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Anticholinergic deliriant drug
EA-3167
1-Azabicyclo[2.2.2]octan-8-yl 2-cyclopentyl-2-hydroxy-2-phenylethanoate
CAS Number PubChem CID ChemSpider ChEMBL CompTox Dashboard (EPA ) Formula C 20 H 29 N O 3 Molar mass 331.456 g·mol−1 3D model (JSmol )
C1CCC(C1)C(C2=CC=CC=C2)(C(=O)OC3CN4CCC3CC4)O
InChI=1S/C20H27NO3/c22-19(24-18-14-21-12-10-15(18)11-13-21)20(23,17-8-4-5-9-17)16-6-2-1-3-7-16/h1-3,6-7,15,17-18,23H,4-5,8-14H2
Key:RFXCNPOWSCFJCD-UHFFFAOYSA-N
(verify)
EA-3167 is a potent and long-lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program , in an attempt to develop non-lethal incapacitating agents . EA-3167 has identical effects to QNB, but is even more potent and longer-lasting, with an effective dose when administered by injection of as little as 2.5 μg/kg (i.e. 0.2 milligrams for an 80 kg person), and a duration of 120–240 hours (5–10 days).[ 1] [ 2] However unlike QNB, EA-3167 was never weaponized or manufactured in bulk.
Stereoisomers of EA-3167 have also been synthesized under the codename HL-031120.[ 3]
See also
References
^ Wills H (1982). "Appendix I: Digest Report -- Anticholinergic Chemicals" . In National Research Council (U.S.). Committee on Toxicology (ed.). Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents . Vol. 1. Washington, D.C.: National Academies Press. pp. 195–196. OCLC 35472774 .
^ Ketchum JS (2006). Chemical Warfare Secrets Almost Forgotten. A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War . ChemBooks. ISBN 978-1-4243-0080-8 .
^ Liu YM, Liu H, Zhong BH, Liu KL (2006). "Stereoselective Synthesis of the Optical Isomers of a New Muscarinic Receptor Antagonist, HL‐031120". Synthetic Communications . 36 (13): 1815–1822. doi :10.1080/00397910600602453 . S2CID 96011273 .
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