MYH7B

MYH7B
Identifiers
Aliases	MYH7B, MHC14, MYH14, myosin, heavy chain 7B, cardiac muscle, beta, myosin heavy chain 7B
External IDs	OMIM: 609928; MGI: 3710243; HomoloGene: 66117; GeneCards: MYH7B; OMA:MYH7B - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	35,002,437 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,476,227 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; muscle of thigh; ; left ventricle; ; right auricle; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; lateral nuclear group of thalamus; ; sperm;
	Top expressed in
	vascular smooth muscle; ; lens; ; neural layer of retina; ; left ventricle; ; soleus muscle; ; vasculature of trunk; ; superior frontal gyrus; ; cerebellar cortex; ; myocardium of atrium; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; actin binding; cytoskeletal motor activity; protein binding; ATP binding; actin filament binding; microtubule motor activity; microtubule binding;
Cellular component	myosin filament; membrane; myosin complex; cardiac myofibril;
Biological process	microtubule-based movement;
	Sources:Amigo / QuickGO
Orthologs
	57644
	668940
	ENSG00000078814
	ENSMUSG00000074652
	Q5JW45
	A2AQP0
	NM_020884; NM_033424
	NM_001085378
	NP_065935
	NP_001078847
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene.^[5]^[6]

Function

MYH7B is a slow-twitch myosin.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078814 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074652 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
^ ^a ^b Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi:10.1093/oxfordjournals.molbev.a004093. PMID 11919279.

Rossi AC, Mammucari C, Argentini C, et al. (2010). "Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles". J. Physiol. 588 (Pt 2): 353–64. doi:10.1113/jphysiol.2009.181008. PMC 2821527. PMID 19948655.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Deloukas P, Matthews LH, Ashurst J, et al. (2001). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
McGuigan K, Phillips PC, Postlethwait JH (2004). "Evolution of sarcomeric myosin heavy chain genes: evidence from fish". Mol. Biol. Evol. 21 (6): 1042–56. doi:10.1093/molbev/msh103. PMID 15014174.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hu Z, Liang J, Wang Z, et al. (2009). "Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women". Hum. Mutat. 30 (1): 79–84. doi:10.1002/humu.20837. PMID 18634034. S2CID 41225773.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000078814 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074652 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10819331-5] Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (April 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[pmid11919279-6] Desjardins PR, Burkman JM, Shrager JB, Allmond LA, Stedman HH (April 2002). "Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family". Mol. Biol. Evol. 19 (4): 375–93. doi:10.1093/oxfordjournals.molbev.a004093. PMID 11919279.

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Function

References

Further reading