EA-3167

EA-3167
Identifiers
	IUPAC name 1-azabicyclo[2.2.2]octan-8-yl 2-cyclopentyl-2-hydroxy-2-phenylethanoate;
CAS Number	26758-53-2 ;
PubChem CID	33597;
CompTox Dashboard (EPA)	DTXSID60949567 ;
Chemical and physical data
Formula	C20H29NO3
Molar mass	329.433 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCC(C1)C(C2=CC=CC=C2)(C(=O)OC3CN4CCC3CC4)O;
	(verify)

EA-3167 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, in an attempt to develop non-lethal incapacitating agents. EA-3167 has identical effects to QNB, but is even more potent and longer lasting, with an effective dose when administered by injection of as little as 2.5μg/kg (i.e. 0.2 milligrams for an 80kg person), and a duration of 120-240 hours (5-10 days).^[1]^[2] However unlike QNB, EA-3167 was never weaponized or manufactured in bulk.

References

^ Wills H (1982). "Appendix I: Digest Report -- Anticholinergic Chemicals". In National Research Council (U.S.). Committee on Toxicology (ed.). Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Vol. 1. Washington, D.C.: National Academies Press. pp. 195–196. OCLC 35472774.
^ Ketchum JS (2006). Chemical Warfare Secrets Almost Forgotton. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks. ISBN 978-1-4243-0080-8.

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[1] Wills H (1982). "Appendix I: Digest Report -- Anticholinergic Chemicals". In National Research Council (U.S.). Committee on Toxicology (ed.). Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Vol. 1. Washington, D.C.: National Academies Press. pp. 195–196. OCLC 35472774.

[2] Ketchum JS (2006). Chemical Warfare Secrets Almost Forgotton. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War. ChemBooks. ISBN 978-1-4243-0080-8.

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See also

References