Spectrin, alpha 1

SPTA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OWA, 3LBX
Identifiers
Aliases	SPTA1, EL2, HPP, HS3, SPH3, SPTA, Spectrin, alpha 1, spectrin alpha, erythrocytic 1
External IDs	OMIM: 182860; MGI: 98385; HomoloGene: 74460; GeneCards: SPTA1; OMA:SPTA1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	158,686,715 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	174,076,016 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; bone marrow; ; bone marrow cells; ; testicle; ; gonad; ; monocyte; ; blood; ; right testis; ; left testis; ; spleen;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; blood; ; tibiofemoral joint; ; human fetus; ; right lobe of liver; ; body of femur; ; epithelium of lens; ; spleen; ; right ventricle; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; metal ion binding; actin filament binding; structural constituent of cytoskeleton; protein binding; actin binding; protein heterodimerization activity;
Cellular component	cytoplasm; cytosol; intrinsic component of the cytoplasmic side of the plasma membrane; cell cortex; actin cytoskeleton; cytoskeleton; spectrin; spectrin-associated cytoskeleton; cytoplasmic side of plasma membrane; membrane; axon; cortical cytoskeleton; cuticular plate;
Biological process	actin filament organization; MAPK cascade; axon guidance; endoplasmic reticulum to Golgi vesicle-mediated transport; actin filament capping; regulation of cell shape; lymphocyte homeostasis; porphyrin-containing compound biosynthetic process; plasma membrane organization; actin cytoskeleton organization; hemopoiesis; positive regulation of protein binding; positive regulation of T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	6708
	20739
	ENSG00000163554
	ENSMUSG00000026532
	P02549
	P08032
	NM_003126
	NM_011465
	NP_003117
	NP_035595
	Wikidata
View/Edit Human	View/Edit Mouse

Spectrin alpha chain, erythrocyte is a protein that in humans is encoded by the SPTA1 gene.^[5]

Template:PBB Summary

Interactions

Spectrin, alpha 1 has been shown to interact with Abl gene.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163554 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026532 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SPTA1 spectrin, alpha, erythrocytic 1 (elliptocytosis 2)".
^ Ziemnicka-Kotula, D; Xu J; Gu H; Potempska A; Kim K S; Jenkins E C; Trenkner E; Kotula L (May 1998). "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton". J. Biol. Chem. 273 (22). UNITED STATES: 13681–92. doi:10.1074/jbc.273.22.13681. ISSN 0021-9258. PMID 9593709. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading