KIF5A

KIF5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UXT, 4UXY, 4UY0
Identifiers
Aliases	KIF5A, D12S1889, MY050, NKHC, SPG10, kinesin family member 5A, NEIMY, ALS25
External IDs	OMIM: 602821; MGI: 109564; HomoloGene: 55861; GeneCards: KIF5A; OMA:KIF5A - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,586,633 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,099,217 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; right hemisphere of cerebellum; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; ganglionic eminence; ; C1 segment; ; amygdala; ; nucleus accumbens;
	Top expressed in
	globus pallidus; ; lateral geniculate nucleus; ; superior frontal gyrus; ; subiculum; ; lateral hypothalamus; ; pontine nuclei; ; anterior amygdaloid area; ; ventral tegmental area; ; medial geniculate nucleus; ; nucleus accumbens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; microtubule motor activity; microtubule binding; protein binding; cytoskeletal motor activity; plus-end-directed microtubule motor activity; ATP binding; kinesin binding; ATPase activity;
Cellular component	cytoplasm; cytosol; membrane; kinesin complex; neuronal cell body; ciliary rootlet; perinuclear region of cytoplasm; neuron projection; microtubule; cytoskeleton; dendrite cytoplasm; synapse; axon cytoplasm;
Biological process	protein localization; cytoskeleton-dependent intracellular transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; axon guidance; chemical synaptic transmission; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle-mediated transport; microtubule-based movement; anterograde dendritic transport of neurotransmitter receptor complex; synaptic vesicle transport; anterograde axonal protein transport; retrograde neuronal dense core vesicle transport;
	Sources:Amigo / QuickGO
Orthologs
	3798
	16572
	ENSG00000155980
	ENSMUSG00000074657
	Q12840
	P33175
	NM_004984; NM_001354705; NM_032624
	NM_001039000; NM_008447
	NP_004975; NP_001341634
	NP_001034089; NP_032473
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin heavy chain isoform 5A is a protein that in humans is encoded by the KIF5A gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

KIF5A has been shown to interact with KLC1.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155980 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074657 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hamlin PJ, Jones PF, Leek JP, Bransfield K, Lench NJ, Aldersley MA, Howdle PD, Markham AF, Robinson PA (February 1999). "Assignment of GALGT encoding beta-1, 4N-acetylgalactosaminyl-transferase (GalNAc-T) and KIF5A encoding neuronal kinesin (D12S1889) to human chromosome band 12q13 by assignment to ICI YAC 26EG10 and in situ hybridization. medjph@stjames.leeds.ac.uk". Cytogenet Cell Genet. 82 (3–4): 267–8. doi:10.1159/000015115. PMID 9858832.
^ Reid E, Dearlove AM, Rhodes M, Rubinsztein DC (October 1999). "A new locus for autosomal dominant "pure" hereditary spastic paraplegia mapping to chromosome 12q13, and evidence for further genetic heterogeneity". Am J Hum Genet. 65 (3): 757–63. doi:10.1086/302555. PMC 1377983. PMID 10441583.
^ "Entrez Gene: KIF5A kinesin family member 5A".
^ Rahman, A; Friedman D S; Goldstein L S (June 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". J. Biol. Chem. 273 (25): 15395–403. doi:10.1074/jbc.273.25.15395. ISSN 0021-9258. PMID 9624122.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Rahman, A; Kamal A; Roberts E A; Goldstein L S (September 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". J. Cell Biol. 146 (6): 1277–88. doi:10.1083/jcb.146.6.1277. ISSN 0021-9525. PMC 2156125. PMID 10491391.

KIF5A

Interactions

See also

References

Further reading