KRT81

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KRT81
Identifiers
AliasesKRT81, HB1, Hb-1, KRTHB1, MLN137, ghHkb1, hHAKB2-1, keratin 81
External IDsOMIM: 602153 MGI: 1928858 HomoloGene: 55645 GeneCards: KRT81
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for KRT81
Genomic location for KRT81
Band12q13.13Start52,285,913 bp[1]
End52,291,534 bp[1]
RNA expression pattern
PBB GE KRT81 213711 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002281

NM_001166157

RefSeq (protein)

NP_002272

NP_001159629

Location (UCSC)Chr 12: 52.29 – 52.29 MbChr 15: 101.46 – 101.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.[5][6][7]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000205426 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000067615 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J (Nov 1995). "Sequence data and chromosomal localization of human type I and type II hair keratin genes". Exp Cell Res. 220 (2): 357–62. doi:10.1006/excr.1995.1326. PMID 7556444.
  6. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  7. ^ a b "Entrez Gene: KRT81 keratin 81".

Further reading[edit]