- Not to be confused with alphacetylmethadol (α-acetylmethadol) or levacetylmethadol (L-α-acetylmethadol).
|Systematic (IUPAC) name|
|Legal status||Controlled (S8) (AU) Schedule I (US)|
|Mol. mass||353.498 g/mol|
Acetylmethadol (INN), also known as methadyl acetate (USAN), is a synthetic opioid analgesic. It is a racemic mixture of alphacetylmethadol (α-acetylmethadol) and betacetylmethadol (β-acetylmethadol), which are in turn racemic mixtures of levacetylmethadol (LAAM; L-α-acetylmethadol) and D-α-acetylmethadol and L-β-acetylmethadol and D-β-acetylmethadol, respectively. Hence, acetylmethadol has four possible optical isomers. All of these isomers have been shown to partially or fully substitute for the discriminative stimulus effects of heroin in rats, and thus it can be inferred that, in addition to LAAM which is used clinically as such, they are all likely to be active opioid analgesics in humans.
- Richard Lawrence Miller (30 December 2002). The Encyclopedia of Addictive Drugs. Greenwood Publishing Group. p. 222. ISBN 978-0-313-31807-8. Retrieved 15 May 2012.
- Newman JL, Vann RE, May EL, Beardsley PM (October 2002). "Heroin discriminative stimulus effects of methadone, LAAM and other isomers of acetylmethadol in rats". Psychopharmacology 164 (1): 108–14. doi:10.1007/s00213-002-1198-8. PMID 12373424.
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