to regularly use for this purpose. “In the case of multiple sclerosis, IOM acknowledged that marijuana is frequently reported to reduce the muscle spasticity associated with the disease, but then it noted that these abundant anecdotal reports are not well-supported by clinical data. Evidence from animal studies [suggests that there is] a possible role for cannabinoids in the treatment of certain types of epileptic seizures” Medical Use of Marijuana: Policy and Regulatory Issues. The marijuana will numb the nervous system slightly so the body won’t go in to shock. A synthetic version of the major active compound in cannabis, THC, is available in capsule form as the prescription drug dronabinol (Marinol) in many countries. The prescription drug Sativex, an extract of cannabis administered as a sublingual spray has been approved in Canada for the treatment of multiple sclerosis. Dr. William Notcutt states that the use of MS as the disease to study "had everything to do with politics."

Government Debate

There are many claims regarding the use of cannabis in a medical context, both pro and con. [9][10] On April 20, 2006 the United States Food and Drug Administration (FDA) issued an intra-agency advisory warning against medical cannabis, restating the Drug Enforcement Administration's position that marijuana has a very high potential for abuse, no currently accepted medical use, and a lack of accepted safety for use under medical supervision. [11] The FDA also asserted that "there is currently sound evidence that smoked marijuana is harmful".

The official position of several medical organizations including the American Medical Association [12], the National Multiple Sclerosis Society [13], the American Glaucoma Society, the American Academy of Ophthalmology [14] and the American Cancer Society [15] is that they do not support smoking the herbal form of marijuana for medical use. [16][17] On June 6, 2005, the U.S. Supreme Court handed down a decision, which supported the Federal Government's position against "medical marijuana". [18] Justices O'Connor, Rehnquist, and Thomas filed dissenting opinions.

Chief Justice William H. Rehnquist, who was fighting thyroid cancer, disagreed with the Supreme Court ruling that allows federal prosecutions of ill medical marijuana users. Rehnquist, 80, joined a dissent written by Justice Sandra Day O'Connor that said the states should be allowed to set their own policies for cannabis use. O'Connor, who has had breast cancer, said that states should decide on their own "the difficult and sensitive question of whether marijuana should be available to relieve severe pain and suffering.” Currently the citizens of 12 states in the United States (upwards of 60 million people) have legalized cannabis for medical use, for treating certain illnesses. Additionally, six states have enacted decriminalization policies toward the drug. Because the federal government does not acknowledge any legitimate medical uses for cannabis, federal enforcement of prohibition continues in these states. United States federal law currently registers cannabis as a Schedule I drug (along with heroin and LSD), and Marinol as a Schedule III drug, despite the fact that they have the same active ingredient. [19] The medical use of cannabis is politically controversial, but physicians sometimes recommend it informally despite the risk of federal prosecution in the United States.

Relationship with other drugs

Since its origin in the 1950s, the "gateway drug" hypothesis has been one of the central pillars of marijuana drug policy in the United States, but this model of cause and effect has not been proven. Those who subscribe to this theory argue that cannabis use may lead one down the path of drug addiction, and should therefore be treated as a serious matter. Many researchers conclude that this model of behavior has little basis in fact, though other mental health professionals believe that studies support the "gateway drug" model. Despite the conflicting results of such studies, many researchers agree that the illegal status of cannabis has a direct connection to the "gateway theory". The reasoning goes that cannabis users are more likely than non-users to place themselves in situations where other illicit substances are being used. In order to acquire cannabis they are likely to become acquainted with people who use or sell other more stigmatized drugs such as cocaine or heroin, which may lead to serious addictions. Using this philosophy, activities such as smoking tobacco and drinking alcohol may also be regarded as having a gateway effect on youth.

The Lancet's scale to assess the harm of drugs

Indeed, certain studies have shown that tobacco smoking is a better predictor of concurrent illicit drug use than smoking cannabis. With this argument in mind, certain activist groups such as NORML contend that legalizing cannabis would substantially reduce the use of other drugs by taking the distribution of marijuana out of the hands of criminals, and regulating it in a similar manner to alcohol or tobacco. Government agencies such as the DEA, however, claim that legalization would do far more harm than good, and would likely cause a rise in cannabis use.

A study published in The Lancet 24 March 2007 finds that cannabis is both less harmful and less addictive than either alcohol or tobacco. Twenty drugs were assigned a risk from 0 to 3. Cannabis was ranked 17th out of 20 for harmfulness, while alcohol and tobacco were ranked 11th and 14th respectively. Cannabis was ranked 11th for dependence while alcohol was 6th and tobacco 3rd, behind heroin and cocaine.

New breeding and cultivation techniques

Main article: Cannabis (drug) cultivation

It is often claimed by growers and breeders of herbal cannabis that advances in breeding and cultivation techniques have increased the potency of cannabis since the late 1960s and early '70s. However, potent seedless marijuana such as "Thai sticks" were already available at that time. In fact, the sinsemilla technique of producing high potency ganja (marijuana) has been practiced in India for centuries. Sinsemilla (Spanish for without seed), is the dried, seedless inflorescences of female cannabis plants. Because THC production drops off once pollination occurs, the male plants (which produce little THC themselves) are eliminated before they shed pollen to prevent pollination. Advanced cultivation techniques such as hydroponics, cloning, high-intensity artificial lighting, and the sea of green method are frequently employed as a response (in part) to prohibition enforcement efforts that make outdoor cultivation more risky. These intensive horticultural techniques have led to fewer seeds being present in cannabis and a general increase in potency over the past 20 years.

Many opponents of cannabis use, both in and out of government, have exaggerated the increases in potency and ramifications thereof. In the United States, government advertisements encourage parents to disregard their own experiences with cannabis when speaking to their children, on the premise that the "pot" of today is significantly stronger, and thus more dangerous, than that which they used in the past. In proposed revisions to cannabis rescheduling in the U.K., the government is considering scheduling the more potent cannabis material as a separate, more restricted substance. Many cannabis proponents are vehemently opposed, reasoning that if one can smoke less cannabis to achieve the same effect, then it is safer in the long run than smoking a less potent product.

There are two recognized types of herbal cannabis, "sativa" and "indica". So-called "sativa" strains are reputed to induce a noticeably more "cerebral" high, while "indica" strains induce more of a body high. These two drug types are often hybridized or crossed with early-maturing (but low in THC) "ruderalis" strains to increase the range in desirable characteristics.

Preparations for human consumption

File:HOcannabis.jpg

Herbal cannabis "buds"

Cannabis is prepared for human consumption in several forms:

• Marijuana or ganja: the leaves and flowering tops of female plants

• Hashish or charas: a concentrated resin composed of glandular trichomes and vegetative debris that has been physically extracted, usually by rubbing, sifting, or with ice

Hash with 5p piece for size comparison

• Kief or kif: 1) the chopped flowering tops of female cannabis plants, often mixed with tobacco; 2) Moroccan hashish produced in the Rif mountains; 3) sifted cannabis trichomes consisting of only the glandular "heads" (often incorrectly referred to as "crystals" or "pollen") 4) The crystal (trichomes) left at the bottom of a grinder after grinding marijuana; then smoked.

• Bhang: a beverage prepared by grinding cannabis leaves in milk and boiling with spices and other ingredients
• Hash oil: an oily mixture resulting from chemical extraction or distillation of the THC-rich parts of the plant, THC usually ~ 10-20% and up to 70%

• Budder: hash oil whipped to incorporate air, making it more like butter

These forms are not exclusive, and mixtures of two or more different forms of cannabis are frequently consumed. Between the many different strains of cannabis and the various ways that it is prepared, there are innumerable variations similar to the wide variety of mixed alcoholic beverages that are consumed.

Smoking

Main article: Cannabis smoking

Variety of cannabis-smoking paraphernalia.

There are a wide variety of methods and apparatus for smoking cannabis. The most popular include the joint, the blunt, the bong, the pipe (more commonly called a "bowl" or "piece"), the shotgun, the chillum, the deffy and the one-hitter or "bat." Cannabis is sometimes smoked within a small enclosed area (such as a car) to trap the smoke, so that it is inhaled with every breath. This is often referred to as "hotboxing," "fishbowling," "baking," "jeaning," "clam-baking," "green-housing", "the aquarium" (in Belgium), creating a "potmosphere," or (in Australia), a "compression session." One can also smoke marijuana in a steam-filled environment (bathroom, sauna), with the added humidity intended to produce a greater high, called a "Jamaican shower".

File:Smokingthebowl3.PNG

Smoking cannabis out of a pipe

The classic bong is a tube with a small bowl (at the end of a thinner tube) inserted through the side, near the base. The bong is partially filled with water for the smoke to bubble through. The herb is placed in the bowl and ignited. After filling the tube with smoke, it is "cleared" by removing one's finger from a hole in the side called a "choke" (or "carb"), or by pulling the bowl up and out which is called a slide (or a "pull-carb"). Homemade bongs are sometimes made with plastic soda bottles. Smoking marijuana through a bong concentrates the smoke, and it is often followed by fits of coughing and laughter. Variants include the gravity bong (also known as a bucket bong), which consists of a cone atop a perforated or cut water bottle. This method of cannabis smoking is one of the most efficient, as the presence of a chamber and "carburetor" hole reduce smoke waste. With a bong, one can consume greater amounts of cannabis in one "hit" than with an ordinary pipe. Another similar smoking device is known as a "waterfall bong". This is usually made by poking a hole in the bottom of a plastic water bottle and either sticking a bowl through a hole in the cap, or resting the bowl over the top. The hole in the bottom is covered with a finger, and the bottle filled with water. The bowl is placed on top of the bottle and lit by holding a flame over it and moving the finger covering the hole. As the water drains out, a vacuum is created, pulling smoke into the bottle. When the water has all drained out, the bowl is removed and the smoke is sucked out of the bottle, often very quickly. The effects of this type of bong are usually felt almost immediately, and often very intensely. Pipes are usually made of blown glass, wood, or non-reactive metals. Metal pipes are often made of interchangeable pieces. Glass pipes often have a "carburetor" hole, colloquially referred to as a carb, rush, choke, shotgun, or shooter (British use) that is covered for suction and then released to draw a mixture of smoke and air into the lungs. Some users prefer vertically held pipes (chillums), or improvised pipes (e.g., "tinnies" or "foilies") made from aluminium foil, small plumbing fittings, soda cans, crisp fruits or vegetables, or the cardboard tubes from bathroom-tissue or aluminium foil rolls.

A "one-hitter" is a device that enables a small amount of cannabis to be burned and inhaled in a single breath. The cannabis is loaded into one end of a small screenless tube (usually brass), and the entire amount is smoked at once. This is repeated for each hit. This method is useful for carefully titrating the desired dose. One-hitters are often disguised to fool people into believing that one is smoking an authentic cigarette. This deception is more effective (but less healthy) if the cannabis is mixed with a little tobacco. The "apple Bowl" is yet another way of smoking cannabis. An apple is poked from the top and side creating a tube. Marijuana is then placed in the top opening and lit. The user then inhales the smoke from the other opening.

Marijuana has many psysical and psychological effects. Physical effects may include a dry mouth, dry and bloodshot eyes, puffy eyelids, and increased heart rate. Psychological effects include relaxation, euphoria, altered time perception, and alteration of visual, auditory, and olfactory senses. Marijuana does not seem to cause any major chronic effects. Short-term side effects of Marijuana use include short-term memory loss, anxiety, and irritation.

Vaporization

A vaporizer heats herbal cannabis to 365–410 °F (185–210 °C), which turns the active ingredients into gas without burning the plant material (the boiling point of THC is 200°C at 0.02 mm Hg pressure, and somewhat higher at standard atmospheric pressure). Toxic chemicals are released at much lower levels than by smoking, although this may vary depending on the design of the vaporizer and the temperature at which it is set. A study by MAPS/NORML, using a Volcano^tm vaporizer reported 95% THC and no toxins delivered in the vapor. However, an older study using less sophisticated vaporizers found more toxins. The effects from a vaporizer are noticeably different to that of smoking cannabis. Users have reported a more euphoric hallucinogen type high which is due to the more pure amount of THC being taken in.

Eating cannabis

As an alternative to smoking, cannabis may be consumed orally. Although hashish is sometimes eaten raw or mixed with water, THC and other cannabinoids are more efficiently absorbed into the bloodstream when dissolved in ethanol, or combined with butter or other lipids. The effects of cannabis administered this way take longer to begin, but last longer. They are sometimes perceived as more physical than mental, although there are many claims to the contrary. An oral dose of cannabis is often considered to give a more intense experience than the equivalent dose of smoked cannabis. Some people report unpleasant experiences after ingesting cannabis, because they experience a more intense effect than they are comfortable with.

Smoking cannabis results in a significant loss of THC and other cannabinoids in the exhaled smoke, by decomposition on burning, and in smoke that is not inhaled. In contrast, all of the active constituents enter the body when cannabis is ingested. It has been shown that the primary active component of cannabis, Δ9-THC, is converted to the more psychoactive 11-hydroxy-THC by the liver. Titration to the desired effect by ingestion is much more difficult than through inhalation.

A common method of preparation involves blending cannabis material with butter to create "cannabutter", which is used in preparing foods such as brownies, fudge, cookies, "ganja goo balls," and "space cakes". Before blending with melted butter, the plant material is often finely ground, almost to a powder. A more refined form of cannabutter is prepared by heating cannabis material with butter and water for an extended period of time, without bringing to a complete boil. The vegetative material is then removed by filtering through a strainer or cheese cloth, and the water and butter are allowed to separate, leaving clarified cannabutter to be used in various recipes. However, some recipes do not contain butter and fall into a slightly different category; these delicacies include the "Leary biscuit," which require less work to prepare than more "conventional" recipes. Cannabis infusions (known as Bhang) containing milk, spices, and other ingredients are commonly consumed in India and elsewhere, especially on festive occasions.

In 2006, hollowed-out gumballs filled with cannabis material and labeled as "Greenades" were distributed by high school students in the United States.

As with other drugs taken orally, it is sometimes customary to fast before eating cannabis to increase the effect, possibly because an empty stomach will enable the THC to enter the bloodstream more quickly. However, some people eat ordinary food before consuming the drug, because eating it on an empty stomach can cause nausea. The time to onset of effects is usually about an hour and may continue for a considerable length of time, whereas the effects of smoking herbal cannabis are almost immediate.

Cannabis material can be leached in high-proof spirits (often grain alcohol) to create "Green Dragon." This process is often employed to make use of low-potency stems and leaves.

Cannabis can also be consumed as a tea. Although THC is lipophilic and only slightly water soluble (with a solubility of 2.8 grams per litre), enough THC can be dissolved to make a mildly psychoactive tea. However, water-based infusions are generally considered to be an inefficient use of the herb.

Cannabis "seeds" (technically called achenes), which are not psychoactive, are high in protein and essential fatty acids, and are readily consumed by many species of birds. They are also consumed by humans, and are a key ingredient in certain traditional recipes in Europe, and elsewhere. In many countries, including the United States and Canada, possession of viable cannabis seeds is illegal.

Immediate effects of consumption

The nature and intensity of the immediate (as opposed to long-term) effects of cannabis consumption vary depending on such factors as dose, potency, cannabinoid (and possibly terpenoid) composition, method of consumption, length of time since last usage, the user's mental and physical state, and their surroundings. These last two factors are sometimes referred to as set and setting. Smoking the same cannabis material in different frames of mind (set) or in different locations (setting) can alter the effects of the drug, or one's perception of the effects. What the user does while under the influence of cannabis can also alter the effects. If the user is inactive they may feel relaxed and sleepy, whereas if the user engages in physical or mental activity they may feel energized. The effects of cannabis consumption may be loosely classified as cognitive and physical. Anecdotal evidence suggests that sativa drug varieties tend to produce greater cognitive or perceptual effects than indica varieties, which tend to produce more physical effects.

The high

Cannabis intoxication is the state of being intoxicated to a degree that mental and physical facilities are noticeably altered due to the consumption of cannabis. Each user experiences a different high, and the nature of it may vary upon factors such as potency, dose, chemical composition, method of consumption and set and setting.

Highs vary from:

• A feeling of euphoria
• Intense relaxation
• Most experience pleasure, but one out of five users experience a great deal of anxiety.
• Decrease in nausea (used medicinally for this)
• Laughter, giggle fits
• Sensory enhancement (colours, taste, sensation)
• Increased appreciation of music

Side effects include:

• Forgetfulness
• Laziness
• Distorted perception
• Trouble with concentration
• Paranoia
• Increased heart rate
• Dry mouth and throat
• Increased appetite
• Sensory confusion (random bad tastes, smells, sensations)

"Munchies"

The "Munchies" is a term that is often used to describe the increased appetite that comes from using Cannabis. Research performed by the National Institutes of Health claimed that marijuana increases food enjoyment and the number of times a person eats each day. Recently, scientists have claimed to be able to explain what causes the increase in appetite, concluding that "endocannabinoids in the hypothalamus activate cannabinoid receptors that are responsible for maintaining food intake.". Additionally, studies have suggested that consumption of chocolate results in a dopamine-serotonin release in the brain that is magnified greatly during the high.

Toxicity

According to the Merck Index, the LD50 (dosage lethal to 50% of rats tested) of Δ⁹-THC by inhalation is 42 mg/kg of body weight. That is the equivalent of a 165 lb (75 kg) man inhaling the THC found in 21 grams of extremely high-potency (15% THC) marijuana all in one sitting, assuming no THC is lost through smoke loss or absorption by the lungs. For oral consumption, the LD50 for male rats is 1270 mg/kg, and 730 mg/kg for females—equivalent to the THC in about a pound of 15% THC marijuana. The ratio of cannabis material required to saturate cannabinoid receptors to the amount required for a fatal overdose is 1:40,000. There have been no reported deaths or permanent injuries sustained as a result of a marijuana overdose. It is practically impossible to overdose on marijuana, as the user would certainly either fall asleep or otherwise become incapacitated from the effects of the drug before being able to consume enough THC to be mortally toxic. While it has never been reported, it is theoretically feasible for concentrated THC (hash or oil) to cause an overdose. We also learn by comparing LD50s that the toxicity of the cannabis is significantly lower than that of the alcohol or other frequently consumed products.

Adulterated Cannabis

Contaminants are rife in street cannabis; low-quality hashish such as soap bar has a reputation for being full of contaminants (some psychoactive, some not) which serve to increase the bulk of the street product . Recently, there have been reports of herbal cannabis being adulterated with minute silica crystals in the UK and Ireland. These crystals resemble THC in appearance, yet are much heavier, and so serve again to increase the weight, and hence value, of the cannabis on the street.

Health issues and the effects of cannabis

Main article: Health issues and the effects of cannabis

Although there are many conflicting studies involving health issues and the effects of cannabis, certain physical and mental health effects conclusions have been reached. Today, there is still a substantial amount of propaganda and misinformation from both cannabis advocates and opponents due to the legal issues of cannabis, including legal and political constraints on cannabis research.

Cannabis is currently recognized as a psychologically addictive drug. There is no cannabis withdrawal disorder in the DSM-IV, but studies have demonstrated that cannabis use can induce withdrawal symptoms similar to other drugs with recognized physical dependence. Cannabis withdrawal symptoms are similar in magnitude and time-course to the well-established tobacco withdrawal syndrome.

The most obvious confounding factor in cannabis research is the prevalent usage of other recreational drugs, including alcohol and tobacco. Such complications demonstrate the need for studies on cannabis that have stronger controls, and investigations into the symptoms of cannabis use that may also be caused by tobacco. Most cannabis research within the USA is funded by government agencies who in turn publish position papers citing research studies that spotlight the negative consequences of cannabis use. In light of this, some people question whether these agencies make an honest effort to present an accurate, unbiased summary of the evidence, or whether they "cherry-pick" their data, and others caution that the raw data, and not the final conclusions, are what should be examined.

On 23 May 2006, Donald Tashkin, M.D., Professor of Medicine at the David Geffen School of Medicine at UCLA in Los Angeles announced that the use of Marijuana does not appear to increase the risk of developing lung cancer, or increase the risk of head and neck cancers, such as cancer of the tongue, mouth, throat, or esophagus.The study involved 2252 participants, with some of the most chronic marihuana smokers having smoked over 22,000 marihuana cigarettes. The finding of Donald Tashkin, M.D., and his team of researchers in 2006 refines their earlier studies published in a Dec. 17 2000 edition of the peer-reviewed journal Cancer Epidemiology Biomarker and Prevention.[20] Many opponents of marihuana incorrectly cite the original finding of UCLA Medical Center from 2000 as "proof" that marihuana use leaves the users at higher risk for cancer of the lung, and cancerous tumors, even though the researchers at the UCLA Medical Center have revised their finding with a more in-depth study on the effects of the use of marihuana.

However, contrasting studies have linked the smoking of cannabis to lung cancer and the growth of cancerous tumors. A 2002 report by the British Lung Foundation estimated that three to four cannabis cigarettes a day were associated with the same amount of damage to the lungs as 20 or more tobacco cigarettes a day. Other studies have suggested that cannabis use by expectant mothers does not appear to cause birth defects or developmental delays in their newborn children. According to a United Kingdom government report, using cannabis is less dangerous than tobacco, prescription drugs, and alcohol in social harms, physical harm and addiction.

Cannabis is known to act on the hippocampus (an area of the brain associated with memory and learning), and impair short term memory and attention for the duration of its effects and in some cases for the next day. In the long term, some studies point to enhancement of particular types of memory. Cannabis was found to be neuroprotective against excitotoxicity and is therefore beneficial for the prevention of progressive degenerative diseases like Alzheimer's disease. A 1998 report commissioned in France by Health Secretary of State Bernard Kouchner and directed by Dr. Pierre-Bernard Roques determined that, "former results suggesting anatomic changes in the brain of chronic cannabis users, measured by tomography, were not confirmed by the accurate modern neuro-imaging techniques," (like MRI). "Moreover, morphological impairment of the hippocampus [which plays a part in memory and navigation] of rat after administration of very high doses of THC (Langfield et al., 1988) was not shown (Slikker et al., 1992)" (translated). He concluded that cannabis does not have any neurotoxicity as defined in the report, unlike alcohol and cocaine.

Research between the use of cannabis and mental illness has also brought significant results. Cannabis use is generally higher among sufferers of schizophrenia, but the causality between the two has not been established. Another study concluded that sustained early-adolescent cannabis use among genetically predisposed individuals has been associated with a variety of mental illness outcomes, ranging from psychotic episodes to clinical schizophrenia.

Legality

World laws on cannabis possession (small amount). Data is from multiple sources detailed on the full source list. This map is a work in progress. Please give corrections and additions here.

European laws on cannabis possession (small amount). Data is from multiple sources detailed on the full source list. This map is a work in progress. Please give corrections and additions here.

Main article: Legal issues of cannabis

Since the 20th century, most countries have enacted laws against the cultivation, use, possession, or transfer of cannabis for recreational use. Naturally, these laws impact adversely on the cannabis plant's cultivation for non-recreational purposes, but there are many regions where, under certain circumstances, handling of cannabis is legal or licensed, and others where laws against its use, possession, or sale are not enforced. Many jurisdictions have also decriminalized possession of small quantities of cannabis, so that it is punished by confiscation or a fine, rather than imprisonment. By effectively removing the user from the criminal justice system, decriminalization focuses more on those who traffic and sell the drug on the black market. However, this does not solve the problem of how a user will obtain the "legal amount" of cannabis, since buying or growing cannabis is still illegal. Increasingly, many jurisdictions also permit cannabis use for medicinal purposes. Some countries allow the sale through drug companies. However, simple possession can carry long jail sentences in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution.

United States cannabis laws. Blue represents states with medical cannabis laws; red represents states with decriminalization laws; purple represents states with both.

A large scale anti-prohibition demonstration in Vancouver, Canada, on April 20, 2005.

U.S. Federal Bureau of Narcotics PSA used in the late 1930s and 1940s.

Recent history

Under the name cannabis, 19th century medical practitioners sold the drug, (usually as a tincture) popularizing the word amongst English-speakers. It was rumoured to have been used to treat Queen Victoria's menstrual pains as her personal physician, Sir John Russell Reynolds, was a staunch supporter of the benefits of cannabis. Cannabis was also openly available from shops in the US. By the end of the 19th century, its medicinal use began to fall as other drugs like aspirin took over its use as a pain reliever.

In 1894, the Report of the Indian Hemp Drugs Commission commissioned by the UK Secretary of State and the government of India, was instrumental in the decision not to criminalize the drug in those countries. The Report, which at over 500 pages remains one of the most complete collections of information on cannabis in existence, shows the stark contrast in the way that the American and British governments went about deciding whether to criminalize cannabis. In 1937 the F.D. Roosevelt administration crafted the first national US law making cannabis possession illegal in the US via an unpayable tax on the drug. Hollywood supported that effort with the release of "misinformation documentaries" such as the iconical "Reefer Madness" (1937).

The name marijuana (Mexican Spanish marihuana, mariguana) is associated almost exclusively with the plant's psychoactive use. The term is now well known in English largely due to the efforts of American drug prohibitionists during the 1920s and 1930s, which deliberately used a Mexican name for cannabis in order to turn the populace against the idea that it should be legal, playing upon attitudes towards race. (See 1937 Marihuana Tax Act). Those who demonized the drug by calling it marihuana omitted the fact that the "deadly marihuana" was identical to cannabis indica, which had at the time a reputation for pharmaceutical safety.

Although cannabis has been used for its psychoactive effects since ancient times, it first became well known in the United States during the jazz music scene of the late 1920s and 1930s. Louis Armstrong became a prominent and life-long devotee. It was popular in the blues scene as well, and eventually became a prominent part of 1960s counterculture.

Decriminalization and legalization

Main article: Legal issues of cannabis

In recent decades, a movement to decriminalize cannabis has arisen in several countries. 12 US states have passed by majority vote of the citizenry, laws allowing some degree of medical use, while a further 6 states have taken steps to decriminalize it to some degree. This movement seeks to make simple possession of cannabis punishable by only confiscation or a fine, rather than prison. In the past several years, the movement has started to have some successes. These include Denver, Colorado legalizing possession of up to an ounce of cannabis, a broad coalition of political parties in Amsterdam, Netherlands unveiling a pilot program to allow farmers to grow it legally, and Massachusetts voting in favor of a bill to decriminalize the possession of up to an ounce of cannabis. These laws passed by states and cities to decriminalize marijuana do not result in marijuana being legal, however. The Federal Government has the power to regulate marijuana because of the Commerce Clause of the United States Constitution. Additionally, under the Supremacy Clause, any state law in conflict with federal law is not valid. These issues were squarely addressed by the United States Supreme Court in Raich v. Ashcroft, 352 F. 3d 1222.

In Alaska, cannabis was decided legal for in-home, personal use under the Ravin vs. State ruling in 1975. This ruling allowed up to four ounces of cannabis for these purposes. A 1991 voter ballot initiative recriminalized marijuana possession, but when that law was eventually challenged in 2004, the Alaska court's upheld the Ravin ruling, saying the popular vote could not trump the state constitution. In response to former Governor Frank Murkowski's successive attempt to re-criminalize cannabis, the ACLU filed a lawsuit against the state. On July 17, 2006, Superior Court Judge Patricia Collins awarded the Case Summary judgment to the ACLU. In her ruling, she said "No specific argument has been advanced in this case that possession of more than 1 ounce of cannabis, even within the privacy of the home, is constitutionally protected conduct under Ravin or that any plaintiff or ACLU of Alaska member actually possesses more than 1 ounce of cannabis in their homes." This does not mean that the legal possession threshold has been reduced to one ounce, as this was a mere case summary review filed by the ACLU, not a full case. Reinforcing Ravin, Collins wrote "A lower court cannot reverse the State Supreme Court's 1975 decision in Ravin v. State" and "Unless and until the Supreme Court directs otherwise, Ravin is the law in this state and this court is duty bound to follow that law". The law regarding possession of cannabis has not changed in Alaska, and the Supreme Court has declined to review the case, therefore the law still stands at 4 ounces.

In 2002, Nevada voters defeated a ballot question which would legalize up to 3 ounces for adults 21 and older by 39% to 61%. In 2006, a similar Nevada ballot initiative, which would have legalized and regulated the cultivation, distribution, and possession of up to 1 ounce of marijuana by adults 21 and older, was defeated by 44% to 56%.

In 2001 in the United Kingdom, it was announced that cannabis would become a Class C drug, rather than a Class B, this change took effect on January 29, 2004. Since then there has recently been some controversy amongst UK politicians about the message this sends out, with some calling for its reclassification to Class B.

The Government of Mexico voted to legalize the possession of cannabis under 5 grams on April 28, 2006. However, as of May 3, 2006, Mexican President Vicente Fox has said that he will not sign this proposed law until Congress removes the parts that would decriminalize the possession of small quantities of drugs and vetoed the bill on May 4, 2006, sparking broad controversy over the bill. In the early summer of 2006 Fox and the Mexican congress came to an agreement and legalized possession of small amounts (and also measured amounts of other drugs). On July 17, 2006, Italian Social Solidarity Minister Paolo Ferrero, speaking of the urgent need for depenalising the consumption of light drugs, said that "a joint is less harmful than a litre of wine." In the Australian Capital Territory, possession of up to 25 grams, or five plants, is not a criminal offence but carries a $100 fine. In South Australia however, possession of cannabis is an offense, with fines ranging from $150 to $300 for possession and cultivation of small amounts.[21] There is much confusion on the subject, with many people believing that possession of a certain amount is legal. In South Australia however, this is a myth.

Legality in Hong Kong

Cannabis is regulated under section 9 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Cultivation and dealing with cannabis plant is illegal and a fine of $100,000 and to imprisonment for 15 years can be laid by the court. Anyone who supplies the substance without prescription can be fined $10,000(HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 fine and/or 7 years of jail time.

Legality in the United States

Main article: Legal history of marijuana in the United States

See also: Cannabis rescheduling in the United States

See also: Decriminalization of marijuana in the United States

Under federal law, it is illegal to possess, use, buy, sell, or cultivate marijuana anywhere in the United States. The Controlled Substances Act of 1970 classifies marijuana as a Schedule I drug, meaning it has a high potential for abuse and no accepted medical use. Under the Supremacy Clause of the Constitution, Federal law in the United States preempts conflicting state and local laws. Nevertheless, some states and local governments have established laws attempting to decriminalize cannabis, which has reduced the number of "simple possession" offenders sent to jail, since federal enforcement agents rarely target individuals directly for such relatively minor offenses. Other state and local governments ask law enforcement agencies to limit enforcement of drug laws with respect to cannabis. In the 2006 election, amendment 44 of Colorado making it legal to possess less than 1 ounce of marijuana, failed and the election was 40-60, yet it is still a misdemeanor to possess up to one half pound, and is punished mainly by fines unless sale is established.

The National Center for Natural Products Research in Oxford, Mississippi is the only facility in the United States that is federally licensed by the National Institute on Drug Abuse to cultivate cannabis for scientific research. The Center is part of the School of Pharmacy at the University of Mississippi.

See also

• 420 (cannabis culture)
• BC Bud
• Bhang
• Cannabis coffee shops
• Cannabis political parties
• Cheech & Chong
• Drug policy of the Netherlands
• Drug test
• Eagle Bill
• Emerald Triangle
• Fitz Hugh Ludlow ("The Hasheesh Eater")
• Global Marijuana March
• Hash oil
• Head shop
• Health issues and the effects of cannabis
• Illegal drug trade
• Jack Herer
• Legal issues of cannabis
• Legality of cannabis by country
• List of cannabis strains
• Marc Emery
• National Organization for the Reform of Marijuana Laws
• Psychedelic drug
• Psychoactive drug
• Seed bank
• Shake
• Soap bar
• Soft drug
• Thai stick
• Stoner
• Stoner rock
• Victor Robinson
• War on Drugs
• Wiktionary appendix of cannabis slang

References

Bibliography

• Howard Markel (2002-10-27). "For Addicts, Relief May Be an Office Visit Away". New York Times. {{cite news}}: Check date values in: |date= (help)
• Louise Arsenault, Mary Cannon, Richie Poulton, Robin Murray, Avshalom Caspi, and Terrie E. Moffitt (2002). "Cannabis use in adolescence and risk for adult psychosis: longtudinal prospective study" (PDF). British Medical Journal. 325: 1212–1213.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Avshalom Caspi, Terrie E. Moffitt, Mary Cannon, Joseph McClay, Robin Murray, HonaLee Harrington, Alan Taylor, Louise Arsenault, Ben Williams, Antony Braithwaite, Richie Poulton, and Ian W. Craig (2005). "Moderation of the effect of adult-onset cannabis use on adult psychosis by a functional polymorphism in the Catchol-O-Methyltransferase gene: Longitudinal evidence of a gene X environment interaction" (PDF). Biol Psychiatry. 25: 1117–1127. {{cite journal}}: Cite has empty unknown parameter: |Author= (help)CS1 maint: multiple names: authors list (link)
• Henderson, Mark (2005-04-12). "One in four at risk of cannabis psychosis". The Times. {{cite news}}: Check date values in: |date= (help)
• Bruce Mirken and Neel Makwana (Aston Birmingham): "Psychosis, Hype And Baloney". AlterNet. 2005-03-07. {{cite news}}: Check date values in: |date= (help)
• James Huff and Po Chan (October 2000). "Antitumor Effects of THC". Environmental Health Perspectives. 108(10): Correspondence. PMID 11097557.{{cite journal}}: CS1 maint: year (link)
• Cannabis: A History (2005). Martin Booth - ISBN 0-312-32220-8
• Long term impact of Cannabis use of 16 year olds "Long-term impact of the Gatehouse Project on Cannabis use of 16-year-olds in Australia.(Research Papers)". journal of school health. 2004-01-01. {{cite news}}: Check date values in: |date= (help)

External links

• Various slang terms for cannabis
• Marijuana Growing
• Comprehensive Cannabis Faqs and Marijuana information