Tropomodulin 4

TMOD4
Identifiers
Aliases	TMOD4, SK-TMOD, tropomodulin 4
External IDs	OMIM: 605834; MGI: 1355285; HomoloGene: 8355; GeneCards: TMOD4; OMA:TMOD4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	151,176,284 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,036,520 bp
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; Skeletal muscle tissue of rectus abdominis; ; tibialis anterior muscle; ; biceps brachii; ; muscle of thigh; ; gastrocnemius muscle; ; Skeletal muscle tissue of biceps brachii; ; deltoid muscle; ; body of tongue; ; granulocyte;
	Top expressed in
	triceps brachii muscle; ; sternocleidomastoid muscle; ; medial head of gastrocnemius muscle; ; temporal muscle; ; quadriceps femoris muscle; ; tibialis anterior muscle; ; vastus lateralis muscle; ; skeletal muscle tissue; ; muscle of thigh; ; digastric muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin filament binding; actin binding; tropomyosin binding;
Cellular component	cytoplasm; cytoskeleton; striated muscle thin filament; myofibril;
Biological process	pointed-end actin filament capping; muscle contraction; actin filament organization; myofibril assembly;
	Sources:Amigo / QuickGO
Orthologs
	29765
	50874
	ENSG00000163157
	ENSMUSG00000005628
	Q9NZQ9
	Q9JLH8
	NM_013353
	NM_016712
	NP_037485
	NP_057921
	Wikidata
View/Edit Human	View/Edit Mouse

Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.^[5]^[6]

Function

This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163157 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005628 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
^ Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM (October 1999). "Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle". J. Biol. Chem. 274 (40): 28466–75. doi:10.1074/jbc.274.40.28466. PMID 10497209.
^ "Entrez Gene: TMOD4, Tropomodulin 4 (muscle)".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cox PR, Siddique T, Zoghbi HY (2001). "Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4". BMC Genomics. 2: 7. doi:10.1186/1471-2164-2-7. PMC 59888. PMID 11716785.{{cite journal}}: CS1 maint: unflagged free DOI (link)
McElhinny AS, Kolmerer B, Fowler VM, et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments". J. Biol. Chem. 276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID 11016930.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163157 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005628 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10662549-5] Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.

[pmid10497209-6] Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM (October 1999). "Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle". J. Biol. Chem. 274 (40): 28466–75. doi:10.1074/jbc.274.40.28466. PMID 10497209.

[entrez-7] "Entrez Gene: TMOD4, Tropomodulin 4 (muscle)".

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Function

References

Further reading