Deschloroketamine

Deschloroketamine
Legal status
Legal status	CA: Schedule I; UK: Class B; Illegal in Latvia;
Identifiers
	IUPAC name 2-Phenyl-2-(methylamino)cyclohexanone;
CAS Number	4631-27-0;
PubChem CID	437168;
ChemSpider	386687;
CompTox Dashboard (EPA)	DTXSID10595730 ;
Chemical and physical data
Formula	C13H17NO
Molar mass	203.285 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNC1(CCCCC1=O)c2ccccc2;
	InChI InChI=1S/C13H17NO/c1-14-13(10-6-5-9-12(13)15)11-7-3-2-4-8-11/h2-4,7-8,14H,5-6,9-10H2,1H3; Key:ZAGBSZSITDFFAF-UHFFFAOYSA-N;

Deschloroketamine (DXE, DCK, 2'-Oxo-PCM) is a dissociative anesthetic^[1]^[2] that has been sold online as a designer drug.^[3]^[4]^[5]^[6] It has also been proposed for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation at doses of 2 mg per day.^[7]

Legal Status

Deschloroketamine is illegal in Latvia,^[8] and is covered by blanket bans in Canada and the UK.

References

^ Edward G. Robins; Yongjun Zhao; Imtiaz Khan; Anthony Wilson; Sajinder K. Luthra; Erik Årstad (March 2010). "Synthesis and in vitro evaluation of ¹⁸F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET". Bioorganic & Medicinal Chemistry Letters. 20 (5): 1749–1751. doi:10.1016/j.bmcl.2010.01.052. PMID 20138515.
^ Calvin L Stevens (31 May 1966). "Patent US 3254124 - Aminoketones and methods for their production". Retrieved 2 October 2015.
^ Giampietro Frison; Luca Zamengo; Flavio Zancanaro; Francesco Tisato; Pietro Traldi (January 2016). "Characterization of the designer drug deschloroketamine (2-methylamino-2-phenylcyclohexanone) by gas chromatography/mass spectrometry, liquid chromatography/high-resolution mass spectrometry, multistage mass spectrometry, and nuclear magnetic resonance". Rapid Communications in Mass Spectrometry. 30 (1): 151–160. doi:10.1002/rcm.7425. PMID 26661982.
^ "Alerta: descloroketamina vendida como ketamina en Barcelona" (in Spanish). Energy Control. Retrieved 2 October 2015.
^ Juanjo Villalba (27 March 2015). "Los efectos desconocidos de la sequía de ketamina" (in Spanish). Vice. Retrieved 2 October 2015.
^ Jeremy Knibbs (22 October 2015). "Party-drug testing shows its worth". The Medical Republic.
^ Detlef Preiss; Akos Tatar (23 May 1995). "Patent DE4409671 - Use of 2-methylamino-2-phenylcyclohexanone for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation". Retrieved 2 October 2015.
^ Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem

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[1] Edward G. Robins; Yongjun Zhao; Imtiaz Khan; Anthony Wilson; Sajinder K. Luthra; Erik Årstad (March 2010). "Synthesis and in vitro evaluation of ¹⁸F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET". Bioorganic & Medicinal Chemistry Letters. 20 (5): 1749–1751. doi:10.1016/j.bmcl.2010.01.052. PMID 20138515.

[2] Calvin L Stevens (31 May 1966). "Patent US 3254124 - Aminoketones and methods for their production". Retrieved 2 October 2015.

[3] Giampietro Frison; Luca Zamengo; Flavio Zancanaro; Francesco Tisato; Pietro Traldi (January 2016). "Characterization of the designer drug deschloroketamine (2-methylamino-2-phenylcyclohexanone) by gas chromatography/mass spectrometry, liquid chromatography/high-resolution mass spectrometry, multistage mass spectrometry, and nuclear magnetic resonance". Rapid Communications in Mass Spectrometry. 30 (1): 151–160. doi:10.1002/rcm.7425. PMID 26661982.

[4] "Alerta: descloroketamina vendida como ketamina en Barcelona" (in Spanish). Energy Control. Retrieved 2 October 2015.

[5] Juanjo Villalba (27 March 2015). "Los efectos desconocidos de la sequía de ketamina" (in Spanish). Vice. Retrieved 2 October 2015.

[6] Jeremy Knibbs (22 October 2015). "Party-drug testing shows its worth". The Medical Republic.

[7] Detlef Preiss; Akos Tatar (23 May 1995). "Patent DE4409671 - Use of 2-methylamino-2-phenylcyclohexanone for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation". Retrieved 2 October 2015.

[8] Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem

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