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Keratin 81, type II
Symbols KRT81 ; HB1; Hb-1; KRTHB1; MLN137; ghHkb1; hHAKB2-1
External IDs OMIM602153 HomoloGene55645 GeneCards: KRT81 Gene
RNA expression pattern
PBB GE KRT81 213711 at tn.png
More reference expression data
Species Human Mouse
Entrez 3887 64818
Ensembl ENSG00000205426 ENSMUSG00000067615
UniProt Q14533 Q9ERE2
RefSeq (mRNA) NM_002281 NM_001166157
RefSeq (protein) NP_002272 NP_001159629
Location (UCSC) Chr 12:
52.29 – 52.29 Mb
Chr 15:
101.46 – 101.46 Mb
PubMed search [1] [2]

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.[3]


  1. ^ Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J (Nov 1995). "Sequence data and chromosomal localization of human type I and type II hair keratin genes". Exp Cell Res 220 (2): 357–62. doi:10.1006/excr.1995.1326. PMID 7556444. 
  2. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889. 
  3. ^ a b "Entrez Gene: KRT81 keratin 81". 

Further reading[edit]