Alpha-actinin-4

ACTN4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WLX, 1YDI, 2R0O
Identifiers
Aliases	ACTN4, ACTININ-4, FSGS, FSGS1, Actinin alpha 4
External IDs	OMIM: 604638; MGI: 1890773; HomoloGene: 55857; GeneCards: ACTN4; OMA:ACTN4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	38,731,589 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,661,765 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; smooth muscle tissue; ; right coronary artery; ; stromal cell of endometrium; ; ascending aorta; ; placenta; ; body of uterus; ; islet of Langerhans; ; myometrium;
	Top expressed in
	corneal stroma; ; vestibular membrane of cochlear duct; ; tunica media of zone of aorta; ; pyloric antrum; ; lip; ; neural layer of retina; ; internal carotid artery; ; conjunctival fornix; ; external carotid artery; ; genital tubercle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; calcium ion binding; actin binding; protein-containing complex binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein homodimerization activity; protein N-terminus binding; nucleoside binding; transmembrane transporter binding; nuclear receptor coactivator activity; integrin binding; retinoic acid receptor binding; chromatin DNA binding; protein binding; actin filament binding; RNA binding; transcription coactivator activity;
Cellular component	extracellular exosome; extracellular region; brush border; pseudopodium; cytoplasm; actin cytoskeleton; cell junction; nucleus; stress fiber; cell-cell junction; neuron projection; focal adhesion; platelet alpha granule lumen; intracellular anatomical structure; Z discdkac; perinuclear region of cytoplasm; cortical cytoskeleton; extracellular space; cytosol; nuclear body; cytoskeleton; protein-containing complex; ribonucleoprotein complex;
Biological process	response to hypoxia; vesicle transport along actin filament; actin filament bundle assembly; positive regulation of NIK/NF-kappaB signaling; regulation of apoptotic process; positive regulation of cell migration; bicellular tight junction assembly; positive regulation of sodium:proton antiporter activity; protein localization to bicellular tight junction; platelet degranulation; positive regulation of pinocytosis; retinoic acid receptor signaling pathway; regulation of nucleic acid-templated transcription; protein transport; peroxisome proliferator activated receptor signaling pathway; negative regulation of substrate adhesion-dependent cell spreading; transport; tumor necrosis factor-mediated signaling pathway; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	81
	60595
	ENSG00000130402; ENSG00000282844
	ENSMUSG00000054808
	O43707
	P57780
	NM_004924; NM_001322033
	NM_021895; NM_001360548; NM_001360549; NM_001360550
	NP_001308962; NP_004915
	NP_068695; NP_001347477; NP_001347478; NP_001347479
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.^[5]

Template:PBB Summary

Interactions

Actinin alpha 4 has been shown to interact with PDLIM1,^[6]^[7] Sodium-hydrogen exchange regulatory cofactor 2,^[8] Collagen, type XVII, alpha 1,^[9] CAMK2A,^[10] CAMK2B,^[10] MAGI1^[11] and TRIM3.^[12]

References

^ ^a ^b ^c ENSG00000282844 GRCh38: Ensembl release 89: ENSG00000130402, ENSG00000282844 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054808 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ACTN4 actinin, alpha 4".
^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laysummary=, and |laydate= (help)
^ Vallenius, T; Luukko K; Mäkelä T P (Apr 2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4". J. Biol. Chem. 275 (15). UNITED STATES: 11100–5. doi:10.1074/jbc.275.15.11100. ISSN 0021-9258. PMID 10753915. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)
^ Kim, Jae Ho; Lee-Kwon Whaseon; Park Jong Bae; Ryu Sung Ho; Yun C H Chris; Donowitz Mark (Jun 2002). "Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis". J. Biol. Chem. 277 (26). United States: 23714–24. doi:10.1074/jbc.M200835200. ISSN 0021-9258. PMID 11948184. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Gonzalez, A M; Otey C; Edlund M; Jones J C (Dec 2001). "Interactions of a hemidesmosome component and actinin family members". J. Cell Sci. 114 (Pt 23). England: 4197–206. ISSN 0021-9533. PMID 11739652. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)
^ ^a ^b Walikonis, R S; Oguni A; Khorosheva E M; Jeng C J; Asuncion F J; Kennedy M B (Jan 2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. 21 (2). United States: 423–33. PMID 11160423. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Patrie, Kevin M; Drescher Andrew J; Welihinda Ajith; Mundel Peter; Margolis Ben (Aug 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". J. Biol. Chem. 277 (33). United States: 30183–90. doi:10.1074/jbc.M203072200. ISSN 0021-9258. PMID 12042308. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ El-Husseini, A E; Kwasnicka D; Yamada T; Hirohashi S; Vincent S R (Jan 2000). "BERP, a novel ring finger protein, binds to alpha-actinin-4". Biochem. Biophys. Res. Commun. 267 (3). UNITED STATES: 906–11. doi:10.1006/bbrc.1999.2045. ISSN 0006-291X. PMID 10673389. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

External links

Human ACTN4 genome location and ACTN4 gene details page in the UCSC Genome Browser.

Template:PBB Controls

[refGRCh38Ensembl-1] ENSG00000282844 GRCh38: Ensembl release 89: ENSG00000130402, ENSG00000282844 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054808 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ACTN4 actinin, alpha 4".

[pmid16189514-6] Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laysummary=, and |laydate= (help)

[pmid10753915-7] Vallenius, T; Luukko K; Mäkelä T P (Apr 2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4". J. Biol. Chem. 275 (15). UNITED STATES: 11100–5. doi:10.1074/jbc.275.15.11100. ISSN 0021-9258. PMID 10753915. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

[pmid11948184-8] Kim, Jae Ho; Lee-Kwon Whaseon; Park Jong Bae; Ryu Sung Ho; Yun C H Chris; Donowitz Mark (Jun 2002). "Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis". J. Biol. Chem. 277 (26). United States: 23714–24. doi:10.1074/jbc.M200835200. ISSN 0021-9258. PMID 11948184. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

[pmid11739652-9] Gonzalez, A M; Otey C; Edlund M; Jones J C (Dec 2001). "Interactions of a hemidesmosome component and actinin family members". J. Cell Sci. 114 (Pt 23). England: 4197–206. ISSN 0021-9533. PMID 11739652. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

[pmid11160423-10] Walikonis, R S; Oguni A; Khorosheva E M; Jeng C J; Asuncion F J; Kennedy M B (Jan 2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. 21 (2). United States: 423–33. PMID 11160423. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid12042308-11] Patrie, Kevin M; Drescher Andrew J; Welihinda Ajith; Mundel Peter; Margolis Ben (Aug 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". J. Biol. Chem. 277 (33). United States: 30183–90. doi:10.1074/jbc.M203072200. ISSN 0021-9258. PMID 12042308. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

[pmid10673389-12] El-Husseini, A E; Kwasnicka D; Yamada T; Hirohashi S; Vincent S R (Jan 2000). "BERP, a novel ring finger protein, binds to alpha-actinin-4". Biochem. Biophys. Res. Commun. 267 (3). UNITED STATES: 906–11. doi:10.1006/bbrc.1999.2045. ISSN 0006-291X. PMID 10673389. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

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Alpha-actinin-4

Interactions

See also

References

Further reading

External links