The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure, and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.[7] Lamin B, along with heterochromatin, is anchored to the inner surface of the nuclear membrane by the lamin B receptor.
^Foisner, R; Gerace L (Jul 1993). "Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation". Cell. 73 (7). UNITED STATES: 1267–79. doi:10.1016/0092-8674(93)90355-T. ISSN0092-8674. PMID8324822.
^Liu NA, Sun J, Kono K, Horikoshi Y, Ikura T, Tong X, Haraguchi T, Tashiro S. Regulation of homologous recombinational repair by lamin B1 in radiation-induced DNA damage. FASEB J. 2015 Jun;29(6):2514-25. doi: 10.1096/fj.14-265546. Epub 2015 Mar 2. PMID: 25733566
Further reading
Gruenbaum Y, Wilson KL, Harel A, et al. (2000). "Review: nuclear lamins--structural proteins with fundamental functions". J. Struct. Biol. 129 (2–3): 313–23. doi:10.1006/jsbi.2000.4216. PMID10806082.
Djabali K, Portier MM, Gros F, et al. (1991). "Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments". Cell. 64 (1): 109–21. doi:10.1016/0092-8674(91)90213-I. PMID1986862. S2CID6246606.
Müller WE, Wenger R, Reuter P, et al. (1989). "Association of Tat protein and viral mRNA with nuclear matrix from HIV-1-infected H9 cells". Biochim. Biophys. Acta. 1008 (2): 208–12. doi:10.1016/0167-4781(80)90011-1. PMID2544227.
Eldridge R, Anayiotos CP, Schlesinger S, et al. (1984). "Hereditary adult-onset leukodystrophy simulating chronic progressive multiple sclerosis". N. Engl. J. Med. 311 (15): 948–53. doi:10.1056/NEJM198410113111504. PMID6472420.
Broers JL, Machiels BM, Kuijpers HJ, et al. (1997). "A- and B-type lamins are differentially expressed in normal human tissues". Histochem. Cell Biol. 107 (6): 505–17. doi:10.1007/s004180050138. PMID9243284. S2CID24088247.
Kowluru A (2000). "Evidence for the carboxyl methylation of nuclear lamin-B in the pancreatic beta cell". Biochem. Biophys. Res. Commun. 268 (2): 249–54. doi:10.1006/bbrc.2000.2107. PMID10679189.