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Intoxications with myristicin or nutmegessential oil slightly resemble the effects of MDMA, or MMDMA. Myristicin can, however, be converted into MMDA using a reaction similar to the one used to convert safrole into MDMA.[citation needed] Effects vary from person to person, but are often reported to be a state somewhere between waking and dreaming; euphoria is reported and nausea is often experienced, but some report that using cannabis can offset the nausea. Users also report bloodshot eyes and memory disturbances during nutmeg intoxication.[5]
In addition to a semi-conscious state, myristicin also has been known to induce psychoactive effects such as visual distortions. The dosage required to achieve such an effect varies from person to person and from source to source. The average dosage required to obtain these effects are somewhere in the region of .75 - 1.25g of ground fresh nutmeg for every 4.54kg (ten pounds) of body weight. This will vary with each nut and person.
Nutmeg intoxication has an extremely long time before peak is reached, sometimes taking up to 7 hours and effects can be felt for up to 24 hours with lingering effects lasting 72 hours. This could be considered unpleasant by some users because the negative effects such as nausea may linger for this period. [6][7]
Overdosage
Excessive usage of nutmeg has caused clinical intoxication, characterized by nausea, vomiting, dizziness, anxiety, headache, hallucinations and irrational behavior. Blood myristicin concentrations may be measured to confirm a diagnosis of poisoning. [8]
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Lee BK, Kim JH, Jung JW, Choi JW, Han ES, Lee SH, Ko KH, Ryu JH (2005). "Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells". Toxicol. Lett. 157 (1): 49–56. doi:10.1016/j.toxlet.2005.01.012. PMID15795093.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Truitt EB, Duritz G, Ebersberger EM (1963). "Evidence of monoamine oxidase inhibition by myristicin and nutmeg". Proc. Soc. Exp. Biol. Med. 112: 647–50. PMID13994372.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^McKenna A, Nordt SP, Ryan J (2004). "Acute nutmeg poisoning". European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine. 11 (4): 240–1. PMID15249817. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
