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Protein-coding gene in the species Homo sapiens
Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene .[ 5] [ 6]
Function
Kinesins , such as KIF4A, are microtubule -based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.[ 6]
Interactions
KIF4A has been shown to interact with HMG20B [ 7] DNMT3B .[ 8]
Clinical significance
NTCP is the entry receptor for both Hepatitis B (HBV ) and Hepatitis D viruses (HDV ).[ 9] HBV and HDV infection through its regulation of the retrograde transport of NTCP from the cytoplasm to the cell surface where it acts as a receptor for HBV /HDV infection.[ 10]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000090889 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034311 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics . 88 (1–2): 41–42. doi :10.1159/000015482 . PMID 10773663 . S2CID 46074226 . ^ a b "Entrez Gene: KIF4A kinesin family member 4A" .^ Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35" . The Biochemical Journal . 374 (Pt 2): 497–503. doi :10.1042/BJ20030452 . PMC 1223617 PMID 12809554 . ^ Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery" . Nucleic Acids Research . 32 (9): 2716–2729. doi :10.1093/nar/gkh589 . PMC 419596 PMID 15148359 . ^ Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. (November 2012). Chen ZJ (ed.). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus" . eLife . 1 : e00049. doi :10.7554/eLife.00049 . PMC 3485615 PMID 23150796 . {{cite journal }}: CS1 maint: unflagged free DOI (link )^ Gad SA, Sugiyama M, Tsuge M, Wakae K, Fukano K, Oshima M, et al. (March 2022). "The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro" . PLOS Pathogens . 18 (3): e1009983. doi :10.1371/journal.ppat.1009983 . PMC 8970526 PMID 35312737 . {{cite journal }}: CS1 maint: unflagged free DOI (link )
Further reading
Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, Hirokawa N (October 1994). "A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally" . The Journal of Cell Biology . 127 (1): 187–201. doi :10.1083/jcb.127.1.187 . PMC 2120182 PMID 7929562 . Yan RT, Wang SZ (April 1997). "Increased chromokinesin immunoreactivity in retinoblastoma cells". Gene . 189 (2): 263–267. doi :10.1016/S0378-1119(96)00860-8 . PMID 9168136 . Tang Y, Winkler U, Freed EO, Torrey TA, Kim W, Li H, et al. (December 1999). "Cellular motor protein KIF-4 associates with retroviral Gag" . Journal of Virology . 73 (12): 10508–10513. doi :10.1128/JVI.73.12.10508-10513.1999 . PMC 113106 PMID 10559369 . Oh S, Hahn H, Torrey TA, Shin H, Choi W, Lee YM, et al. (September 2000). "Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1493 (1–2): 219–224. doi :10.1016/s0167-4781(00)00151-2 . PMID 10978527 . Lee YM, Lee S, Lee E, Shin H, Hahn H, Choi W, Kim W (December 2001). "Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis" . The Biochemical Journal . 360 (Pt 3): 549–556. doi :10.1042/0264-6021:3600549 . PMC 1222256 PMID 11736643 . Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35" . The Biochemical Journal . 374 (Pt 2): 497–503. doi :10.1042/BJ20030452 . PMC 1223617 PMID 12809554 . Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications . 308 (4): 793–801. doi :10.1016/S0006-291X(03)01486-4 . PMID 12927788 . Lee YM, Kim W (February 2004). "Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells" . Experimental & Molecular Medicine . 36 (1): 93–97. doi :10.1038/emm.2004.13 PMID 15031677 . Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery" . Nucleic Acids Research . 32 (9): 2716–2729. doi :10.1093/nar/gkh589 . PMC 419596 PMID 15148359 . Kurasawa Y, Earnshaw WC, Mochizuki Y, Dohmae N, Todokoro K (August 2004). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation" . The EMBO Journal . 23 (16): 3237–3248. doi :10.1038/sj.emboj.7600347 . PMC 514520 PMID 15297875 . Mazumdar M, Sundareshan S, Misteli T (August 2004). "Human chromokinesin KIF4A functions in chromosome condensation and segregation" . The Journal of Cell Biology . 166 (5): 613–620. doi :10.1083/jcb.200401142 . PMC 2172419 PMID 15326200 . Zhu C, Jiang W (January 2005). "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis" . Proceedings of the National Academy of Sciences of the United States of America . 102 (2): 343–348. Bibcode :2005PNAS..102..343Z . doi :10.1073/pnas.0408438102 PMC 544298 PMID 15625105 . Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle" . Proceedings of the National Academy of Sciences of the United States of America . 103 (14): 5391–5396. Bibcode :2006PNAS..103.5391N . doi :10.1073/pnas.0507066103 PMC 1459365 PMID 16565220 . Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology . 24 (10): 1285–1292. doi :10.1038/nbt1240 . PMID 16964243 . S2CID 14294292 .
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