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Kinesin family member 5A
Protein KIF5A PDB 2kin.png
PDB rendering based on 2kin.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols KIF5A ; D12S1889; MY050; NKHC; SPG10
External IDs OMIM602821 MGI109564 HomoloGene55861 ChEMBL: 5295 GeneCards: KIF5A Gene
RNA expression pattern
PBB GE KIF5A 205318 at tn.png
More reference expression data
Species Human Mouse
Entrez 3798 16572
Ensembl ENSG00000155980 ENSMUSG00000074657
UniProt Q12840 P33175
RefSeq (mRNA) NM_004984 NM_001039000
RefSeq (protein) NP_004975 NP_001034089
Location (UCSC) Chr 12:
57.55 – 57.59 Mb
Chr 10:
127.23 – 127.26 Mb
PubMed search [1] [2]

Kinesin heavy chain isoform 5A is a protein that in humans is encoded by the KIF5A gene.[1][2][3]

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.[3]


KIF5A has been shown to interact with KLC1.[4][5]

See also[edit]


  1. ^ Hamlin PJ, Jones PF, Leek JP, Bransfield K, Lench NJ, Aldersley MA, Howdle PD, Markham AF, Robinson PA (Feb 1999). "Assignment of GALGT encoding beta-1, 4N-acetylgalactosaminyl-transferase (GalNAc-T) and KIF5A encoding neuronal kinesin (D12S1889) to human chromosome band 12q13 by assignment to ICI YAC 26EG10 and in situ hybridization.". Cytogenet Cell Genet 82 (3–4): 267–8. doi:10.1159/000015115. PMID 9858832. 
  2. ^ Reid E, Dearlove AM, Rhodes M, Rubinsztein DC (Oct 1999). "A new locus for autosomal dominant "pure" hereditary spastic paraplegia mapping to chromosome 12q13, and evidence for further genetic heterogeneity". Am J Hum Genet 65 (3): 757–63. doi:10.1086/302555. PMC 1377983. PMID 10441583. 
  3. ^ a b "Entrez Gene: KIF5A kinesin family member 5A". 
  4. ^ Rahman, A; Friedman D S; Goldstein L S (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. ISSN 0021-9258. PMID 9624122. 
  5. ^ Rahman, A; Kamal A; Roberts E A; Goldstein L S (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". J. Cell Biol. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. ISSN 0021-9525. PMC 2156125. PMID 10491391. 

Further reading[edit]