Lamin B2 is a protein that in humans is encoded by the LMNB2 gene. It is the second of two type B nuclear lamins, and it is associated with laminopathies.
Model organisms [ edit ]
Model organisms have been used in the study of Lamin B2 function. A conditional knockout mouse line, called Lmnb2 tm1a(KOMP)Wtsi [6 ] was generated as part of the [7 ] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. [8 ] [9 ] [10 ]
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion. [4 ] Twenty four tests were carried out on [11 ] mutant mice and four significant abnormalities were observed. No [4 ] homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice. Male heterozygotes displayed increased circulating creatinine levels and an increased susceptibility to infection. Salmonella [4 ]
See also [ edit ]
External links [ edit ]
References [ edit ]
^ "Clinical chemistry data for Lmnb2". Wellcome Trust Sanger Institute.
^ ". Wellcome Trust Sanger Institute. Salmonella infection data for Lmnb2"
^ ". Wellcome Trust Sanger Institute. Citrobacter infection data for Lmnb2"
^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi: 10.1111/j.1755-3768.2010.4142.x.
^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
^ "International Knockout Mouse Consortium".
^ "Mouse Genome Informatics".
^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi: 10.1038/nature10163. PMC 3572410. PMID 21677750.
^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi: 10.1038/474262a. PMID 21677718.
^ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018. PMID 17218247.
^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi: 10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.