Lamin B1

LMNB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KPW, 3JT0, 3TYY, 3UMN
Identifiers
Aliases	LMNB1, ADLD, LMN, LMN2, LMNB, lamin B1, MCPH26
External IDs	OMIM: 150340; MGI: 96795; HomoloGene: 55912; GeneCards: LMNB1; OMA:LMNB1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	126,837,020 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	56,886,496 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; monocyte; ; rectum; ; appendix; ; mucosa of transverse colon; ; bone marrow; ; blood; ; bone marrow cells; ; buccal mucosa cell;
	Top expressed in
	ventricular zone; ; granulocyte; ; tail of embryo; ; epiblast; ; abdominal wall; ; genital tubercle; ; thymus; ; yolk sac; ; ganglionic eminence; ; medial ganglionic eminence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase binding; structural molecule activity; protein binding; double-stranded DNA binding; sequence-specific double-stranded DNA binding;
Cellular component	nuclear matrix; nuclear inner membrane; nuclear membrane; membrane; intermediate filament; lamin filament; nucleoplasm; nucleus; nuclear envelope;
Biological process	interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4001
	16906
	ENSG00000113368
	ENSMUSG00000024590
	P20700
	P14733
	NM_001198557; NM_005573
	NM_010721
	NP_001185486; NP_005564
	NP_034851
	Wikidata
View/Edit Human	View/Edit Mouse

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

LMNB1 has been shown to interact with Thymopoietin.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113368 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024590 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lin F, Worman HJ (Nov 1995). "Structural organization of the human gene (LMNB1) encoding nuclear lamin B1". Genomics. 27 (2): 230–6. doi:10.1006/geno.1995.1036. PMID 7557986.
^ Wydner KL, McNeil JA, Lin F, Worman HJ, Lawrence JB (Feb 1997). "Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization". Genomics. 32 (3): 474–8. doi:10.1006/geno.1996.0146. PMID 8838815.
^ "Entrez Gene: LMNB1 lamin B1".
^ Furukawa, K; Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin". Eur. J. Biochem. 251 (3). GERMANY: 729–33. doi:10.1046/j.1432-1327.1998.2510729.x. ISSN 0014-2956. PMID 9490046. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Foisner, R; Gerace L (Jul 1993). "Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation". Cell. 73 (7). UNITED STATES: 1267–79. doi:10.1016/0092-8674(93)90355-T. ISSN 0092-8674. PMID 8324822. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)

Lamin B1

Interactions

See also

References

Further reading