Keratin 3

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Keratin 3
Symbols KRT3 ; CK3; K3
External IDs OMIM148043 HomoloGene130909 GeneCards: KRT3 Gene
Species Human Mouse
Entrez 3850 n/a
Ensembl ENSG00000186442 n/a
UniProt P12035 n/a
RefSeq (mRNA) NM_057088 n/a
RefSeq (protein) NP_476429 n/a
Location (UCSC) Chr 12:
53.18 – 53.19 Mb
PubMed search [1] n/a

Keratin 3 also known as cytokeratin 3 is a protein that in humans is encoded by the KRT3 gene.[1][2] Keratin 3 is a type II cytokeratin. It is specifically found in the corneal epithelium together with keratin 12.

Mutations in the KRT3 encoding this protein have been associated with Meesmanns Corneal Dystrophy.[3]


  1. ^ Raimondi E, Moralli D, De Carli L, Ceratto N, Balzaretti M, Leube R, Collin C, Romano V (1994). "Assignment of the human cytokeratin 3 gene (KRT3) to 12q12-->q13 by FISH". Cytogenet. Cell Genet. 66 (3): 162–3. doi:10.1159/000133690. PMID 7510223. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  3. ^ Irvine AD, Corden LD, Swensson O, Swensson B, Moore JE, Frazer DG, Smith FJ, Knowlton RG, Christophers E, Rochels R, Uitto J, McLean WH (June 1997). "Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy". Nat. Genet. 16 (2): 184–7. doi:10.1038/ng0697-184. PMID 9171831.