From Wikipedia, the free encyclopedia
Irampanel (INN, code name BIIR-561) is a drug which acts as a dual noncompetitive antagonist of the AMPA receptor and neuronal voltage-gated sodium channel blocker.[1][2] It was under development by Boehringer Ingelheim for the treatment of acute stroke/cerebral ischemia but never completed clinical trials for this indication.[3][4] Irampanel was also trialed, originally, for the treatment of epilepsy and pain, but these indications, too, were abandoned,[1] and the drug was ultimately never marketed.
See also
References
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Calcium | VDCCsTooltip Voltage-dependent calcium channels | |
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Potassium | VGKCsTooltip Voltage-gated potassium channels | |
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IRKsTooltip Inwardly rectifying potassium channel | |
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KCaTooltip Calcium-activated potassium channel | |
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K2PsTooltip Tandem pore domain potassium channel | |
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Sodium | VGSCsTooltip Voltage-gated sodium channels | |
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ENaCTooltip Epithelial sodium channel | |
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ASICsTooltip Acid-sensing ion channel | |
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Chloride | CaCCsTooltip Calcium-activated chloride channel | |
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CFTRTooltip Cystic fibrosis transmembrane conductance regulator | |
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Unsorted | |
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Others | TRPsTooltip Transient receptor potential channels | |
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LGICsTooltip Ligand gated ion channels | |
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AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor | |
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KARTooltip Kainate receptor | |
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NMDARTooltip N-Methyl-D-aspartate receptor | |
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Group I | mGluR1Tooltip Metabotropic glutamate receptor 1 | |
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mGluR5Tooltip Metabotropic glutamate receptor 5 | |
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Group II | mGluR2Tooltip Metabotropic glutamate receptor 2 | |
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mGluR3Tooltip Metabotropic glutamate receptor 3 | |
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Group III | mGluR4Tooltip Metabotropic glutamate receptor 4 | |
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mGluR6Tooltip Metabotropic glutamate receptor 6 | |
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mGluR7Tooltip Metabotropic glutamate receptor 7 | |
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mGluR8Tooltip Metabotropic glutamate receptor 8 | |
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